Breast cancer is one of the factors that cause the increase of mortality of women. The most widely used method for diagnosing this geological disease i.e. breast cancer is the ultrasound scan. Several key features such as the smoothness and the texture of the tumor captured through ultrasound scans encode the abnormality of the breast tumors (malignant from benign). However, ultrasound scans are often noisy and include irrelevant parts of the breast that may bias the segmentation of eventual tumors. In this paper, we are going to extract the region of interest ( i.e, bounding boxes of the tumors) and feed-forward them to one semantic segmentation encoder-decoder structure based on its classification (i.e, malignant or benign). the whole process aims to build an instance-based segmenter from a semantic segmenter and an object detector.
Breast tumor segmentation provides accurate tumor boundary, and serves as a key step toward further cancer quantification. Although deep learning-based approaches have been proposed and achieved promising results, existing approaches have difficulty in detecting small breast tumors. The capacity to detecting small tumors is particularly important in finding early stage cancers using computer-aided diagnosis (CAD) systems. In this paper, we propose a novel deep learning architecture called Small Tumor-Aware Network (STAN), to improve the performance of segmenting tumors with different size. The…
University of Idaho（爱达荷大学）；University of Utah School of Medicine（犹他大学医学院）
Breast tumor segmentation is a critical task in computer-aided diagnosis (CAD) systems for breast cancer detection because accurate tumor size, shape and location are important for further tumor quantification and classification. However, segmenting small tumors in ultrasound images is challenging, due to the speckle noise, varying tumor shapes and sizes among patients, and the existence of tumor-like image regions. Recently, deep learning-based approaches have achieved great success for biomedical image analysis, but current state-of-the-art approaches achieve poor performance for segmenting …
Comparative Analysis of Segment Anything Model and U-Net for Breast Tumor Detection in Ultrasound and Mammography Images
Florida Atlantic University（佛罗里达大西洋大学）；University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校）；Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）；Missouri University of Science and Technology（密苏里科技大学）；Florida International University（佛罗里达国际大学）
University of Delaware（特拉华大学）；University of Guilan（吉兰大学）；Eindhoven University of Technology（埃因霍温理工大学）；Iran University of Science and Technology（伊朗科学技术大学）
Automated 3-D breast ultrasound (ABUS) is a newfound system for breast screening that has been proposed as a supplementary modality to mammography for breast cancer detection. While ABUS has better performance in dense breasts, reading ABUS images is exhausting and time-consuming. So, a computer-aided detection system is necessary for interpretation of these images. Mass segmentation plays a vital role in the computer-aided detection systems and it affects the overall performance. Mass segmentation is a challenging task because of the large variety in size, shape, and texture of masses. Moreov…
Utah State University（犹他州立大学）；Harbin Institute of Technology（哈尔滨工业大学）；the First Affiliated Hospital of Harbin Medical University（哈尔滨医科大学附属第一医院）
Breast cancer is one of the most serious disease affecting women's health. Due to low cost, portable, no radiation, and high efficiency, breast ultrasound (BUS) imaging is the most popular approach for diagnosing early breast cancer. However, ultrasound images are low resolution and poor quality. Thus, developing accurate detection system is a challenging task. In this paper, we propose a fully automatic segmentation algorithm consisting of two parts: fuzzy fully convolutional network and accurately fine-tuning post-processing based on breast anatomy constraints. In the first part, the image i…
Harbin Institute of Technology（哈尔滨工业大学）；University of Idaho（爱达荷大学）；Utah State University（犹他州立大学）；Affiliated Hospital of Medical College Qingdao University（青岛大学医学院附属医院）；Second Hospital of Hebei Medical University（河北医科大学第二医院）
Breast ultrasound (BUS) image segmentation is challenging and critical for BUS Comput-er-Aided Diagnosis (CAD) systems. Many BUS segmentation approaches have been studied in the last two decades, but the performances of most approaches have been assessed using relatively small private datasets with different quantitative metrics, which results in a discrepancy in performance comparison. Therefore, there is a pressing need for building a benchmark to compare existing methods using a public dataset objectively, to determine the performance of the best breast tumor segmentation algorithm availabl…
Alzahra University（阿尔扎赫拉大学）；The University of Winnipeg（温尼伯大学）；Shahid Beheshti University of Medical Science（沙希德·贝赫什提医科大学）
The automatic analysis of subtle changes between longitudinal MR images is an important task as it is still a challenging issue in scope of the breast medical image processing. In this paper we propose an effective automatic change detection framework composed of two phases since previously used methods have features with low distinctive power. First, in the preprocessing phase an intensity normalization method is suggested based on Hierarchical Histogram Matching (HHM) that is more robust to noise than previous methods. To eliminate undesirable changes and extract the regions containing signi…
