Exploring Longitudinal Cough, Breath, and Voice Data for COVID-19 Progression Prediction via Sequential Deep Learning: Model Development and Validation
University of Cambridge（剑桥大学）；University of Southampton（南安普顿大学）
Recent work has shown the potential of using audio data (eg, cough, breathing, and voice) in the screening for COVID-19. However, these approaches only focus on one-off detection and detect the infection given the current audio sample, but do not monitor disease progression in COVID-19. Limited exploration has been put forward to continuously monitor COVID-19 progression, especially recovery, through longitudinal audio data. Tracking disease progression characteristics could lead to more timely treatment.
The primary objective of this study is to explore the potential of longitudinal audio samples over time for COVID-19 progression prediction and, especially, recovery trend prediction using sequential deep learning techniques.
Crowdsourced respiratory audio data, including breathing, cough, and voice samples, from 212 individuals over 5-385 days were analyzed. We developed a deep learning-enabled tracking tool using gated recurrent units (GRUs) to detect COVID-19 progression by exploring the audio dynamics of the individuals' historical audio biomarkers. The investigation comprised 2 parts: (1) COVID-19 detection in terms of positive and negative (healthy) tests, and (2) longitudinal disease progression prediction over time in terms of probability of positive tests.
The strong performance for COVID-19 detection, yielding an AUROC of 0.79, a sensitivity of 0.75, and a specificity of 0.71 supported the effectiveness of the approach compared to methods that do not leverage longitudinal dynamics. We further examined the predicted disease progression trajectory, displaying high consistency with test results with a correlation of 0.75 in the test cohort and 0.86 in a subset of the test cohort who reported recovery. Our findings suggest that monitoring COVID-19 evolution via longitudinal audio data has potential in the tracking of individuals' disease progression and recovery.
University of Augsburg（奥格斯堡大学）；Imperial College London（帝国理工学院）
The COVID-19 pandemic has affected the world unevenly; while industrial economies have been able to produce the tests necessary to track the spread of the virus and mostly avoided complete lockdowns, developing countries have faced issues with testing capacity. In this paper, we explore the usage of deep learning models as a ubiquitous, low-cost, pre-testing method for detecting COVID-19 from audio recordings of breathing or coughing taken with mobile devices or via the web. We adapt an ensemble of Convolutional Neural Networks that utilise raw breathing and coughing audio and spectrograms to …
Stellenbosch University（斯泰伦博斯大学）；SAMRC Centre for Tuberculosis Research（南非医学研究理事会结核病研究中心）
We present an experimental investigation into the effectiveness of transfer learning and bottleneck feature extraction in detecting COVID-19 from audio recordings of cough, breath and speech. This type of screening is non-contact, does not require specialist medical expertise or laboratory facilities and can be deployed on inexpensive consumer hardware. We use datasets that contain recordings of coughing, sneezing, speech and other noises, but do not contain COVID-19 labels, to pre-train three deep neural networks: a CNN, an LSTM and a Resnet50. These pre-trained networks are subsequently eith…
Imperial College London（伦敦帝国理工学院）；University of Augsburg（奥格斯堡大学）；North Bristol NHS Trust（北布里斯托尔国民保健服务信托基金）
Our main contributions are as follows: (I) We demonstrate the first attempt to diagnose COVID-19 using end-to-end deep learning from a crowd-sourced dataset of audio samples, achieving ROC-AUC of 0.846; (II) Our model, the COVID-19 Identification ResNet, (CIdeR), has potential for rapid scalability, minimal cost and improving performance as more data becomes available. This could enable regular COVID-19 testing at apopulation scale; (III) We introduce a novel modelling strategy using a custom deep neural network to diagnose COVID-19 from a joint breath and cough representation; (IV) We release…
The COVID-19 pandemic created a significant interest and demand for infection detection and monitoring solutions. In this paper we propose a machine learning method to quickly triage COVID-19 using recordings made on consumer devices. The approach combines signal processing methods with fine-tuned deep learning networks and provides methods for signal denoising, cough detection and classification. We have also developed and deployed a mobile application that uses symptoms checker together with voice, breath and cough signals to detect COVID-19 infection. The application showed robust performan…
The issue in respiratory sound classification has attained good attention from the clinical scientists and medical researcher's group in the last year to diagnosing COVID-19 disease. To date, various models of Artificial Intelligence (AI) entered into the real-world to detect the COVID-19 disease from human-generated sounds such as voice/speech, cough, and breath. The Convolutional Neural Network (CNN) model is implemented for solving a lot of real-world problems on machines based on Artificial Intelligence (AI). In this context, one dimension (1D) CNN is suggested and implemented to diagnose …
