The Epilepsies are a common, chronic neurological disorder affecting more than 50 million individuals across the globe. It is characterized by unprovoked, recurring (similar or different type) seizures which are commonly diagnosed through clinical EEGs. Good-quality, open-access and free EEG data can act as a catalyst for on-going state-of-the-art (SOTA) research works for detection, prediction and management of epilepsy and seizures. They can also aid in improving the quality of life (QOL) of these diseased individuals and contribute research in healthcare multimedia, data analytics and Artificial Intelligence (AI) in personalized medicine. This paper presents widely used, available, open and free EEG datasets available for epilepsy and seizure diagnosis. A brief comparison and discussion of open and private datasets has also been done. Such datasets will help in development and evaluation of automatic computer-aided system in healthcare.
Tokyo University of Agriculture and Technology（东京农工大学）；Juntendo University Nerima Hospital（顺天堂大学练马医院）
Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It is thus crucial to develop automated models for the detection of abnormalities in EEGs related to epilepsy. This paper describes the development of a novel class of compact convolutional neural networks (CNNs) for detecting abnormal patterns and electrodes in EEGs for epilepsy. The designed model is inspired by a CNN developed for brain-computer interfacing called multichannel EEGNet (mEEGNet). Unlike the EEGNet, the proposed model, mEEGNet, has the sa…
St. Joseph’s College of Engineering（圣约瑟夫工程学院）；Texas A&M University-Commerce（德州农工大学Commerce分校）；Beirut Arab University（贝鲁特阿拉伯大学）；Anna University（安娜大学）
This paper evaluates the approach of imaging timeseries data such as EEG in the diagnosis of epilepsy through Deep Neural Network (DNN). EEG signal is transformed into an RGB image using Gramian Angular Summation Field (GASF). Many such EEG epochs are transformed into GASF images for the normal and focal EEG signals. Then, some of the widely used Deep Neural Networks for image classification problems are used here to detect the focal GASF images. Three pre-trained DNN such as the AlexNet, VGG16, and VGG19 are validated for epilepsy detection based on the transfer learning approach. Furthermore…
Frankfurt Institute for Advanced Studies (FIAS)（法兰克福高等研究院（FIAS））；Goethe University Frankfurt（法兰克福歌德大学）；Center for Personalized Translational Epilepsy Research (CePTER)（个性化转化癫痫研究中心（CePTER））；Oscar Langendorff Institute of Physiology, Rostock University Medical Center（罗斯托克大学医学中心奥斯卡·朗根多夫生理研究所）；Royal College of Surgeons Ireland（爱尔兰皇家外科医学院）
Epilepsy is one of the most common neurological disorders, affecting about 1% of the population at all ages. Detecting the development of epilepsy, i.e., epileptogenesis (EPG), before any seizures occur could allow for early interventions and potentially more effective treatments. Here, we investigate if modern machine learning (ML) techniques can detect EPG from intra-cranial electroencephalography (EEG) recordings prior to the occurrence of any seizures. For this we use a rodent model of epilepsy where EPG is triggered by electrical stimulation of the brain. We propose a ML framework for EPG…
Frankfurt Institute for Advanced Studies (FIAS)（法兰克福高等研究院）；Goethe University Frankfurt（法兰克福大学）；Center for Personalized Translational Epilepsy Research (CePTER)（个性化转化癫痫研究中心）
Epilepsy is the fourth most common neurological disorder, affecting about 1% of the population at all ages. As many as 60% of people with epilepsy experience focal seizures which originate in a certain brain area and are limited to part of one cerebral hemisphere. In focal epilepsy patients, a precise surgical removal of the seizure onset zone can lead to effective seizure control or even a seizure-free outcome. Thus, correct identification of the seizure onset zone is essential. For clinical evaluation purposes, electroencephalography (EEG) recordings are commonly used. However, their interpr…
Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of brain cells. Hence, seizure identification has great importance in clinical therapy of epileptic patients. Electroencephalogram (EEG) is one of the main biomarker that can measure voltage fluctuations of the brain and EEG data analysis helps to investigate the patient with epilepsy syndrome as epilepsy leaves their signature in EEG signals. In this paper, the Di…
The use of Multi-domain Electroencephalogram Representations in the building of Models based on Convolutional and Recurrent Neural Networks for Epilepsy Detection
Computer Science Department, Federal University of Ouro Preto（欧鲁普雷图联邦大学计算机科学系）
ETH Zürich（苏黎世联邦理工学院）；University of Bologna（博洛尼亚大学）；University of Modena and Reggio Emilia（摩德纳-雷焦艾米利亚大学）；Lausanne University Hospital (CHUV)（洛桑大学医院（CHUV））
We present the implementation of seizure detection algorithms based on a minimal number of EEG channels on a parallel ultra-low-power embedded platform. The analyses are based on the CHB-MIT dataset, and include explorations of different classification approaches (Support Vector Machines, Random Forest, Extra Trees, AdaBoost) and different pre/post-processing techniques to maximize sensitivity while guaranteeing no false alarms. We analyze global and subject-specific approaches, considering all 23-electrodes or only 4 temporal channels. For 8s window size and subject-specific approach, we repo…
