Deep learning-based segmentation of the liver and hepatic lesions therein steadily gains relevance in clinical practice due to the increasing incidence of liver cancer each year. Whereas various network variants with overall promising results in the field of medical image segmentation have been successfully developed over the last years, almost all of them struggle with the challenge of accurately segmenting hepatic lesions in magnetic resonance imaging (MRI). This led to the idea of combining elements of convolutional and transformer-based architectures to overcome the existing limitations. This work presents a hybrid network called SWTR-Unet, consisting of a pretrained ResNet, transformer blocks as well as a common Unet-style decoder path. This network was primarily applied to single-modality non-contrast-enhanced liver MRI and additionally to the publicly available computed tomography (CT) data of the liver tumor segmentation (LiTS) challenge to verify the applicability on other modalities. For a broader evaluation, multiple state-of-the-art networks were implemented and applied, ensuring a direct comparability. Furthermore, correlation analysis and an ablation study were carried out, to investigate various influencing factors on the segmentation accuracy of the presented method. With Dice scores of averaged 98+-2% for liver and 81+-28% lesion segmentation on the MRI dataset and 97+-2% and 79+-25%, respectively on the CT dataset, the proposed SWTR-Unet proved to be a precise approach for liver and hepatic lesion segmentation with state-of-the-art results for MRI and competing accuracy in CT imaging. The achieved segmentation accuracy was found to be on par with manually performed expert segmentations as indicated by inter-observer variabilities for liver lesion segmentation. In conclusion, the presented method could save valuable time and resources in clinical practice.
The Second Hospital of Shandong University, Shandong University（山东大学第二医院，山东大学）；Shenzhen Third People’s Hospital, the Second Affiliated Hospital of Southern University of Science and Technology（深圳市第三人民医院，南方科技大学第二附属医院）；The First Affiliated Hospital of Hainan Medical University（海南医科大学第一附属医院）；Wuhan Asia General Hospital（武汉亚洲总医院）；Shanxi Medical University（山西医科大学）；Chengdu First People’s Hospital（成都市第一人民医院）；Keck School of Medicine, University of Southern California（南加州大学凯克医学院）；Shandong Provincial Hospital Affiliated to Shandong First Medical University（山东第一医科大学附属山东省立医院）
Despite high global prevalence of hepatic steatosis, no automated diagnostics demonstrated generalizability in detecting steatosis on multiple international datasets. Traditionally, hepatic steatosis detection relies on clinicians selecting the region of interest (ROI) on computed tomography (CT) to measure liver attenuation. ROI selection demands time and expertise, and therefore is not routinely performed in populations. To automate the process, we validated an existing artificial intelligence (AI) system for 3D liver segmentation and used it to purpose a novel method: AI-ROI, which could au…
Image Sciences Institute, University Medical Center Utrecht（乌得勒支大学医学中心图像科学研究所）；Department of Biomedical Engineering, Eindhoven University of Technology（埃因霍温理工大学生物医学工程系）
Despite the successes of deep learning techniques at detecting objects in medical images, false positive detections occur which may hinder an accurate diagnosis. We propose a technique to reduce false positive detections made by a neural network using an SVM classifier trained with features derived from the uncertainty map of the neural network prediction. We demonstrate the effectiveness of this method for the detection of liver lesions on a dataset of abdominal MR images. We find that the use of a dropout rate of 0.5 produces the least number of false positives in the neural network predicti…
Technical University of Munich（慕尼黑工业大学）；University of California, Irvine（加利福尼亚大学尔湾分校）
The segmentation of liver lesions is crucial for detection, diagnosis and monitoring progression of liver cancer. However, design of accurate automated methods remains challenging due to high noise in CT scans, low contrast between liver and lesions, as well as large lesion variability. We propose a 3D automatic, unsupervised method for liver lesions segmentation using a phase separation approach. It is assumed that liver is a mixture of two phases: healthy liver and lesions, represented by different image intensities polluted by noise. The Cahn-Hilliard equation is used to remove the noise an…
