arXivDaily arXiv每日学术速递 周一至周五更新
arXiv周末暂无论文更新,休息一下吧,周末愉快~~
arXiv 2109.08981q-bio.CB
收藏

极化细胞中的运动转换和前后同步

Motility switching and front-back synchronisation in polarized cells

Gissell Estrada-Rodriguez, Benoit Perthame

摘要:

极化细胞运动中突出和收缩的组合可以帮助我们了解细胞两端之间可能同步的影响。这种同步,反过来,可能导致不同的动态,如正常和分数扩散。从一个随机的单细胞轨迹,记忆效应诱导持续运动出发,我们推导出一个在介观尺度的动力学更新系统。我们研究了不同复杂程度的各种场景,其中细胞的两端独立移动或部分或完全同步。我们研究相关的宏观限制,我们获得扩散,漂移扩散或分数扩散,这取决于初始系统。本文阐明了描述细胞同步运动可能影响的相关宏观方程的形式,并阐明了正常扩散和分数扩散之间的转换

英文摘要:

The combination of protrusions and retractions in the movement of polarized cells leads to understand the effect of possible synchronisation between the two ends of the cells. This synchronisation, in turn, could lead to different dynamics such as normal and fractional diffusion. Departing from a stochastic single cell trajectory, where a memory effect induces persistent movement, we derive a kinetic-renewal system at the mesoscopic scale. We investigate various scenarios with different levels of complexity, where the two ends of the cell move either independently or with partial or full synchronisation. We study the relevant macroscopic limits where we obtain diffusion, drift-diffusion or fractional diffusion, depending on the initial system. This article clarifies the form of relevant macroscopic equations that describe the possible effects of synchronised movement in cells, and sheds light on the switching between normal and fractional diffusion

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