分子复制子中达尔文选择的热力学
Thermodynamics of Darwinian selection in molecular replicators
AI总结：
本文揭示自催化分子复制子中适应度、复制速率与热力学亲和力之间的基本界限，并给出临界选择系数约束，为理解生命起源复制子的热力学限制提供理论框架。
摘要：
我们研究了自催化分子复制子中热力学、适应度与达尔文选择之间的关系。我们揭示了一个热力学界限，它将适应度、复制速率和复制的热力学亲和力联系起来。该界限适用于广泛的系统，包括基元和非基元自催化反应、基于聚合物的复制子以及某些类型的自催化集合。此外，我们表明临界选择系数（选择可见的最小适应度差异）由亲和力的一个简单函数界定。我们的结果意味着分子进化中选择强度存在基本热力学界限，这与有限种群规模和错误阈值产生的其他界限互补。这些界限可能与理解生命起源时早期复制子面临的热力学约束相关。我们通过若干例子说明我们的方法，包括恒化器中复制子的经典模型。
英文摘要：
We consider the relationship between thermodynamics, fitness, and Darwinian selection in autocatalytic molecular replicators. We uncover a thermodynamic bound that relates fitness, replication rate, and thermodynamic affinity of replication. This bound applies to a broad range of systems, including elementary and non-elementary autocatalytic reactions, polymer-based replicators, and certain kinds of autocatalytic sets. In addition, we show that the critical selection coefficient (the minimal fitness difference visible to selection) is bounded by a simple function of the affinity. Our results imply fundamental thermodynamic bounds on selection strength in molecular evolution, complementary to other bounds that arise from finite population sizes and error thresholds. These bounds may be relevant for understanding thermodynamic constraints faced by early replicators at the origin of life. We illustrate our approach on several examples, including a classic model of replicators in a chemostat.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
