The human gaze is a cost-efficient physiological data that reveals human underlying attentional patterns. The selective attention mechanism helps the cognition system focus on task-relevant visual clues by ignoring the presence of distractors. Thanks to this ability, human beings can efficiently learn from a very limited number of training samples. Inspired by this mechanism, we aim to leverage gaze for medical image analysis tasks with small training data. Our proposed framework includes a backbone encoder and a Selective Attention Network (SAN) that simulates the underlying attention. The SAN implicitly encodes information such as suspicious regions that is relevant to the medical diagnose tasks by estimating the actual human gaze. Then we design a novel Auxiliary Attention Block (AAB) to allow information from SAN to be utilized by the backbone encoder to focus on selective areas. Specifically, this block uses a modified version of a multi-head attention layer to simulate the human visual search procedure. Note that the SAN and AAB can be plugged into different backbones, and the framework can be used for multiple medical image analysis tasks when equipped with task-specific heads. Our method is demonstrated to achieve superior performance on both 3D tumor segmentation and 2D chest X-ray classification tasks. We also show that the estimated gaze probability map of the SAN is consistent with an actual gaze fixation map obtained by board-certified doctors.
Labeling medical images depends on professional knowledge, making it difficult to acquire large amount of annotated medical images with high quality in a short time. Thus, making good use of limited labeled samples in a small dataset to build a high-performance model is the key to medical image classification problem. In this paper, we propose a deeply supervised Layer Selective Attention Network (LSANet), which comprehensively uses label information in feature-level and prediction-level supervision. For feature-level supervision, in order to better fuse the low-level features and high-level f…
University of Georgia（佐治亚大学）；Zhongnan Hospital of Wuhan University（武汉大学中南医院）；Shanghai Jiao Tong University（上海交通大学）
In this paper we consider the problem of unsupervised anomaly segmentation in medical images, which has attracted increasing attention in recent years due to the expensive pixel-level annotations from experts and the existence of a large amount of unannotated normal and abnormal image scans. We introduce a segmentation network that utilizes adversarial learning to partition an image into two cuts, with one of them falling into a reference distribution provided by the user. This Adversarial-based Selective Cutting network (ASC-Net) bridges the two domains of cluster-based deep segmentation and …
Stanford University（斯坦福大学）；Harvard T.H. Chan School of Public Health（哈佛陈曾熙公共卫生学院）
We propose a selective learning method using meta-learning and deep reinforcement learning for medical image interpretation in the setting of limited labeling resources. Our method, MedSelect, consists of a trainable deep learning selector that uses image embeddings obtained from contrastive pretraining for determining which images to label, and a non-parametric selector that uses cosine similarity to classify unseen images. We demonstrate that MedSelect learns an effective selection strategy outperforming baseline selection strategies across seen and unseen medical conditions for chest X-ray …
SeVeR: Selective Visual Exposure and Retrieval for 3D Medical Image Question Answering
DAMO Academy, Alibaba Group（阿里巴巴达摩院）；College of Computer Science and Technology, Zhejiang University（浙江大学计算机科学与技术学院）；Hupan Lab（湖畔实验室）；School of Public Health, Zhejiang University（浙江大学公共卫生学院）
I2I-Mamba: Multi-modal medical image synthesis via selective state space modeling
Department of Electrical and Electronics Engineering, and National Magnetic Resonance Research Center, Bilkent University（电子工程系和国家磁共振研究中心，比尔肯特大学）；Department of Electrical Engineering, Stanford University（电气工程系，斯坦福大学）
Technion – Israel Institute of Technology（以色列理工学院）
Medical imaging analysis plays a critical role in the diagnosis and treatment of various medical conditions. This paper focuses on chest X-ray images and their corresponding radiological reports. It presents a new model that learns a joint X-ray image & report representation. The model is based on a novel alignment scheme between the visual data and the text, which takes into account both local and global information. Furthermore, the model integrates domain-specific information of two types -- lateral images and the consistent visual structure of chest images. Our representation is shown to b…
Brain Tumor Classification using Vision Transformer with Selective Cross-Attention Mechanism and Feature Calibration
K.N. Toosi University of Technology（霍梅尼国际大学（K.N. Toosi理工大学））；Indiana University-Purdue University（印第安纳大学-普渡大学）；Shahed university（沙希德大学）；University of Cincinnati（辛辛那提大学）
Unlike natural images, medical images often have intrinsic characteristics that can be leveraged for neural network learning. For example, images that belong to different stages of a disease may continuously follow a certain progression pattern. In this paper, we propose a novel method that leverages disease progression learning for medical image recognition. In our method, sequences of images ordered by disease stages are learned by a neural network that consists of a shared vision model for feature extraction and a long short-term memory network for the learning of stage sequences. Auxiliary…