Transfer learning and joint learning approaches are extensively used to improve the performance of Convolutional Neural Networks (CNNs). In medical imaging applications in which the target dataset is typically very small, transfer learning improves feature learning while joint learning has shown effectiveness in improving the network's generalization and robustness. In this work, we study the combination of these two approaches for the problem of liver lesion segmentation and classification. For this purpose, 332 abdominal CT slices containing lesion segmentation and classification of three le…
SIAT, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；The Chinese University of Hong Kong（香港中文大学）
Purpose: Segmentation of liver vessels from CT images is indispensable prior to surgical planning and aroused broad range of interests in the medical image analysis community. Due to the complex structure and low contrast background, automatic liver vessel segmentation remains particularly challenging. Most of the related researches adopt FCN, U-net, and V-net variants as a backbone. However, these methods mainly focus on capturing multi-scale local features which may produce misclassified voxels due to the convolutional operator's limited locality reception field. Methods: We propose a robust…
Colorectal liver metastasis is one of most aggressive liver malignancies. While the definition of lesion type based on CT images determines the diagnosis and therapeutic strategy, the discrimination between cancerous and non-cancerous lesions are critical and requires highly skilled expertise, experience and time. In the present work we introduce an end-to-end deep learning approach to assist in the discrimination between liver metastases from colorectal cancer and benign cysts in abdominal CT images of the liver. Our approach incorporates the efficient feature extraction of InceptionV3 combin…
PLUS: Plug-and-Play Enhanced Liver Lesion Diagnosis Model on Non-Contrast CT Scans
School of Biomedical Engineering, Tsinghua University（清华大学生物医学工程学院）；DAMO Academy, Alibaba Group（阿里集团达摩院）；Hupan Lab（汇看实验室）；Department of Radiology, Shengjing Hospital of China Medical University（中国医科大学附属盛京医院放射科）；Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Zhejiang University（浙江大学医学院附属第一医院肝胆外科）
SDR-Former: A Siamese Dual-Resolution Transformer for Liver Lesion Classification Using 3D Multi-Phase Imaging
Deepwise Healthcare（深睿医疗）；Sir Run Run Shaw Hospital, Zhejiang University School of Medicine（浙江大学医学院附属邵逸夫医院）；Ningbo Medical Center Lihuili Hospital（宁波医疗中心李惠利医院）；The University of Hong Kong（香港大学）
Technical University of Munich（慕尼黑工业大学）；LMU Hospital Grosshadern（路德维希-马克西米利安-慕尼黑大学格罗斯哈德恩医院）
Automatic segmentation of the liver and hepatic lesions is an important step towards deriving quantitative biomarkers for accurate clinical diagnosis and computer-aided decision support systems. This paper presents a method to automatically segment liver and lesions in CT and MRI abdomen images using cascaded fully convolutional neural networks (CFCNs) enabling the segmentation of a large-scale medical trial or quantitative image analysis. We train and cascade two FCNs for a combined segmentation of the liver and its lesions. In the first step, we train a FCN to segment the liver as ROI input …
Sun Yat-sen University（中山大学）；The First Affiliated Hospital, Sun Yat-sen University（中山大学附属第一医院）；Infervision Inc.（推想医疗科技股份有限公司）
Hepatocellular carcinoma (HCC) is the second most frequent cause of malignancy-related death and is one of the diseases with the highest incidence in the world. Because the liver is the only organ in the human body that is supplied by two major vessels: the hepatic artery and the portal vein, various types of malignant tumors can spread from other organs to the liver. And due to the liver masses' heterogeneous and diffusive shape, the tumor lesions are very difficult to be recognized, thus automatic lesion detection is necessary for the doctors with huge workloads. To assist doctors, this work…
Eastern Hepatobiliary Surgery Hospital（东方肝胆外科医院）；Ping An Technology（平安科技）；Georgia Institute of Technology（佐治亚理工学院）；PAII Inc.（PAII公司）