PaperNet: Efficient Temporal Convolutions and Channel Residual Attention for EEG Epilepsy Detection
Rajshahi University of Engineering \& Technology, Kazla, Rajshahi-6204, Bangladesh BRAC University, Kha 224 Pragati Sarani, Merul Badda, Dhaka 1212, Bangladesh University of Asia Pacific, 74/A, Green Road, Dhaka-1205, Bangladesh
Epilepsy affects about 1% of the population every year, and is characterized by abnormal and sudden hyper-synchronous excitation of the neurons in the brain. The electroencephalogram(EEG) is the most widely used method to record brain signals and diagnose epilepsy and seizure cases. In this paper we use the method of Variational Mode Decomposition (VMD) in our analysis to classify seizure/seizure free signals. This technique uses variational non recursive mode decomposition, in comparison to other methods like Empirical Mode (EMD) and Hilbert-Huang transform which recursively decompose the sig…
Federal University of Technology（联邦理工大学）；University of São Paulo（圣保罗大学）
Epilepsy is one of the most common neurological disorders that can be diagnosed through electroencephalogram (EEG), in which the following epileptic events can be observed: pre-ictal, ictal, post-ictal, and interictal. In this paper, we present a novel method for epilepsy detection into two differentiation contexts: binary and multiclass classification. For feature extraction, a total of 105 measures were extracted from power spectrum, spectrogram, and bispectrogram. For classifier building, eight different machine learning algorithms were used. Our method was applied in a widely used EEG data…
São Carlos School of Engineering（圣卡洛斯工程学院）；University of São Paulo（圣保罗大学）；Istituto Italiano di Tecnologia（意大利技术研究院）；Medical School of Ribeirão Preto（里贝朗普雷图医学院）
Epilepsy is one of the most common neurological diseases, characterized by transient and unprovoked events called epileptic seizures. Electroencephalogram (EEG) is an auxiliary method used to perform both the diagnosis and the monitoring of epilepsy. Given the unexpected nature of an epileptic seizure, its prediction would improve patient care, optimizing the quality of life and the treatment of epilepsy. Predicting an epileptic seizure implies the identification of two distinct states of EEG in a patient with epilepsy: the preictal and the interictal. In this paper, we developed two deep lear…
A Novel TSK Fuzzy System Incorporating Multi-view Collaborative Transfer Learning for Personalized Epileptic EEG Detection
School of Artificial Intelligence and Computer Science, Jiangnan University and Engineering Research Center of Intelligent Technology for Healthcare, Ministry of Education（江南大学人工智能与计算机科学学院，智能医疗技术工程研究中心，教育部）；School of Computer and Information Engineering, Institute for Artificial Intelligence, Shanghai Polytechnic University（上海理工大学计算机与信息工程学院，人工智能研究院）；School of Internet of Things Engineering, Wuxi University（无锡大学物联网工程学院）
In recent years, multiple noninvasive imaging modalities have been used to develop a better understanding of the human brain functionality, including positron emission tomography, single-photon emission computed tomography, and functional magnetic resonance imaging, all of which provide brain images with millimeter spatial resolutions. Despite good spatial resolution, time resolution of these methods are poor and values are about seconds. Electroencephalography (EEG) is a popular non-invasive electrophysiological technique of relatively very high time resolution which is used to measure electr…
Electroencephalography (EEG), as the most common tool for epileptic seizure classification, contains useful information about different physiological states of the brain. Seizure related features in EEG signals can be better identified when localized in time frequency basis projections. In this work, a novel method for epileptic seizure classification based on wavelet packets (WPs) is presented in which both mother wavelet function and WP bases are adapted a posteriori to improve the seizure classification. A support vector machine (SVM) as classifier is used for seizure versus non-seizure EEG…
We propose a novel Coupled Hidden Markov Model to detect epileptic seizures in multichannel electroencephalography (EEG) data. Our model defines a network of seizure propagation paths to capture both the temporal and spatial evolution of epileptic activity. To address the intractability introduced by the coupled interactions, we derive a variational inference procedure to efficiently infer the seizure evolution from spectral patterns in the EEG data. We validate our model on EEG aquired under clinical conditions in the Epilepsy Monitoring Unit of the Johns Hopkins Hospital. Using 5-fold cross …
Epilepsy is a brain disorder due to abnormalactivity of neurons and recording of seizures is of primary interest in the evaluation of epileptic patients. A seizureis the phenomenon of rhythmicity discharge from either a local area or the whole brain and the individual behavior usually lasts from seconds to minutes.In this work, empirical wavelet transform(EWT) is applied to decompose signals into Electroencephalography (EEG) rhythms. EEG signals are separated to delta, theta, alpha, beta and gamma rhythms using EWT.The proposed method has been evaluated by benchmark dataset which is freely dow…
