Optimal Lockdown to Manage an Epidemic

Tracking the time course of reproduction number and lockdown's effect during SARS-CoV-2 epidemic: nonparametric estimation

Accurate modeling of lockdown effects on SARS-CoV-2 epidemic evolution is a key issue in order e.g. to inform health-care decisions on emergency management. The compartmental and spatial models so far proposed use parametric descriptions of the contact rate, often assuming a time-invariant effect of the lockdown. In this paper we show that these assumptions may lead to erroneous evaluations on the ongoing pandemic. Thus, we develop a new class of nonparametric compartmental models able to describe how the impact of the lockdown varies in time. Exploiting regularization theory, hospitalized dat…

COVID-19 epidemic control using short-term lockdowns for collective gain

While many efforts are currently devoted to vaccines development and administration, social distancing measures, including severe restrictions such as lockdowns, remain fundamental tools to contain the spread of COVID-19. A crucial point for any government is to understand, on the basis of the epidemic curve, the right temporal instant to set up a lockdown and then to remove it. Different strategies are being adopted with distinct shades of intensity. USA and Europe tend to introduce restrictions of considerable temporal length. They vary in time: a severe lockdown may be reached and then grad…

Optimal Lockdown Management using Short Term COVID-19 Prediction Model

This paper proposes optimal lockdown management policies based on short-term prediction of active COVID-19 confirmed cases to ensure the availability of critical medical resources. The optimal time to start the lockdown from the current time is obtained after maximizing a cost function considering economic value subject to constraints of availability of medical resources, and maximum allowable value of daily growth rate and Test Positive Ratio. The estimated value of required medical resources is calculated as a function of total active cases. The predicted value of active cases is calculated …

基于深度确定性策略梯度的大规模智能体流行病学模型中的疫情控制

Epidemic Control on a Large-Scale-Agent-Based Epidemiology Model using Deep Deterministic Policy Gradient

本研究利用深度确定性策略梯度（DDPG）在10万个体的大规模智能体流行病学模拟中实现多目标优化，确定封锁与疫苗接种的最优策略，以平衡经济与健康目标。

COVID-19 pandemic control: balancing detection policy and lockdown intervention under ICU sustainability

We consider here an extended SIR model, including several features of the recent COVID-19 outbreak: in particular the infected and recovered individuals can either be detected (+) or undetected (-) and we also integrate an intensive care unit (ICU) capacity. Our model enables a tractable quantitative analysis of the optimal policy for the control of the epidemic dynamics using both lockdown and detection intervention levers. With parametric specification based on literature on COVID-19, we investigate the sensitivities of various quantities on the optimal strategies, taking into account the su…

Mitigating Biological Epidemic on Heterogeneous Social Networks

Recent Covid-19 pandemic has demonstrated the need of efficient epidemic outbreak management. We study the optimal control problem of minimizing the fraction of infected population by applying vaccination and treatment control strategies, while at the same time minimizing the cost of implementing them. We model the epidemic using the degree based Susceptible-Infected-Recovered (SIR) compartmental model. We study the impact of varying network topologies on the optimal epidemic management strategies and present results for the Erdos-Renyi, scale free, and real world networks. For efficient compu…