Data Science Institute, Imperial College London（伦敦帝国理工学院数据科学研究所）；National Heart and Lung Institute, Imperial College London（伦敦帝国理工学院国家心肺研究所）
A major challenge in brain tumor treatment planning and quantitative evaluation is determination of the tumor extent. The noninvasive magnetic resonance imaging (MRI) technique has emerged as a front-line diagnostic tool for brain tumors without ionizing radiation. Manual segmentation of brain tumor extent from 3D MRI volumes is a very time-consuming task and the performance is highly relied on operator's experience. In this context, a reliable fully automatic segmentation method for the brain tumor segmentation is necessary for an efficient measurement of the tumor extent. In this study, we p…
The Chinese University of Hong Kong（香港中文大学）；University of Cambridge（剑桥大学）；Inception Institute of Artificial Intelligence（启迪人工智能研究院）；The Hong Kong University of Science and Technology（香港科技大学）；Jinan University（暨南大学）；Southern University of Science and Technology（南方科技大学）；Chinese Academy of Sciences（中国科学院）
Automatic breast lesion segmentation in ultrasound helps to diagnose breast cancer, which is one of the dreadful diseases that affect women globally. Segmenting breast regions accurately from ultrasound image is a challenging task due to the inherent speckle artifacts, blurry breast lesion boundaries, and inhomogeneous intensity distributions inside the breast lesion regions. Recently, convolutional neural networks (CNNs) have demonstrated remarkable results in medical image segmentation tasks. However, the convolutional operations in a CNN often focus on local regions, which suffer from limit…
We present Spectral GUI, a multiplatform breast MR image analysis tool designed to facilitate the segmentation of fibro glandular tissues and lesions in T1 weighted breast MR images via a graphical user interface (GUI). Spectral GUIR uses spectrum loft method [1] for breast MR image segmentation. Not only is it interactive, but robust and expeditious at the same time. Being devoid of any machine learning algorithm, it shows exceptionally high execution speed with minimal overheads. The accuracy of the results has been simultaneously measured using performance metrics and expert entailment. The…
Nankai University（南开大学）；Civil Aviation General Hospital（民航总医院）；Chinese PLA General Hospital（中国人民解放军总医院）
Breast lesions segmentation is an important step of computer-aided diagnosis system, and it has attracted much attention. However, accurate segmentation of malignant breast lesions is a challenging task due to the effects of heterogeneous structure and similar intensity distributions. In this paper, a novel bidirectional aware guidance network (BAGNet) is proposed to segment the malignant lesion from breast ultrasound images. Specifically, the bidirectional aware guidance network is used to capture the context between global (low-level) and local (high-level) features from the input coarse sal…
University of Idaho（爱达荷大学）；Utah State University（犹他州立大学）；Harbin Institute of Technology（哈尔滨工业大学）
Breast cancer is one of the leading causes of cancer death among women worldwide. In clinical routine, automatic breast ultrasound (BUS) image segmentation is very challenging and essential for cancer diagnosis and treatment planning. Many BUS segmentation approaches have been studied in the last two decades, and have been proved to be effective on private datasets. Currently, the advancement of BUS image segmentation seems to meet its bottleneck. The improvement of the performance is increasingly challenging, and only few new approaches were published in the last several years. It is the time…
Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Weill Cornell Graduate School for Medical Sciences（威尔康奈尔医学研究生院）
Pathologic analysis of surgical excision specimens for breast carcinoma is important to evaluate the completeness of surgical excision and has implications for future treatment. This analysis is performed manually by pathologists reviewing histologic slides prepared from formalin-fixed tissue. In this paper, we present Deep Multi-Magnification Network trained by partial annotation for automated multi-class tissue segmentation by a set of patches from multiple magnifications in digitized whole slide images. Our proposed architecture with multi-encoder, multi-decoder, and multi-concatenation out…
NVIDIA（英伟达）；University of California, Los Angeles（加州大学洛杉矶分校）
Automated segmentation of kidneys and kidney tumors is an important step in quantifying the tumor's morphometrical details to monitor the progression of the disease and accurately compare decisions regarding the kidney tumor treatment. Manual delineation techniques are often tedious, error-prone and require expert knowledge for creating unambiguous representation of kidneys and kidney tumors segmentation. In this work, we propose an end-to-end boundary aware fully Convolutional Neural Networks (CNNs) for reliable kidney and kidney tumor semantic segmentation from arterial phase abdominal 3D CT…
Hybrid Attention Network for Accurate Breast Tumor Segmentation in Ultrasound Images
School of Information Engineering, Xi’an Eurasia University（信息工程学院，西安欧亚大学）；Department of Computer Science, University of Engineering and Technology Lahore（计算机科学系，拉合尔工程科技大学）
University of Arkansas at Little Rock（阿肯色大学小石城分校）；University of Illinois at Chicago（伊利诺伊大学芝加哥分校）