In the break of COVID-19 pandemic, mass testing has become essential to reduce the spread of the virus. Several recent studies suggest that a significant number of COVID-19 patients display no physical symptoms whatsoever. Therefore, it is unlikely that these patients will undergo COVID-19 test, which increases their chances of unintentionally spreading the virus. Currently, the primary diagnostic tool to detect COVID-19 is RT-PCR test on collected respiratory specimens from the suspected case. This requires patients to travel to a laboratory facility to be tested, thereby potentially infectin…
The COVID-19 pandemic presents global challenges transcending boundaries of country, race, religion, and economy. The current gold standard method for COVID-19 detection is the reverse transcription polymerase chain reaction (RT-PCR) testing. However, this method is expensive, time-consuming, and violates social distancing. Also, as the pandemic is expected to stay for a while, there is a need for an alternate diagnosis tool which overcomes these limitations, and is deployable at a large scale. The prominent symptoms of COVID-19 include cough and breathing difficulties. We foresee that respira…
University of Science and Technology of China (USTC)（中国科学技术大学）；Institute of Acoustics, Chinese Academy of Sciences（中国科学院声学研究所）
In this work, we propose a bi-directional long short-term memory (BiLSTM) network based COVID-19 detection method using breath/speech/cough signals. By using the acoustic signals to train the network, respectively, we can build individual models for three tasks, whose parameters are averaged to obtain an average model, which is then used as the initialization for the BiLSTM model training of each task. This initialization method can significantly improve the performance on the three tasks, which surpasses the official baseline results. Besides, we also utilize a public pre-trained model wav2ve…
Verisk Analytics Inc.（维睿斯克分析公司）；Indian Institute of Science（印度科学学院）
This report describes the system used for detecting COVID-19 positives using three different acoustic modalities, namely speech, breathing, and cough in the second DiCOVA challenge. The proposed system is based on the combination of 4 different approaches, each focusing more on one aspect of the problem, and reaches the blind test AUCs of 86.41, 77.60, and 84.55, in the breathing, cough, and speech tracks, respectively, and the AUC of 85.37 in the fusion of these three tracks.
University of Cambridge（剑桥大学）；Alan Turing Institute（艾伦·图灵研究所）
Audio signals generated by the human body (e.g., sighs, breathing, heart, digestion, vibration sounds) have routinely been used by clinicians as indicators to diagnose disease or assess disease progression. Until recently, such signals were usually collected through manual auscultation at scheduled visits. Research has now started to use digital technology to gather bodily sounds (e.g., from digital stethoscopes) for cardiovascular or respiratory examination, which could then be used for automatic analysis. Some initial work shows promise in detecting diagnostic signals of COVID-19 from voice …
The current outbreak of a coronavirus, has quickly escalated to become a serious global problem that has now been declared a Public Health Emergency of International Concern by the World Health Organization. Infectious diseases know no borders, so when it comes to controlling outbreaks, timing is absolutely essential. It is so important to detect threats as early as possible, before they spread. After a first successful DiCOVA challenge, the organisers released second DiCOVA challenge with the aim of diagnosing COVID-19 through the use of breath, cough and speech audio samples. This work prese…
Zonguldak Bülent Ecevit University（宗古尔达克·比伦特·埃杰维特大学）；Eregli Iron and Steel Co.（埃雷利钢铁公司）
The disease called the new coronavirus (COVID19) is a new viral respiratory disease that first appeared on January 13, 2020 in Wuhan, China. Some of the symptoms of this disease are fever, cough, shortness of breath and difficulty in breathing. In more serious cases, death may occur as a result of infection. COVID19 emerged as a pandemic that affected the whole world in a little while. The most important issue in the fight against the epidemic is the early diagnosis and follow-up of COVID19 (+) patients. Therefore, in addition to the RT-PCR test, medical imaging methods are also used when iden…
Imperial College London（伦敦帝国理工学院）；North Bristol NHS Trust（北布里斯托尔国民健康服务体系信托基金）；University of Augsburg（奥格斯堡大学）
We report on cross-running the recent COVID-19 Identification ResNet (CIdeR) on the two Interspeech 2021 COVID-19 diagnosis from cough and speech audio challenges: ComParE and DiCOVA. CIdeR is an end-to-end deep learning neural network originally designed to classify whether an individual is COVID-positive or COVID-negative based on coughing and breathing audio recordings from a published crowdsourced dataset. In the current study, we demonstrate the potential of CIdeR at binary COVID-19 diagnosis from both the COVID-19 Cough and Speech Sub-Challenges of INTERSPEECH 2021, ComParE and DiCOVA. C…