Epilepsy is a chronic neurological disorder affecting 1\% of people worldwide, deep learning (DL) algorithms-based electroencephalograph (EEG) analysis provides the possibility for accurate epileptic seizure (ES) prediction, thereby benefiting patients suffering from epilepsy. To identify the preictal region that precedes the onset of seizure, a large number of annotated EEG signals are required to train DL algorithms. However, the scarcity of seizure onsets leads to significant insufficiency of data for training the DL algorithms. To overcome this data insufficiency, in this paper, we propose…
ETH Zürich（苏黎世联邦理工学院）；University of Bologna（博洛尼亚大学）；University of Modena and Reggio Emilia（摩德纳-雷焦艾米利亚大学）
In the context of epilepsy monitoring, EEG artifacts are often mistaken for seizures due to their morphological similarity in both amplitude and frequency, making seizure detection systems susceptible to higher false alarm rates. In this work we present the implementation of an artifact detection algorithm based on a minimal number of EEG channels on a parallel ultra-low-power (PULP) embedded platform. The analyses are based on the TUH EEG Artifact Corpus dataset and focus on the temporal electrodes. First, we extract optimal feature models in the frequency domain using an automated machine le…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for neurological-disease diagnosis, the sensitivity of EEG-based expert visual diagnosis remains at $\sim$50\%. This indicates a clear need for advanced methodology to reduce the false negative rate in detecting abnormal scalp-EEGs. In that context, we focus on the problem of distinguishing the abnormal scalp EEGs of patients with neurological diseases, which were originally…
Epilepsy Seizure Detection and Prediction using an Approximate Spiking Convolutional Transformer
Institute of Neuroinformatics, University of Zurich and ETH Zurich（苏黎世大学与苏黎世联邦理工学院神经信息学研究所）；Delft University of Technology（代尔夫特理工大学）；School of Electronic Science and Technology, Nanjing University（南京大学电子科学与技术学院）
Electroencephalogram (EEG) is a common tool used to understand brain activities. The data are typically obtained by placing electrodes at the surface of the scalp and recording the oscillations of currents passing through the electrodes. These oscillations can sometimes lead to various interpretations, depending on the subject's health condition, the experiment carried out, the sensitivity of the tools used, human manipulations etc. The data obtained over time can be considered a time series. There is evidence in the literature that epilepsy EEG data may be chaotic. Either way, the embedding t…
BioSensics LLC（BioSensics有限责任公司）；Brown University（布朗大学）；University of Southern California（南加州大学）
Epilepsy is one of the most common neurological disorders, typically observed via seizure episodes. Epileptic seizures are commonly monitored through electroencephalogram (EEG) recordings due to their routine and low expense collection. The stochastic nature of EEG makes seizure identification via manual inspections performed by highly-trained experts a tedious endeavor, motivating the use of automated identification. The literature on automated identification focuses mostly on supervised learning methods requiring expert labels of EEG segments that contain seizures, which are difficult to obt…
Canine EEG Helps Human: Cross-Species and Cross-Modality Epileptic Seizure Detection via Multi-Space Alignment
Ministry of Education Key Laboratory of Image Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology（教育部图像处理与智能控制重点实验室，人工智能与自动化学院，华中科技大学）；Hubei Key Laboratory of Brain-inspired Intelligent Systems, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology（湖北省脑启发智能系统重点实验室，人工智能与自动化学院，华中科技大学）
School of Life Science, Beijing Institute of Technology（北京理工大学生命学院）
As the second most common neurodegenerative disease, Parkinson's disease has caused serious problems worldwide. However, the cause and mechanism of PD are not clear, and no systematic early diagnosis and treatment of PD have been established. Many patients with PD have not been diagnosed or misdiagnosed. In this paper, we proposed an EEG-based approach to diagnosing Parkinson's disease. It mapped the frequency band energy of electroencephalogram(EEG) signals to 2-dimensional images using the interpolation method and identified classification using capsule network(CapsNet) and achieved 89.34% c…
Controlling the surrounding world and predicting future events has always seemed like a dream, but that could become a reality using a Brain-Computer/Machine Interface (BCI/BMI). Epilepsy is a group of neurological diseases characterized by epileptic seizures. It affects millions of people worldwide, with 80 percent of cases occurring in developing countries. This can result in accidents and sudden, unexpected death. Seizures can happen undetectably in newborns, comatose, or motor-impaired patients, especially due to the fact that many medical personnel is not qualified for EEG signal analysis…
Institute of Neuroinformatics, University of Zurich and ETH Zurich（苏黎世大学与苏黎世联邦理工学院神经信息学研究所）；UniversitätsSpital und Universität Zürich（苏黎世大学医院与苏黎世大学）