We propose a new model-based computer-aided diagnosis (CAD) system for tumor detection and classification (cancerous v.s. benign) in breast images. Specifically, we show that (x-ray, ultrasound and MRI) images can be accurately modeled by two-dimensional autoregressive-moving average (ARMA) random fields. We derive a two-stage Yule-Walker Least-Squares estimates of the model parameters, which are subsequently used as the basis for statistical inference and biophysical interpretation of the breast image. We use a k-means classifier to segment the breast image into three regions: healthy tissue,…
Towards Affordable Tumor Segmentation and Visualization for 3D Breast MRI Using SAM2
Center for Biosystems and Biotech Data Science, Ghent University Global Campus, Incheon, Republic of Korea（生物系统与生物技术数据科学中心，格罗宁根大学全球校园，韩国Incheon）；Department of Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium（数学、计算机科学与统计学系，格罗宁根大学，比利时Ghent）；IDLab, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium（IDLab，电子与信息系统系，格罗宁根大学，比利时Ghent）
Automating tumor-infiltrating lymphocyte assessment in breast cancer histopathology images using QuPath: a transparent and accessible machine learning pipeline
UiT The Arctic University of Norway（挪威北极圈大学）；University Hospital of North Norway（挪威北部大学医院）
The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction
Barcelona Artificial Intelligence in Medicine Lab (BCN-AIM), Facultat de Matemàtiques i Informàtica, Universitat de Barcelona（巴塞罗那人工智能在医学实验室（BCN-AIM），巴塞罗那大学数学与计算机学院）
Computer-aided detection (CAD) of benign and malignant breast lesions becomes increasingly essential in breast ultrasound (US) imaging. The CAD systems rely on imaging features identified by the medical experts for their performance, whereas deep learning (DL) methods automatically extract features from the data. The challenge of the DL is the insufficiency of breast US images available to train the DL models. Here, we present an ensemble transfer learning model to classify benign and malignant breast tumors using B-mode breast US (B-US) and strain elastography breast US (SE-US) images. This m…
Experts' cognition-driven safe noisy labels learning for precise segmentation of residual tumor in breast cancer
Institute of Clinical Pathology, West China Hospital, Sichuan University（四川大学华西医院临床病理研究所）；Zhongjiu Flash Medical Technology Co., Ltd.（中久闪医科技有限公司）；McGill University（麦吉尔大学）
Comparing Conditional Diffusion Models for Synthesizing Contrast-Enhanced Breast MRI from Pre-Contrast Images
Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Spain（巴塞罗那大学数学与计算机系）；Parc Taulí Hospital Universitari, Spain（帕尔克·塔利大学医院）；Hospital Germans Trias i Pujol, Spain（加泰罗尼亚Trias i Pujol医院）；Siemens Healthineers, America, LAM（西门子医疗）；Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain（加泰罗尼亚高级研究与教育研究所）；Computer Vision Center, Bellaterra, Spain（计算机视觉中心）
Deep learning-based classification of breast cancer molecular subtypes from H&E whole-slide images
Uit The Arctic University of Norway（挪威北极大学）；University Hospital of North Norway（北挪威大学医院）；Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）；Oslo University Hospital（奥斯陆大学医院）
BreastSegNet: Multi-label Segmentation of Breast MRI
Department of Biostatistics \& Bioinformatics, Duke University Department of Electrical；Computer Engineering, Duke University Department of Radiology, Duke University Medical Center Department of Computer Science, Duke University
The University of Texas at San Antonio（德克萨斯大学圣安东尼奥分校）；The University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Evolution Online LLC（Evolution Online有限责任公司）
We investigated the data-driven relationship between features in the tumor microenvironment (TME) and the overall and 5-year survival in triple-negative breast cancer (TNBC) and non-TNBC (NTNBC) patients by using Explainable Artificial Intelligence (XAI) models. We used clinical information from patients with invasive breast carcinoma from The Cancer Genome Atlas and from two studies from the cbioPortal, the PanCanAtlas project and the GDAC Firehose study. In this study, we used a normalized RNA sequencing data-driven cohort from 1,015 breast cancer patients, alive or deceased, from the UCSC X…
Breast cancer is in the most common malignant tumor in women. It accounted for 30% of new malignant tumor cases. Although the incidence of breast cancer remains high around the world, the mortality rate has been continuously reduced. This is mainly due to recent developments in molecular biology technology and improved level of comprehensive diagnosis and standard treatment. Early detection by mammography is an integral part of that. The most common breast abnormalities that may indicate breast cancer are masses and calcifications. Previous detection approaches usually obtain relatively high s…
The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）
Purpose-Optimal use of established and imaging methods, such as multiparametric magnetic resonance imaging(mpMRI) can simultaneously identify key functional parameters and provide unique imaging phenotypes of breast cancer. Therefore, we have developed and implemented a new machine-learning informatic system that integrates clinical variables, derived from imaging and clinical health records, to compare with the 21-gene array assay, OncotypeDX. Materials and methods-We tested our informatics modeling in a subset of patients (n=81) who had ER+ disease and underwent OncotypeDX gene expression an…
With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try to remain current. One example involves increasing usage of biomarkers when characterizing the pathologic prognostic stage of a breast tumor. We present our semantic technology approach to support cancer characterization and demonstrate it in our end-to-end prototype system that collects the newest breast cancer staging criteria from authoritative oncology …
