液体肝脏体模：模拟人体肝脏的粘弹性色散，用于超声和MRI中的弹性成像
Liquid-liver phantom: mimicking the viscoelastic dispersion of human liver for elastography in ultrasound and MRI
摘要：
不同的临床弹性成像设备在同一受试者中显示不同的肝脏硬度值，这阻碍了值的比较和用于疾病检测的系统独立阈值的建立。因此，当局要求标准化的幻影，解决粘度相关的分散度的刚度超过频率。线性聚合聚丙烯酰胺体模（PAAm）校准健康人体肝脏在体内的粘弹性。通过剪切流变仪、基于超声的时间谐波弹性成像、临床MR弹性成像（MRE）和桌面MRE在5 Hz至3000 Hz频率范围内量化剪切波速作为刚度的替代。超声成像参数与活体肝脏接近。评估了再现性、老化行为和温度依赖性，并满足定量弹性成像的要求。此外，该体模被用来表征几种临床弹性成像方法的剪切波速的频带宽度。液体肝脏体模对于肝脏弹性成像的标准化和开发具有有利的特性：首先，它可以在超声和MRI中的临床和实验弹性成像设备中使用。其次，作为液体，它可以很容易地在尺寸和形状上适应特定的技术要求，并通过添加夹杂物和散射体。最后，由于体模是基于非交联线性PAA成分，它很容易生产，这表明研究人员和供应商之间的潜在广泛使用，以标准化肝脏硬度测量。
英文摘要：
Different clinical elastography devices show different liver-stiffness values in the same subject, hindering comparison of values and establishment of system-independent thresholds for disease detection. Therefore, authorities request standardized phantoms that address the viscosity-related dispersion of stiffness over frequency. A linear polymerized polyacrylamide phantom (PAAm) was calibrated to the viscoelastic properties of healthy human liver in vivo. Shear-wave speed as a surrogate of stiffness was quantified between 5 Hz and 3000 Hz frequency-range by shear rheometry, ultrasound-based time-harmonic elastography, clinical MR elastography (MRE), and tabletop MRE. Imaging parameters for ultrasound were close to those of liver in vivo. Reproducibility, aging behavior and temperature dependency were assessed and fulfilled requirements for quantitative elastography. In addition, the phantom was used to characterize the frequency bandwidth of shear-wave speed of several clinical elastography methods. The liquid-liver phantom has favorable properties for standardization and development of liver elastography: first, it can be used across clinical and experimental elastography devices in ultrasound and MRI. Second, being a liquid, it can easily be adapted in size and shape to specific technical requirements, and by adding inclusions and scatterers. Finally, since the phantom is based on non-crosslinked linear PAA constituents, it is easy to produce, indicating potential widespread use among researchers and vendors to standardize liver-stiffness measurements.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
