确定离体皮肤的光学特性：逆解
Determining optical properties of skin ex-vivo: An inverse solution
摘要：
输运方程的快速精确数值解（即，反相加加倍）的漫反射率已被用于计算尤卡坦小型猪皮作为人类替代皮肤的光学性质。该方法适用于各种光学特性，并可适用于各种探头几何形状，前提是进行了校准测量。逆加法加倍（IAD）是基于输运方程的正解的数值解，其中光学性质可以用作计算混浊介质的其他性质的先验。在这项工作中，积分球与安装激光二极管和单色器被实验用作照射源。使用冷冻切片机精确切片组织样品。共聚焦和原子力显微镜的光学方法被用来可视化组织照射后。这项工作的结果提供了一个额外的方法来确定生物组织的光学特性。
英文摘要：
A rapid and accurate numerical solution to the transport equation (i.e., inverse adding doubling) of diffuse reflectance has been utilized here for the calculation of optical properties of the Yucatan miniature pigskin as human surrogate skin. This method is valid for a wide range of optical properties and can be adapted to a variety of probe geometries, provided calibration measurements are made. Inverse adding doubling (IAD), based on the forward solution to the transport equation is a numerical solution in which optical properties can be used as a prior for computing other properties for turbid media. In this work, integrating spheres with fitted laser diodes and a monochromator was used experimentally as the irradiation source. A cryo-microtome was used to precisely slice tissue samples. Confocal and atomic force microscopy optical methods were used to visualize tissue post-irradiation. The results from this work offer an additional method to determine the optical properties of biological tissues.
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