蛋白质--和谐的庆典
Proteins -- a celebration of consilience
摘要：
蛋白质是所有活细胞的共同组成部分。它们是分子机器，彼此之间以及与其他细胞产物相互作用，并以独特的方式执行令人眼花缭乱的功能。这些相互作用遵循其天然状态结构，因此理解序列-结构关系具有根本重要性。关于蛋白质，值得注意的是，对它们的理解必然跨越几个学科。几何学在定义蛋白质天然状态结构中的重要性，数学和物理学对蛋白质行为的约束，蛋白质遵守量子化学定律的必要性，以及进化和生物学的丰富作用，都在定义蛋白质科学中聚集在一起。在这里，我们回顾了文献中的思想，并提出了一个跨学科的框架，旨在将柏拉图和达尔文的思想结合起来，并在描述蛋白质时展示了学科之间惊人的一致性。我们讨论了这个框架对蛋白质行为的影响。
英文摘要：
Proteins are the common constituents of all living cells. They are molecular machines that interact with each other as well as with other cell products and carry out a dizzying array of functions with distinction. These interactions follow from their native state structures and therefore understanding sequence-structure relationships is of fundamental importance. What is quite remarkable about proteins is that their understanding necessarily straddles several disciplines. The importance of geometry in defining protein native state structure, the constraints placed on protein behavior by mathematics and physics, the need for proteins to obey the laws of quantum chemistry, and the rich role of evolution and biology all come together in defining protein science. Here we review ideas from the literature and present an interdisciplinary framework that aims to marry ideas from Plato and Darwin and demonstrates an astonishing consilience between disciplines in describing proteins. We discuss the consequences of this framework on protein behavior.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