Objectives: to propose a fully-automatic computer-aided diagnosis (CAD) solution for liver lesion characterization, with uncertainty estimation. Methods: we enrolled 400 patients who had either liver resection or a biopsy and was diagnosed with either hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, or secondary metastasis, from 2006 to 2019. Each patient was scanned with T1WI, T2WI, T1WI venous phase (T2WI-V), T1WI arterial phase (T1WI-A), and DWI MRI sequences. We propose a fully-automatic deep CAD pipeline that localizes lesions from 3D MRI studies using key-slice parsing an…
Multi-target and multi-stage liver lesion segmentation and detection in multi-phase computed tomography scans
King Fahd University of Petroleum and Minerals（法赫德国王石油矿产大学）；Vinbrain JSC（Vinbrain股份公司）；Le Quy Don Technical University（黎贵敦技术大学）；University Medical Center at Ho Chi Minh City（胡志明市大学医疗中心）
Barcelona Supercomputing Center (BSC)（巴塞罗那超级计算中心）；Eidgenössische Technische Hochschule Zürich (ETH Zürich)（苏黎世联邦理工学院）；Universitat Politècnica de Catalunya (UPC)（加泰罗尼亚理工大学）
A fully automatic technique for segmenting the liver and localizing its unhealthy tissues is a convenient tool in order to diagnose hepatic diseases and assess the response to the according treatments. In this work we propose a method to segment the liver and its lesions from Computed Tomography (CT) scans using Convolutional Neural Networks (CNNs), that have proven good results in a variety of computer vision tasks, including medical imaging. The network that segments the lesions consists of a cascaded architecture, which first focuses on the region of the liver in order to segment the lesion…
Tel Aviv University（特拉维夫大学）；The Chaim Sheba Medical Center（夏姆谢巴医疗中心）；Bar-Ilan University（巴伊兰大学）
Deep learning methods, and in particular convolutional neural networks (CNNs), have led to an enormous breakthrough in a wide range of computer vision tasks, primarily by using large-scale annotated datasets. However, obtaining such datasets in the medical domain remains a challenge. In this paper, we present methods for generating synthetic medical images using recently presented deep learning Generative Adversarial Networks (GANs). Furthermore, we show that generated medical images can be used for synthetic data augmentation, and improve the performance of CNN for medical image classificatio…
AMPLIFAI: A Multiphase CT Dataset for Benchmarking Clinical Reasoning in LI-RADS Assessment of Liver Lesions
University of Maryland, College Park（马里兰大学帕克分校）；University of Maryland School of Medicine（马里兰大学医学院）；University of Maryland Institute for Health Computing（马里兰大学健康计算研究所）；University of Maryland Medical System（马里兰大学医学系统）
Surgical resections are the most prevalent curative treatment for primary liver cancer. Tumors located in critical positions are known to complexify liver resections (LR). While experienced surgeons in specialized medical centers may have the necessary expertise to accurately anticipate LR complexity, and prepare accordingly, an objective method able to reproduce this behavior would have the potential to improve the standard routine of care, and avoid intra- and postoperative complications. In this article, we propose CoRe, an automated medical image processing pipeline for the prediction of p…
Stanford University（斯坦福大学）；University of California, San Diego Medical Center（加州大学圣地亚哥医学中心）
We propose a novel method, the adaptive local window, for improving level set segmentation technique. The window is estimated separately for each contour point, over iterations of the segmentation process, and for each individual object. Our method considers the object scale, the spatial texture, and changes of the energy functional over iterations. Global and local statistics are considered by calculating several gray level co-occurrence matrices. We demonstrate the capabilities of the method in the domain of medical imaging for segmenting 233 images with liver lesions. To illustrate the stre…
PAII Inc.（PAII公司）；The University of Texas at Arlington（德克萨斯大学阿灵顿分校）；Chang Gung Memorial Hospital（长庚纪念医院）；PingAn Technology（平安科技）
