Fiuncho：CPU簇中任意阶上位性检测程序
Fiuncho: a program for any-order epistasis detection in CPU clusters
摘要：
上位性可以定义为基因在表型表达过程中的统计相互作用。它被认为在基因表达中起着重要作用，因为在以前的全基因组关联研究中，个别遗传变异报告了疾病风险的非常小的增加。最成功的上位性检测方法是穷举法，尽管其指数时间复杂度要求高度并行的实现以便使用。这项工作提出了Fiuncho，一个程序，利用所有级别的并行存在于\textit{x86\_64} CPU集群，以减轻这种方法的复杂性。它支持任何顺序的上位性相互作用，与其他穷举方法相比，它平均分别比MDR，MPI3SNP和BitEpi快358，7和3倍。
英文摘要：
Epistasis can be defined as the statistical interaction of genes during the expression of a phenotype. It is believed that it plays a fundamental role in gene expression, as individual genetic variants have reported a very small increase in disease risk in previous Genome-Wide Association Studies. The most successful approach to epistasis detection is the exhaustive method, although its exponential time complexity requires a highly parallel implementation in order to be used. This work presents Fiuncho, a program that exploits all levels of parallelism present in \textit{x86\_64} CPU clusters in order to mitigate the complexity of this approach. It supports epistasis interactions of any order, and when compared with other exhaustive methods, it is on average 358, 7 and 3 times faster than MDR, MPI3SNP and BitEpi, respectively.
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