The technology development for point-of-care tests (POCTs) targeting respiratory diseases has witnessed a growing demand in the recent past. Investigating the presence of acoustic biomarkers in modalities such as cough, breathing and speech sounds, and using them for building POCTs can offer fast, contactless and inexpensive testing. In view of this, over the past year, we launched the ``Coswara'' project to collect cough, breathing and speech sound recordings via worldwide crowdsourcing. With this data, a call for development of diagnostic tools was announced in the Interspeech 2021 as a spec…
Samsung Research and Development Institute Bangalore（三星班加罗尔研发院）
The COVID-19 pandemic has resulted in more than 125 million infections and more than 2.7 million casualties. In this paper, we attempt to classify covid vs non-covid cough sounds using signal processing and deep learning methods. Air turbulence, the vibration of tissues, movement of fluid through airways, opening, and closure of glottis are some of the causes for the production of the acoustic sound signals during cough. Does the COVID-19 alter the acoustic characteristics of breath, cough, and speech sounds produced through the respiratory system? This is an open question waiting for answers.…
University of Cambridge（剑桥大学）；University of Southampton（南安普顿大学）
Researchers have been battling with the question of how we can identify Coronavirus disease (COVID-19) cases efficiently, affordably and at scale. Recent work has shown how audio based approaches, which collect respiratory audio data (cough, breathing and voice) can be used for testing, however there is a lack of exploration of how biases and methodological decisions impact these tools' performance in practice. In this paper, we explore the realistic performance of audio-based digital testing of COVID-19. To investigate this, we collected a large crowdsourced respiratory audio dataset through …
In this study, a machine learning model was developed for automatically detecting respiratory system sounds such as sneezing and coughing in disease diagnosis. The automatic model and approach development of breath sounds, which carry valuable information, results in early diagnosis and treatment. A successful machine learning model was developed in this study, which was a strong response to the challenge called the "Pfizer digital medicine challenge" on the "OSFHOME" open access platform. "Environmental sound classification" called ESC-50 and AudioSet sound files were used to prepare the data…
The World Health Organization (WHO) has announced a COVID-19 was a global pandemic in March 2020. It was initially started in china in the year 2019 December and affected an expanding number of nations in various countries in the last few months. In this particular situation, many techniques, methods, and AI-based classification algorithms are put in the spotlight in reacting to fight against it and reduce the rate of such a global health crisis. COVID-19's main signs are heavy temperature, different cough, cold, breathing shortness, and a combination of loss of sense of smell and chest tightn…
The Second Diagnosis of COVID-19 using Acoustics (DiCOVA) Challenge aimed at accelerating the research in acoustics based detection of COVID-19, a topic at the intersection of acoustics, signal processing, machine learning, and healthcare. This paper presents the details of the challenge, which was an open call for researchers to analyze a dataset of audio recordings consisting of breathing, cough and speech signals. This data was collected from individuals with and without COVID-19 infection, and the task in the challenge was a two-class classification. The development set audio recordings we…
University of Augsburg（奥格斯堡大学）；Johannes Kepler University Linz（约翰内斯·开普勒林茨大学）；Imperial College London（帝国理工学院）
Detecting COVID-19 from audio signals, such as breathing and coughing, can be used as a fast and efficient pre-testing method to reduce the virus transmission. Due to the promising results of deep learning networks in modelling time sequences, and since applications to rapidly identify COVID in-the-wild should require low computational effort, we present a temporal-oriented broadcasting residual learning method that achieves efficient computation and high accuracy with a small model size. Based on the EfficientNet architecture, our novel network, named Temporal-oriented ResNet~(TorNet), consti…
MIT AutoID Laboratory（麻省理工学院自动识别实验室）；Harvard University（哈佛大学）；University of Edinburgh（爱丁堡大学）；University of Central Florida（中佛罗里达大学）；University of Milano-Bicocca（米兰比可卡大学）
