多发性硬化中颈段脊髓扩散MRI测量的可重复性与演变
Reproducibility and Evolution of Diffusion MRI Measurements within the Cervical Spinal Cord in Multiple Sclerosis
AI总结：
本文研究多发性硬化中颈段脊髓扩散MRI指标随疾病进展的变化，通过测试-重测验证DTI和Ball-and-Stick模型的可重复性，并量化31名患者M0至M12的病理演变。
摘要：
在多发性硬化（MS）中，临床观察与病理在脑部图像上的表现之间存在巨大差异，这被称为临床-放射学悖论（CRP）。一种假设是，临床功能缺陷可能更多地与脊髓损伤有关，而非脑内病灶的数量或位置。因此，研究脊髓的损伤方式成为更好地理解和克服CRP的迫切挑战。已知扩散MRI能够提供大脑以及脊髓中神经元变性和轴突丢失的定量指标。在本文中，我们提出研究随着疾病的进展，扩散MRI指标在不同颈段区域的变化情况。我们首先采用测试-重测程序，使用标准扩散张量成像（DTI）和多隔室Ball-and-Stick模型，研究扩散MRI在健康志愿者中的可重复性。随后，基于测试-重测的定量校准，我们在31名MS患者中提供了M0至M12期间颈椎的病理演变定量指标，展示了病理损伤在颈段脊髓中的分布情况。
英文摘要：
In Multiple Sclerosis (MS), there is a large discrepancy between the clinical observations and how the pathology is exhibited on brain images, this is known as the clinical-radiological paradox (CRP). One of the hypotheses is that the clinical deficit may be more related to the spinal cord damage than the number or location of lesions in the brain. Therefore, investigating how the spinal cord is damaged becomes an acute challenge to better understand and overcome the CRP. Diffusion MRI is known to provide quantitative figures of neuronal degeneration and axonal loss, in the brain as well as in the spinal cord. In this paper, we propose to investigate how diffusion MRI metrics vary in the different cervical regions with the progression of the disease. We first study the reproducibility of diffusion MRI on healthy volunteers with a test-retest procedure using both standard diffusion tensor imaging (DTI) and multi-compartment Ball-and-Stick models. Then, based on the test re-test quantitative calibration, we provide quantitative figures of pathology evolution between M0 and M12 in the cervical spine on a set of 31 MS patients, exhibiting how the pathology damage spans in the cervical spinal cord.
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