Fe_3O_4/Au-Ag@MoS_2纳米粒子治疗脑肿瘤的磁等离子体研究
Characterization of Fe_3 O_4/Au-Ag@MoS_2 nanoparticles for brain cancer treatment using magneto plasmonic approach
摘要：
本研究旨在探讨以Fe_3O_4为核、金、银合金为壳、二硫化钼为包覆层的纳米粒子，通过磁热疗法治疗脑癌。这些纳米粒子在肿瘤内的光学性质，包括消光系数和表面等离子体激元峰（SPR）的大小，结构，不同的组合物，和厚度的函数也使用有效介质理论进行了研究。此外，温度分布的影响进行了评估，通过分析建模的交流（AC）磁场。实验结果表明，由Fe_3O_4-Au_（0.25）Ag_（0.75）@MoS_2组成的复合纳米粒子，厚度为3 nm的金银合金和3层MoS_2组成的复合纳米粒子在生物窗内具有最佳的消光系数和SPR。金银合金提高了消光系数，同时防止了磁性纳米颗粒的积累。由于单独的金银合金不能在生物窗口范围内起作用，因此使用MoS_2，这增加了在较高波长下的消光效率。对所提出的合金化合物的肿瘤中的温度分布的检查表明，在从照射开始的短时间之后，肿瘤温度达到45 ℃。肿瘤组织内的温度分布在肿瘤中心达到最大值，随着远离中心温度分布急剧下降。磁热疗的使用使得能够将治疗剂量局部递送到恶性脑肿瘤;因此，表现出优于光热方法的性能/效率。
英文摘要：
This study investigates the treatment of brain cancer by the magnetic hyperthermia approach and nanoparticles including Fe_3 O_4 core with gold, silver alloy shell, and MoS_2 coating. Optical properties of these nanoparticles within the tumor, including the extinction coefficient and surface plasmon peak (SPR) as a function of size, structure, different compositions, and thickness are also investigated using the effective medium theory. Moreover, the impact of temperature distribution was assessed through the analytical modeling of alternating current (AC) magnetic field. The results of this study indicated that nanoparticles with a compound of Fe_3 O_4 - Au_0.25 Ag_0.75@MoS_2 and a thickness of 3 nm of gold-silver alloy and 3 layers of MoS_2 have the best coefficient of extinction and SPR in the biological window. The gold-silver alloy improved the extinction coefficient and, at the same time, prevented the accumulation of magnetic nanoparticles. Since the gold-silver alloy alone cannot function within the range of biological windows, MoS_2 was used, which increased the extinction efficiency at higher wavelengths. Examination of the temperature distribution in the tumor for the proposed alloy compound indicated that after a short time from the start of irradiation, the tumor temperature reaches 45 C degree. Also, the temperature distribution within the tumor tissue reached its maximum value at the center of the tumor and decreased dramatically as getting away from the center. The use of magnetic hyperthermia enabled localized delivery of therapeutic dose to malignant brain tumors; hence, exhibiting superior performance/efficiency over the photothermal method.
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