We introduce a novel audio processing architecture, the Open Voice Brain Model (OVBM), improving detection accuracy for Alzheimer's (AD) longitudinal discrimination from spontaneous speech. We also outline the OVBM design methodology leading us to such architecture, which in general can incorporate multimodal biomarkers and target simultaneously several diseases and other AI tasks. Key in our methodology is the use of multiple biomarkers complementing each other, and when two of them uniquely identify different subjects in a target disease we say they are orthogonal. We illustrate the methodol…
University of Brighton（布莱顿大学）；Royal Holloway University of London（伦敦大学皇家霍洛威学院）
Audio classification using breath and cough samples has recently emerged as a low-cost, non-invasive, and accessible COVID-19 screening method. However, a comprehensive survey shows that no application has been approved for official use at the time of writing, due to the stringent reliability and accuracy requirements of the critical healthcare setting. To support the development of Machine Learning classification models, we performed an extensive comparative investigation and ranking of 15 audio features, including less well-known ones. The results were verified on two independent COVID-19 so…
UAEU（阿拉伯联合酋长国大学）；Staffordshire University（斯塔福德郡大学）；Tianjin University of Technology（天津理工大学）
Respiratory symptoms can be a caused by different underlying conditions, and are often caused by viral infections, such as Influenza-like illnesses or other emerging viruses like the Coronavirus. These respiratory viruses, often, have common symptoms, including coughing, high temperature, congested nose, and difficulty breathing. However, early diagnosis of the type of the virus, can be crucial, especially in cases such as the recent COVID-19 pandemic. One of the factors that contributed to the spread of the pandemic, was the late diagnosis or confusing it with regular flu-like symptoms. Scien…
University of Augsburg（奥格斯堡大学）；Universitat Pompeu Fabra（庞培法布拉大学）；Joint Research Centre, European Commission（欧盟委员会联合研究中心）；Imperial College London（帝国理工学院）
This work presents an outer product-based approach to fuse the embedded representations generated from the spectrograms of cough, breath, and speech samples for the automatic detection of COVID-19. To extract deep learnt representations from the spectrograms, we compare the performance of a CNN trained from scratch and a ResNet18 architecture fine-tuned for the task at hand. Furthermore, we investigate whether the patients' sex and the use of contextual attention mechanisms is beneficial. Our experiments use the dataset released as part of the Second Diagnosing COVID-19 using Acoustics (DiCOVA…
Respiratory rate (RR) is a clinical metric used to assess overall health and physical fitness. An individual's RR can change from their baseline due to chronic illness symptoms (e.g., asthma, congestive heart failure), acute illness (e.g., breathlessness due to infection), and over the course of the day due to physical exhaustion during heightened exertion. Remote estimation of RR can offer a cost-effective method to track disease progression and cardio-respiratory fitness over time. This work investigates a model-driven approach to estimate RR from short audio segments obtained after physical…
University of Essex（埃塞克斯大学）；Austrian Institute of Technology（奥地利技术研究所）；FPT Software Company Limited（FPT软件有限公司）
This paper evaluates a wide range of audio-based deep learning frameworks applied to the breathing, cough, and speech sounds for detecting COVID-19. In general, the audio recording inputs are transformed into low-level spectrogram features, then they are fed into pre-trained deep learning models to extract high-level embedding features. Next, the dimension of these high-level embedding features are reduced before finetuning using Light Gradient Boosting Machine (LightGBM) as a back-end classification. Our experiments on the Second DiCOVA Challenge achieved the highest Area Under the Curve (AUC…
Lately, there has been a global effort by multiple research groups to detect COVID-19 from voice. Different researchers use different kinds of information from the voice signal to achieve this. Various types of phonated sounds and the sound of cough and breath have all been used with varying degree of success in automated voice-based COVID-19 detection apps. In this paper, we show that detecting COVID-19 from voice does not require custom-made non-standard features or complicated neural network classifiers rather it can be successfully done with just standard features and simple binary classif…
Indian Institute of Science（印度科学学院）；P. D. Hinduja National Hospital and Medical Research Center（P. D. 印度教国家医院与医学研究中心）
The research direction of identifying acoustic bio-markers of respiratory diseases has received renewed interest following the onset of COVID-19 pandemic. In this paper, we design an approach to COVID-19 diagnostic using crowd-sourced multi-modal data. The data resource, consisting of acoustic signals like cough, breathing, and speech signals, along with the data of symptoms, are recorded using a web-application over a period of ten months. We investigate the use of statistical descriptors of simple time-frequency features for acoustic signals and binary features for the presence of symptoms. …
