定向磁性骨水泥在低于临床安全温度下对兔骨肿瘤的抑制作用
Bone tumor suppression in rabbits by hyperthermia below the clinical safety limit using aligned magnetic bone cement
摘要：
在临床安全的磁场参数下，在生理环境中证明纳米颗粒的高效交流（AC）磁场加热仍然是一个巨大的挑战，阻碍了磁热疗的临床应用。在这项工作中，我们报告了异常高的损耗功率的磁性骨水泥的临床安全极限下的交流场参数，将直流场取向的软磁Zn0.3Fe2.7O4纳米粒子与低浓度。在430 kHz、4kA/m的AC场下，具有0.2wt%纳米颗粒的定向骨水泥在180秒内实现了30 ℃的温度升高。这相当于比损耗功率值为327 W/g金属，固有损耗功率为47 nHm^2/kg，与随机取向的样品相比提高了50倍。高性能磁性骨水泥可有效抑制肿瘤在血液循环快速降温的新西兰白兔骨髓腔内的生长，并显著提高存活率。
英文摘要：
Demonstrating highly efficient alternating current (AC) magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters has remained a great challenge, hindering clinical applications of magnetic hyperthermia. In this work, we report exceptionally high loss power of magnetic bone cement under clinical safety limit of AC field parameters, incorporating DC field-aligned soft magnetic Zn0.3Fe2.7O4 nanoparticles with low concentration. Under an AC field of 4 kA/m at 430 kHz, the aligned bone cement with 0.2 wt% nanoparticles achieved a temperature increase of 30 C in 180 s. This amounts to a specific loss power value of 327 W/gmetal and an intrinsic loss power of 47 nHm^2/kg, which is enhanced by 50-fold compared to randomly oriented samples. The high-performance magnetic bone cement allows for the demonstration of effective hyperthermia suppression of tumor growth in the bone marrow cavity of New Zealand White Rabbits subjecting to rapid cooling due to blood circulation, and significant enhancement of survival rate.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
