Valid belief updates for prequentially additive loss functions arising in Semi-Modular Inference

基于稀疏加性信念模型的知识梯度策略

The Knowledge Gradient Policy Using A Sparse Additive Belief Model

本文提出一种用于高维稀疏信念函数的序贯学习策略，结合贝叶斯R&S与频率学学习，通过B-样条基扩展和非参数加性模型实现稀疏线性模型参数估计。

A Knowledge Gradient Policy for Sequencing Experiments to Identify the Structure of RNA Molecules Using a Sparse Additive Belief Model

We present a sparse knowledge gradient (SpKG) algorithm for adaptively selecting the targeted regions within a large RNA molecule to identify which regions are most amenable to interactions with other molecules. Experimentally, such regions can be inferred from fluorescence measurements obtained by binding a complementary probe with fluorescence markers to the targeted regions. We use a biophysical model which shows that the fluorescence ratio under the log scale has a sparse linear relationship with the coefficients describing the accessibility of each nucleotide, since not all sites are acce…

Bayes posterior convergence for loss functions via almost additive Thermodynamic Formalism

Statistical inference can be seen as information processing involving input information and output information that updates belief about some unknown parameters. We consider the Bayesian framework for making inferences about dynamical systems from ergodic observations, where the Bayesian procedure is based on the Gibbs posterior inference, a decision process generalization of standard Bayesian inference where the likelihood is replaced by the exponential of a loss function. In the case of direct observation and almost-additive loss functions, we prove an exponential convergence of the a poster…

False confidence, non-additive beliefs, and valid statistical inference

Statistics has made tremendous advances since the times of Fisher, Neyman, Jeffreys, and others, but the fundamental and practically relevant questions about probability and inference that puzzled our founding fathers remain unanswered. To bridge this gap, I propose to look beyond the two dominating schools of thought and ask the following three questions: what do scientists need out of statistics, do the existing frameworks meet these needs, and, if not, how to fill the void? To the first question, I contend that scientists seek to convert their data, posited statistical model, etc., into cal…

Scalable Variational Bayesian Kernel Selection for Sparse Gaussian Process Regression

This paper presents a variational Bayesian kernel selection (VBKS) algorithm for sparse Gaussian process regression (SGPR) models. In contrast to existing GP kernel selection algorithms that aim to select only one kernel with the highest model evidence, our proposed VBKS algorithm considers the kernel as a random variable and learns its belief from data such that the uncertainty of the kernel can be interpreted and exploited to avoid overconfident GP predictions. To achieve this, we represent the probabilistic kernel as an additional variational variable in a variational inference (VI) framewo…

Incorporating genuine prior information about between-study heterogeneity in random effects pairwise and network meta-analyses

Background: Pairwise and network meta-analyses using fixed effect and random effects models are commonly applied to synthesise evidence from randomised controlled trials. The models differ in their assumptions and the interpretation of the results. The model choice depends on the objective of the analysis and knowledge of the included studies. Fixed effect models are often used because there are too few studies with which to estimate the between-study standard deviation from the data alone. Objectives: The aim is to propose a framework for eliciting an informative prior distribution for the be…