Less is More: Selective Reduction of CT Data for Self-Supervised Pre-Training of Deep Learning Models with Contrastive Learning Improves Downstream Classification Performance
Ulm University（乌尔姆大学）；Ulm University Medical Center（乌尔姆大学医学中心）
Siemens Healthineers（西门子医疗）；University of Michigan（密歇根大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
The interpretation of medical images is a challenging task, often complicated by the presence of artifacts, occlusions, limited contrast and more. Most notable is the case of chest radiography, where there is a high inter-rater variability in the detection and classification of abnormalities. This is largely due to inconclusive evidence in the data or subjective definitions of disease appearance. An additional example is the classification of anatomical views based on 2D Ultrasound images. Often, the anatomical context captured in a frame is not sufficient to recognize the underlying anatomy. …
Selective experience replay compression using coresets for lifelong deep reinforcement learning in medical imaging
Rice University（莱斯大学）；McGovern Medical School, UTHealth Houston（德克萨斯大学健康科学中心休斯顿麦戈文医学院）；The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）；University of Maryland School of Medicine（马里兰大学医学院）
The Pennsylvania State University（宾夕法尼亚州立大学）；National Institutes of Health（美国国立卫生研究院）
Supervised training of an automated medical image analysis system often requires a large amount of expert annotations that are hard to collect. Moreover, the proportions of data available across different classes may be highly imbalanced for rare diseases. To mitigate these issues, we investigate a novel data augmentation pipeline that selectively adds new synthetic images generated by conditional Adversarial Networks (cGANs), rather than extending directly the training set with synthetic images. The selection mechanisms that we introduce to the synthetic augmentation pipeline are motivated by…
Enhancing Medical Imaging with GANs Synthesizing Realistic Images from Limited Data
Columbia University（哥伦比亚大学）；Texas Tech University（德克萨斯理工大学）；University of California, Davis（加利福尼亚大学戴维斯分校）；Johns Hopkins University（约翰斯·霍普金斯大学）；North Carolina State University（北卡罗来纳州立大学）
Stanford University（斯坦福大学）；School of Medicine, Stanford University（斯坦福大学医学院）
Self-supervised contrastive learning between pairs of multiple views of the same image has been shown to successfully leverage unlabeled data to produce meaningful visual representations for both natural and medical images. However, there has been limited work on determining how to select pairs for medical images, where availability of patient metadata can be leveraged to improve representations. In this work, we develop a method to select positive pairs coming from views of possibly different images through the use of patient metadata. We compare strategies for selecting positive pairs for ch…
Reconstructing medical images from partial measurements is an important inverse problem in Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing solutions based on machine learning typically train a model to directly map measurements to medical images, leveraging a training dataset of paired images and measurements. These measurements are typically synthesized from images using a fixed physical model of the measurement process, which hinders the generalization capability of models to unknown measurement processes. To address this issue, we propose a fully unsupervised techniq…
Peking University（北京大学）；Peking University Health Science Center（北京大学医学部）；Peking University Shenzhen Graduate School（北京大学深圳研究生院）；Shenzhen Bay Laboratory（深圳湾实验室）；Beijing Cancer Hospital & Institute（北京肿瘤医院暨研究所）
Purpose: Deep neural networks (DNNs) have been widely applied in medical image classification, benefiting from its powerful mapping capability among medical images. However, these existing deep learning-based methods depend on an enormous amount of carefully labeled images. Meanwhile, noise is inevitably introduced in the labeling process, degrading the performance of models. Hence, it's significant to devise robust training strategies to mitigate label noise in the medical image classification tasks. Methods: In this work, we propose a novel Bayesian statistics guided label refurbishment mech…
Sheikh Zayed Institute of Pediatric and Surgical Innovation（谢赫·扎耶德儿科与外科创新研究所）；George Washington University（乔治华盛顿大学）
State-of-the-art methods for object detection use region proposal networks (RPN) to hypothesize object location. These networks simultaneously predicts object bounding boxes and \emph{objectness} scores at each location in the image. Unlike natural images for which RPN algorithms were originally designed, most medical images are acquired following standard protocols, thus organs in the image are typically at a similar location and possess similar geometrical characteristics (e.g. scale, aspect-ratio, etc.). Therefore, medical image acquisition protocols hold critical localization and geometric…
