病毒感染性在溶瘤病毒治疗结果中的作用：一项数学研究
The role of viral infectivity in oncolytic virotherapy outcomes: A mathematical study
摘要：
一个模型捕捉病毒和肿瘤细胞之间的动态溶瘤病毒治疗的背景下，提出和分析。病毒被未感染细胞内化的能力由感染性参数描述，该参数从可用的实验数据推断。该参数还能够描述影响肿瘤细胞病毒摄取的肿瘤环境变化的影响。结果表明，当一种病毒被接种到一个正在生长的肿瘤内时，增强感染性的策略并不能完全根除肿瘤。在实验和治疗的典型时间内，我们观察到振荡的开始，这总是阻止肿瘤块的完全破坏。这些发现与现有的实验室结果吻合良好。进一步的分析表明，为什么一个完全成功的治疗不能存在所提出的模型，必须小心时，设计和工程病毒载体增强功能。特别是，分叉分析表明，创造更持久的病毒颗粒或使用减少感染细胞寿命的策略可能会导致总体肿瘤负荷随时间推移出现意外和不必要的激增。我们的研究结果表明，单独的病毒治疗似乎不太可能是有效的，在临床环境中，除非包括辅助策略。
英文摘要：
A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by uninfected cells is described by an infectivity parameter, which is inferred from available experimental data. The parameter is also able to describe the effects of changes in the tumour environment that affect viral uptake from tumour cells. Results show that when a virus is inoculated inside a growing tumour, strategies for enhancing infectivity do not lead to a complete eradication of the tumour. Within typical times of experiments and treatments, we observe the onset of oscillations, which always prevent a full destruction of the tumour mass. These findings are in good agreement with available laboratory results. Further analysis shows why a fully successful therapy cannot exist for the proposed model and that care must be taken when designing and engineering viral vectors with enhanced features. In particular, bifurcation analysis reveals that creating longer lasting virus particles or using strategies for reducing infected cell lifespan can cause unexpected and unwanted surges in the overall tumour load over time. Our findings suggest that virotherapy alone seems unlikely to be effective in clinical settings unless adjuvant strategies are included.
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