Flagellar length control in multiflagellated eukaryotes: a case study with Giardia

英文摘要：

Every organism has a size that is convenient for its function. Not only multicellular organisms but also uni-cellular organisms and even subcellular structures have convenient sizes. Flagella of eukaryotic cells are long dynamic cell protrusions. Because of their simple linear geometry, these cell appendages have been popular system for experimental investigation of the mechanisms of size control of organelles of eukaryotic cells. In the past most of the attention have been focussed on mono-flagellates and bi-flagellates. By extending our earlier model of bi-flagellates, here we develop a theoretical model for flagellar length control in {\it Giardia} which is an octo-flagellate. It has four pairs of flagella of four different lengths. Analyzing our model we predict the different sizes of the four pairs of flagella . This analysis not only provide insight into the physical origins of the different lengths but the predicted lengths are also consistent with the experimental data.