In medical imaging, organ/pathology segmentation models trained on current publicly available and fully-annotated datasets usually do not well-represent the heterogeneous modalities, phases, pathologies, and clinical scenarios encountered in real environments. On the other hand, there are tremendous amounts of unlabelled patient imaging scans stored by many modern clinical centers. In this work, we present a novel segmentation strategy, co-heterogenous and adaptive segmentation (CHASe), which only requires a small labeled cohort of single phase imaging data to adapt to any unlabeled cohort of …
Automated surgical planning with nnU-Net: delineation of the anatomy in hepatobiliary phase MRI
The Netherlands Cancer Institute – Antoni van Leeuwenhoek（荷兰癌症研究所 – 安东尼·范·列文虎克）；National Center for Tumor Diseases (NCT), NCT/UCC Dresden（国家肿瘤疾病中心（NCT），NCT/UCC 德累斯顿）；DKFZ（德国癌症研究中心）；Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology（德累斯顿工业大学医学院及卡尔·古斯塔夫·卡鲁斯大学医院）；The Centre for Tactile Internet with Human-in-the-Loop (CeTI), TUD Dresden University of Technology（德累斯顿工业大学触觉互联网与人机协同中心）；University of Twente（特文特大学）
Automatic liver segmentation in 3D medical images is essential in many clinical applications, such as pathological diagnosis of hepatic diseases, surgical planning, and postoperative assessment. However, it is still a very challenging task due to the complex background, fuzzy boundary, and various appearance of liver. In this paper, we propose an automatic and efficient algorithm to segment liver from 3D CT volumes. A deep image-to-image network (DI2IN) is first deployed to generate the liver segmentation, employing a convolutional encoder-decoder architecture combined with multi-level feature…
Qatar University（卡塔尔大学）；Hamad Medical Corporation（哈马德医疗公司）
Machine learning and computer vision techniques have grown rapidly in recent years due to their automation, suitability, and ability to generate astounding results. Hence, in this paper, we survey the key studies that are published between 2014 and 2022, showcasing the different machine learning algorithms researchers have used to segment the liver, hepatic tumors, and hepatic-vasculature structures. We divide the surveyed studies based on the tissue of interest (hepatic-parenchyma, hepatic-tumors, or hepatic-vessels), highlighting the studies that tackle more than one task simultaneously. Add…
Multi-modal Liver Segmentation and Fibrosis Staging Using Real-world MRI Images
Multiscale X-ray Imaging (MXI) Lab, Department of Mechanical Engineering, University College London（多尺度X射线成像实验室，机械工程系，伦敦大学学院）；Centre for Clinical Brain Sciences, University of Edinburgh（临床脑科学中心，爱丁堡大学）；MRC Weatherall Institute of Molecular Medicine, University of Oxford（MRC韦伯尔分子医学研究所，牛津大学）
James Cook University（詹姆斯·库克大学）；Mahidol University（玛希隆大学）；University of Bremen（不来梅大学）
Automatic segmentation of hepatic lesions in computed tomography (CT) images is a challenging task to perform due to heterogeneous, diffusive shape of tumors and complex background. To address the problem more and more researchers rely on assistance of deep convolutional neural networks (CNN) with 2D or 3D type architecture that have proven to be effective in a wide range of computer vision tasks, including medical image processing. In this technical report, we carry out research focused on more careful approach to the process of learning rather than on complex architecture of the CNN. We have…
BioFact-MoE: Biologically Factorized Mixture of Experts for Vision-Language Prognostic Modeling in Hepatocellular Carcinoma
Department of Radiology \& Biomedical Imaging, Department of Biomedical Engineering, Department of Electrical Engineering, Department of Statistics \& Data Science Yale University, New Haven, CT, 06510, USA
Benchmarking Deep Learning for Future Liver Remnant Segmentation in Colorectal Liver Metastasis
University of California, Irvine Donald Bren School of Information and Computer Science（加州大学尔湾分校唐纳德·布伦信息与计算机科学学院）；University of California, Irvine School of Medicine（加州大学尔湾分校医学院）
School of Computer Science and Communication Engineering, Jiangsu University（江苏大学计算机科学与通信工程学院）；Department of Imaging, Affiliated Hospital of Jiangsu University（江苏大学附属医院影像科）；Department of Information, Affiliated Hospital of Jiangsu University（江苏大学附属医院信息科）；Medical College of Jiangsu University（江苏大学医学院）
Center for Image Sciences, University Medical Center Utrecht, the Netherlands（荷兰乌得勒支大学医学中心影像科学中心）；Department of Radiology, University Medical Center Utrecht, the Netherlands（荷兰乌得勒支大学医学中心放射科）
