基于并联谐振器的无线无电池生物传感器
A Wireless and Battery-free Biosensor Based on Parallel Resonators for Monitoring a Wide Range of Biosignals
摘要：
本文提出了一种新型的无线，无电池，无标签的生物传感器微创和非侵入性介电常数传感的应用，如检测葡萄糖水平的间质真皮液。小型化，完全无源传感器是基于两个对称的平行0.8毫米$^3$ LC（电感电容）谐振器。每个电感器在其端子之一处与导电板集成。无源传感器的主磁场在谐振器外部占主导地位，在传感器外部产生有效电容，这与之前的研究报告不同，在之前的研究中，有效电容仅限于谐振器线之间。在两种不同的情况下进一步分析所提出的传感器，以改变有效电容的区域，并测试其对压力监测的适用性，例如伤口监测;首先，通过重新定位两个谐振器中的一个，其次，通过用导电板替换谐振器中的一个。实验结果证实了所提出的无源传感器在检测水溶液中的葡萄糖浓度方面的性能，对于微创和无创监测，在0-500 mg/dL的葡萄糖范围内，灵敏度分别为500和46 kHz/（mg/dL），体积样品要求低至60 $μ$ L。此外，通过重新定位谐振器中的一个，有效电容位于无源传感器内部，使其适合于伤口监测。结果表明，考虑到分离是感测伤口的压力或愈合的主要因素，在0.2-0.5 mm的分离范围内，可以使谐振偏移相对于谐振器之间的分离的变化相当线性，灵敏度为2.5 $\times 10^3$ MHz/mm。
英文摘要：
This paper proposes a novel wireless, battery-free, and label-free biosensor for minimally invasive and non-invasive permittivity sensing for applications such as detecting glucose levels in the interstitial dermal fluid. The miniaturized, fully passive sensor is based on two symmetric parallel 0.8 mm$^3$ LC (inductor-capacitor) resonators. Each inductor is integrated with a conductive plate at one of its terminals. The passive sensor's main field is dominant outside the resonators, creating an effective capacitance outside the sensor, unlike reported in previous studies where the effective capacitance was limited to between the resonator lines. The proposed sensor was further analyzed under two different scenarios to change the region of effective capacitance and test its suitability for pressure monitoring, such as wound monitoring; first, by repositioning one of the two resonators, and second, by replacing one of the resonators with a conductive plate. The experimental results confirmed the proposed passive sensor's performance in detecting the glucose concentration in an aqueous solution with a sensitivity of 500 and 46 kHz/(mg/dL) for minimal invasive and non-invasive monitoring, respectively, within the glucose range of 0-500 mg/dL with volume sample requirements as low as 60 $μ$L. Further, by repositioning one of the resonators, the effective capacitance lies inside the passive sensor, making it suitable for wound monitoring. The results indicated that the resonance shift can be made fairly linear with respect to the variation in the separation between the resonators with a sensitivity of 2.5$\times 10^3$ MHz/mm within the separation range of 0.2-0.5 mm, considering separation as the main factor to sense the pressure or healing of the wound.
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