The ability to quickly annotate medical imaging data plays a critical role in training deep learning frameworks for segmentation. Doing so for image volumes or video sequences is even more pressing as annotating these is particularly burdensome. To alleviate this problem, this work proposes a new method to efficiently segment medical imaging volumes or videos using point-wise annotations only. This allows annotations to be collected extremely quickly and remains applicable to numerous segmentation tasks. Our approach trains a deep learning model using an appropriate Positive/Unlabeled objectiv…
University of Guelph（圭尔夫大学）；Vector Institute（向量研究所）；Canadian Institute for Advanced Research（加拿大高等研究院）
The use of deep learning for medical imaging has seen tremendous growth in the research community. One reason for the slow uptake of these systems in the clinical setting is that they are complex, opaque and tend to fail silently. Outside of the medical imaging domain, the machine learning community has recently proposed several techniques for quantifying model uncertainty (i.e.~a model knowing when it has failed). This is important in practical settings, as we can refer such cases to manual inspection or correction by humans. In this paper, we aim to bring these recent results on estimating u…
Leveraging Medical Foundation Model Features in Graph Neural Network-Based Retrieval of Breast Histopathology Images
Artificial Intelligence Department, Faculty of Computer Engineering, University of Isfahan, Isfahan, Iran；Department of Computer Engineering Techniques, Mazaya University College, Nasiriyah, Iraq；Department of Medicine, Danube Private University, Krems an der Donau, Austria；Austrian Center for Medical Innovation；Research Center for Medical Image Analysis；Artificial Intelligence, Department of Medicine, Danube Private University, Krems an der Donau, Austria
Information Technology University（信息技术大学）；University of Toronto（多伦多大学）
Among the plethora of techniques devised to curb the prevalence of noise in medical images, deep learning based approaches have shown the most promise. However, one critical limitation of these deep learning based denoisers is the requirement of high-quality noiseless ground truth images that are difficult to obtain in many medical imaging applications such as X-rays. To circumvent this issue, we leverage recently proposed approach of [7] that incorporates Stein's Unbiased Risk Estimator (SURE) to train a deep convolutional neural network without requiring denoised ground truth X-ray data. Our…
Leveraging Pre-trained Models for Robust Federated Learning for Kidney Stone Type Recognition
CINVESTAV（墨西哥国立理工研究中心）；Universidad Nacional de Ingenieria（国立工程大学）；Tecnologico de Monterrey（蒙特雷科技大学）；CRAN UMR 7039（CRAN研究中心）；Université de Lorraine（洛林大学）；CNRS（法国国家科学研究中心）
Adapting Medical Vision Foundation Models for Volumetric Medical Image Segmentation via Active Learning and Selective Semi-supervised Fine-tuning
Mallinckrodt Institute of Radiology（马林克罗德放射医学研究所）；Institute for Informatics, Data Science and Biostatistics（信息学、数据科学与生物统计学研究所）；Department of Radiology, Perelman School of Medicine（放射科，佩尔曼医学院）；Center for AI and Data Science for Integrated Diagnostics (AI2D)（集成诊断人工智能与数据科学中心（AI2D））
Medical image segmentation has been widely recognized as a pivot procedure for clinical diagnosis, analysis, and treatment planning. However, the laborious and expensive annotation process lags down the speed of further advances. Contrastive learning-based weight pre-training provides an alternative by leveraging unlabeled data to learn a good representation. In this paper, we investigate how contrastive learning benefits the general supervised medical segmentation tasks. To this end, patch-dragsaw contrastive regularization (PDCR) is proposed to perform patch-level tugging and repulsing with …
SAMed-2: Selective Memory Enhanced Medical Segment Anything Model
Lehigh University, Bethlehem, PA, USA（莱斯大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Georgia, Athens, GA, USA（佐治亚大学）；University of Notre Dame, Notre Dame, IN, USA（Notre Dame 大学）
University of New South Wales（新南威尔士大学）；COMSATS University Islamabad（伊斯兰堡通信卫星大学）
Recent progress in encoder-decoder neural network architecture design has led to significant performance improvements in a wide range of medical image segmentation tasks. However, state-of-the-art networks for a given task may be too computationally demanding to run on affordable hardware, and thus users often resort to practical workarounds by modifying various macro-level design aspects. Two common examples are downsampling of the input images and reducing the network depth to meet computer memory constraints. In this paper we investigate the effects of these changes on segmentation performa…
Wuhan University（武汉大学）；Renmin Hospital of Wuhan University（武汉大学人民医院）；Xi’an Aeronautical University（西安航空学院）
Automated medical image segmentation plays an important role in many clinical applications, which however is a very challenging task, due to complex background texture, lack of clear boundary and significant shape and texture variation between images. Many researchers proposed an encoder-decoder architecture with skip connections to combine low-level feature maps from the encoder path with high-level feature maps from the decoder path for automatically segmenting medical images. The skip connections have been shown to be effective in recovering fine-grained details of the target objects and ma…