Motion correction of dynamic contrast enhanced magnetic resonance images (DCE-MRI) is a challenging task, due to changes in image appearance. In this study a groupwise registration, using a principle component analysis (PCA) based metric,1 is evaluated for clinical DCE MRI of the liver. The groupwise registration transforms the images to a common space, rather than to a reference volume as conventional pairwise methods do, and computes the similarity metric on all volumes simultaneously. This groupwise registration method is compared to a pairwise approach using a mutual information metric. Cl…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Ping An Insurance Company of China（中国平安保险公司）
Developing an effective liver and liver tumor segmentation model from CT scans is very important for the success of liver cancer diagnosis, surgical planning and cancer treatment. In this work, we propose a two-stage framework for 2D liver and tumor segmentation. The first stage is a coarse liver segmentation network, while the second stage is an edge enhanced network (E$^2$Net) for more accurate liver and tumor segmentation. E$^2$Net explicitly models complementary objects (liver and tumor) and their edge information within the network to preserve the organ and lesion boundaries. We introduce…
The ULS23 Challenge: a Baseline Model and Benchmark Dataset for 3D Universal Lesion Segmentation in Computed Tomography
Radboud University Medical Center（拉德堡德大学医学中心）；Jeroen Bosch Hospital（杰伦博世医院）；University Medical Center Groningen（格罗宁根大学医学中心）；Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学梅维斯研究所）
MRI2Rep: Autoregressive Structured Report Generation for 3D Liver MRI
Department of Biomedical Engineering（生物医学工程系）；Department of Radiology & Biomedical Imaging（放射学与生物医学影像系）；Department of Electrical Engineering（电气工程系）；Yale University（耶鲁大学）；Johns Hopkins University（约翰霍普金斯大学）；Johns Hopkins Medicine（约翰霍普金斯医学）
Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；University of California, Los Angeles（加利福尼亚大学洛杉矶分校）；University of Southern California（南加利福尼亚大学）；Lenovo Research（联想研究院）；Lenovo Ltd.（联想有限公司）
Purpose: Automated liver tumor segmentation from Computed Tomography (CT) images is a necessary prerequisite in the interventions of hepatic abnormalities and surgery planning. However, accurate liver tumor segmentation remains challenging due to the large variability of tumor sizes and inhomogeneous texture. Recent advances based on Fully Convolutional Network (FCN) for medical image segmentation drew on the success of learning discriminative pyramid features. In this paper, we propose a Decoupled Pyramid Correlation Network (DPC-Net) that exploits attention mechanisms to fully leverage both …
Automatic liver lesion segmentation is a challenging task while having a significant impact on assisting medical professionals in the designing of effective treatment and planning proper care. In this paper we propose a cascaded system that combines both 2D and 3D convolutional neural networks to effectively segment hepatic lesions. Our 2D network operates on a slice by slice basis to segment the liver and larger tumors, while we use a 3D network to detect small lesions that are often missed in a 2D segmentation design. We employ this algorithm on the LiTS challenge obtaining a Dice score per …
PAII Inc.（PAII 公司）；Chang Gung Memorial Hospital, Linkou Medical Center（长庚纪念医院林口医学中心）；Institute of Molecular and Genomic Medicine, National Health Research Institutes（国家卫生研究院分子与基因组医学研究所）；Ping An Insurance Group（平安保险集团）
Background & Aims: Hepatic steatosis is a major cause of chronic liver disease. 2D ultrasound is the most widely used non-invasive tool for screening and monitoring, but associated diagnoses are highly subjective. We developed a scalable deep learning (DL) algorithm for quantitative scoring of liver steatosis from 2D ultrasound images. Approach & Results: Using retrospectively collected multi-view ultrasound data from 3,310 patients, 19,513 studies, and 228,075 images, we trained a DL algorithm to diagnose steatosis stages (healthy, mild, moderate, or severe) from ultrasound diagnoses. Perform…
EAGLE: An Efficient Global Attention Lesion Segmentation Model for Hepatic Echinococcosis
