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arXiv 2201.07867q-bio.NCq-bio.QM
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人脑语音处理的空间尺度维

The spatial scale dimension of speech processing in the human brain

Philipp Kellmeyer, Roland Berkemeier, Tonio Ball

摘要:

在过去的三十年里,神经影像学为人类大脑的结构-功能关系提供了重要的见解。然而,最近,功能性磁共振成像(fMRI)数据的分析方法受到审查,研究质疑跨软件的可比性,统计推断和解释的有效性,以及空间滤波器大小对神经影像分析的影响。由于大多数fMRI研究仅使用单个滤波器进行分析,因此关于高斯尺度空间中BOLD信号的大小和形状的许多信息仍然隐藏,并限制了fMRI研究的解释。为了研究空间观察尺度对fMRI分析的影响,我们使用了一个空间多尺度分析与高斯滤波器的范围从1-20毫米(半高全宽),分析25名健康受试者的语音重复范式的fMRI数据。我们发现,分析功能磁共振成像数据的范围内的高斯滤波器内核揭示了大量的变化,在神经解剖定位和平均信号强度和大小的阈上集群取决于过滤器的大小。我们还演示了如何小的空间滤波器的结果偏向皮层下和小脑集群。此外,我们描述了皮质和小脑集群之间的规模依赖的集群大小动态有很大不同。我们将讨论如何空间多尺度分析可能会大大提高功能磁共振成像数据的解释。我们建议进一步发展空间多尺度分析,以充分探索BOLD信号在高斯尺度空间中的深层结构。

英文摘要:

In the past three decades, neuroimaging has provided important insights into structure-function relationships in the human brain. Recently, however, the methods for analyzing functional magnetic resonance imaging (fMRI) data have come under scrutiny, with studies questioning cross-software comparability, the validity of statistical inference and interpretation, and the influence of the spatial filter size on neuroimaging analyses. As most fMRI studies only use a single filter for analysis, much information on the size and shape of the BOLD signal in Gaussian scale space remains hidden and constrains the interpretation of fMRI studies. To investigate the influence of the spatial observation scale on fMRI analysis, we use a spatial multiscale analysis with a range of Gaussian filters from 1-20 mm (full width at half maximum) to analyze fMRI data from a speech repetition paradigm in 25 healthy subjects. We show that analyzing the fMRI data over a range of Gaussian filter kernels reveals substantial variability in the neuroanatomical localization and the average signal strength and size of suprathreshold clusters depending on the filter size. We also demonstrate how small spatial filters bias the results towards subcortical and cerebellar clusters. Furthermore, we describe substantially different scale-dependent cluster size dynamics between cortical and cerebellar clusters. We discuss how spatial multiscale analysis may substantially improve the interpretation of fMRI data. We propose to further develop a spatial multiscale analysis to fully explore the deep structure of the BOLD signal in Gaussian scale space.

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