School of Computer Technology and Application, Qinghai University（青海大学计算机技术与应用学院）；Department of Computer Science and Technology, Tsinghua University（清华大学计算机科学与技术系）；Intelligent Computing and Application Laboratory of Qinghai Province, Qinghai University（青海省智能计算与应用实验室）；School of Chemical Engineering, Qinghai University（青海大学化学工程学院）；Department of General Surgery, Affiliated Hospital of Qinghai University（青海大学附属医院普外科）；Department of Medical Engineering Integration and Translational Application, Affiliated Hospital of Qinghai University（青海大学附属医院医学工程整合与转化应用系）
Language-guided Scale-aware MedSegmentor for Lesion Segmentation in Medical Imaging
College of Computer Science and Technology, Zhejiang University（浙江大学计算机科学与技术学院）；Department of Radiology, Sir Run Run Shaw Hospital（邵逸夫医院放射科）；College of Information Science and Engineering, Ritsumeikan University（立命馆大学信息科学与工程学院）
Heidelberg University（海德堡大学）；University Medical Center Mannheim（曼海姆大学医学中心）
At present, lesion segmentation is still performed manually (or semi-automatically) by medical experts. To facilitate this process, we contribute a fully-automatic lesion segmentation pipeline. This work proposes a method as a part of the LiTS (Liver Tumor Segmentation Challenge) competition for ISBI 17 and MICCAI 17 comparing methods for automatics egmentation of liver lesions in CT scans. By utilizing cascaded, densely connected 2D U-Nets and a Tversky-coefficient based loss function, our framework achieves very good shape extractions with high detection sensitivity, with competitive scores …
Medical Faculty Mannheim（曼海姆医学院）；Heidelberg University（海德堡大学）；Tooploox
We propose a novel procedure to improve liver and lesion segmentation from CT scans for U-Net based models. Our method extends standard segmentation pipelines to focus on higher target recall or reduction of noisy false-positive predictions, boosting overall segmentation performance. To achieve this, we include segmentation errors into a new learning process appended to the main training setup, allowing the model to find features which explain away previous errors. We evaluate this on semantically distinct architectures: cascaded two- and three-dimensional as well as combined learning setups f…
The success of supervised lesion segmentation algorithms using Computed Tomography (CT) exams depends significantly on the quantity and variability of samples available for training. While annotating such data constitutes a challenge itself, the variability of lesions in the dataset also depends on the prevalence of different types of lesions. This phenomenon adds an inherent bias to lesion segmentation algorithms that can be diminished, among different possibilities, using aggressive data augmentation methods. In this paper, we present a method for implanting realistic lesions in CT slices to…
Accurate liver and lesion segmentation from computed tomography (CT) images are highly demanded in clinical practice for assisting the diagnosis and assessment of hepatic tumor disease. However, automatic liver and lesion segmentation from contrast-enhanced CT volumes is extremely challenging due to the diversity in contrast, resolution, and quality of images. Previous methods based on UNet for 2D slice-by-slice or 3D volume-by-volume segmentation either lack sufficient spatial contexts or suffer from high GPU computational cost, which limits the performance. To tackle these issues, we propose…
Lesion synthesis received much attention with the rise of efficient generative models for augmenting training data, drawing lesion evolution scenarios, or aiding expert training. The quality and diversity of synthesized data are highly dependent on the annotated data used to train the models, which not rarely struggle to derive very different yet realistic samples from the training ones. That adds an inherent bias to lesion segmentation algorithms and limits synthesizing lesion evolution scenarios efficiently. This paper presents a method for decoupling shape and density for liver lesion synth…
PAII Inc.（PAII 公司）；Chang Gung Memorial Hospital（长庚纪念医院）；Ping An Technology Co., Ltd.（平安科技（深圳）有限公司）
Identifying, measuring and reporting lesions accurately and comprehensively from patient CT scans are important yet time-consuming procedures for physicians. Computer-aided lesion/significant-findings detection techniques are at the core of medical imaging, which remain very challenging due to the tremendously large variability of lesion appearance, location and size distributions in 3D imaging. In this work, we propose a novel deep anchor-free one-stage VULD framework that incorporates (1) P3DC operators to recycle the architectural configurations and pre-trained weights from the off-the-shel…
Università degli Studi di Genova（热那亚大学）；IRCCS San Martino Hospital（IRCCS圣马蒂诺医院）
Due to the need for quick and effective treatments for liver diseases, which are among the most common health problems in the world, staging fibrosis through non-invasive and economic methods has become of great importance. Taking inspiration from diagnostic laparoscopy, used in the past for hepatic diseases, in this paper ultrasound images of the liver are studied, focusing on a specific region of the organ where the Glisson's capsule is visible. In ultrasound images, the Glisson's capsule appears in the shape of a line which can be extracted via classical methods in literature. By making use…
Lesion detection is an important problem within medical imaging analysis. Most previous work focuses on detecting and segmenting a specialized category of lesions (e.g., lung nodules). However, in clinical practice, radiologists are responsible for finding all possible types of anomalies. The task of universal lesion detection (ULD) was proposed to address this challenge by detecting a large variety of lesions from the whole body. There are multiple heterogeneously labeled datasets with varying label completeness: DeepLesion, the largest dataset of 32,735 annotated lesions of various types, bu…
University Segalen Bordeaux（波尔多塞加朗大学）；CNRS（法国国家科学研究中心）；Image Sciences Institute（影像科学研究所）；University Medical Center Utrecht（乌得勒支大学医学中心）
High Intensity Focused Ultrasound (HIFU) can be used to achieve a local temperature increase deep inside the human body in a non-invasive way. MRI guidance of the procedure allows in situ target definition. In addition, MRI can be used to provide continuous temperature mapping during HIFU for spatial and temporal control of the heating procedure and prediction of the final lesion based on the received thermal dose. Temperature mapping of mobile organs as kidney and liver is challenging, as well as real-time processing methods for feedback control of the HIFU procedure. In this paper, recent te…
Technical University of Munich（慕尼黑工业大学）；University of Zurich（苏黎世大学）；Ecole Polytechnique de Montréal（蒙特利尔理工学院）；Tel-Aviv University（特拉维夫大学）；Imperial College London（帝国理工学院）；Hebrew University of Jerusalem（希伯来大学）；Radboud University Medical Center（拉德堡德大学医学中心）；The University of Montréal Hospital Research Centre（蒙特利尔大学医院研究中心）；LMU Munich（慕尼黑大学）
In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018. The image dataset is diverse and contains primary and secondary tumors with varied sizes and appearances with various lesion-to-background levels (hyper-/hypo-dense), created in collaboration with seven hospitals and research institutions. Seventy-five submitted liver and liv…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）
Extracting, harvesting and building large-scale annotated radiological image datasets is a greatly important yet challenging problem. It is also the bottleneck to designing more effective data-hungry computing paradigms (e.g., deep learning) for medical image analysis. Yet, vast amounts of clinical annotations (usually associated with disease image findings and marked using arrows, lines, lesion diameters, segmentation, etc.) have been collected over several decades and stored in hospitals' Picture Archiving and Communication Systems. In this paper, we mine and harvest one major type of clinic…
A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools
Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China（北京清华长庚医院病理科，临床医学学院，清华大学医学院，清华大学，北京，中国）；Shenzhen International Graduate School, Tsinghua University, Shenzhen, China（深圳国际研究生院，清华大学，深圳，中国）
Mask-guided Data Augmentation for Multiparametric MRI Generation with a Rare Hepatocellular Carcinoma
Universidad Industrial de Santander（桑坦德工业大学）；University of Toulouse（图卢兹大学）；Université Paul Sabatier Toulouse 3（图卢兹第三大学（保罗·萨巴蒂埃大学））；Bicêtre University Hospital（比塞特尔大学医院）；Assistance publique des hôpitaux de Paris（巴黎公共援助医院）；Université Claude Bernard Lyon 1（里昂第一大学（克洛德·贝尔纳里昂第一大学））
Inverse Bayesian Inference for Extracting Lesion Dynamics from Longitudinal Spectral CT
University Hospital Augsburg（奥格斯堡大学医院）；Technical University of Munich（慕尼黑工业大学）；Bavarian Center for Cancer Research (BZKF)（巴伐利亚癌症研究中心）；University of Augsburg（奥格斯堡大学）