In this work, we present a neuromorphic system that combines for the first time a neural recording headstage with a signal-to-spike conversion circuit and a multi-core spiking neural network (SNN) architecture on the same die for recording, processing, and detecting High Frequency Oscillations (HFO), which are biomarkers for the epileptogenic zone. The device was fabricated using a standard 0.18$μ$m CMOS technology node and has a total area of 99mm$^{2}$. We demonstrate its application to HFO detection in the iEEG recorded from 9 patients with temporal lobe epilepsy who subsequently underwent …
Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter many challenges in real-life situations. The EEGs are non-stationary signals and seizure patterns vary across patients and recording sessions. Moreover, EEG data are prone to numerous noise types that negatively affect the detection accuracy of epileptic seizures. To address these challenges, we introduce the use of a deep learning-based approach that autom…
Objective: The detection of epileptic seizures from scalp electroencephalogram (EEG) signals can facilitate early diagnosis and treatment. Previous studies suggested that the Gaussianity of EEG distributions changes depending on the presence or absence of seizures; however, no general EEG signal models can explain such changes in distributions within a unified scheme. Methods: This paper describes the formulation of a stochastic EEG model based on a multivariate scale mixture distribution that can represent changes in non-Gaussianity caused by stochastic fluctuations in EEG. In addition, we pr…
Comparison of Epilepsy Induced by Ischemic Hypoxic Brain Injury and Hypoglycemic Brain Injury using Multilevel Fusion of Data Features
Dijlah University College（迪吉拉大学学院）；Mazaya University College（马扎亚大学学院）；South Valley University（南谷大学）；Buraydah Private Colleges（布赖代私立学院）；Gulf University（海湾大学）；Northampton University（北安普顿大学）；Alturath University College（图拉斯大学学院）；Alfarahidi University（法拉希迪大学）；The Islamic University（伊斯兰大学）；Al-Kitab University（基塔布大学）；Al-Mustaqbal University College（穆斯塔克巴尔大学学院）；Universiti Teknikal Malaysia Melaka（马六甲马来西亚技术大学）；National University of Science and Technology（国立科技大学）
Electroencephalogram (EEG) monitoring and objective seizure identification is an essential clinical investigation for some patients with epilepsy. Accurate annotation is done through a time-consuming process by EEG specialists. Computer-assisted systems for seizure detection currently lack extensive clinical utility due to retrospective, patient-specific, and/or irreproducible studies that result in low sensitivity or high false positives in clinical tests. We aim to significantly reduce the time and resources on data annotation by demonstrating a continental generalization of seizure detectio…
Epilepsy Center Frankfurt（法兰克福癫痫中心）；Rhine-Main Neurocenter（莱茵-美因神经中心）
Epilepsy is a common neurological disorder characterized by recurrent seizures accompanied by excessive synchronous brain activity. The process of structural and functional brain alterations leading to increased seizure susceptibility and eventually spontaneous seizures is called epileptogenesis (EPG) and can span months or even years. Detecting and monitoring the progression of EPG could allow for targeted early interventions that could slow down disease progression or even halt its development. Here, we propose an approach for staging EPG using deep neural networks and identify potential ele…
Technische Hochschule Aschaffenburg（阿沙芬堡应用技术大学）；Universidade de São Paulo (USP)（圣保罗大学）
Mental disorders are among the leading causes of disability worldwide. The first step in treating these conditions is to obtain an accurate diagnosis, but the absence of established clinical tests makes this task challenging. Machine learning algorithms can provide a possible solution to this problem, as we describe in this work. We present a method for the automatic diagnosis of mental disorders based on the matrix of connections obtained from EEG time series and deep learning. We show that our approach can classify patients with Alzheimer's disease and schizophrenia with a high level of accu…
Baylor College of Medicine（贝勒医学院）；Michael E. DeBakey VA Medical Center（迈克尔·E·德贝基退伍军人事务医疗中心）
The Early diagnosis and treatment of depression is essential for effective treatment. Depression, while being one of the most common mental illnesses, is still poorly understood in both research and clinical practice. Among different treatments, drug prescription is widely used, however the drug treatment is not effective for many patients. In this work, we propose a method for major depressive disorder (MDD) diagnosis as well as a method for predicting the drug response in patient with MDD using EEG signals. Method: We employ transformers, which are modified recursive neural networks with nov…
Currently, strokes are the leading cause of adult disability in the United States. Traditional treatment and rehabilitation options such as physical therapy and tissue plasminogen activator are limited in their effectiveness and ability to restore mobility and function to the patient. As a result, there exists an opportunity to greatly improve the treatment for strokes. Machine learning, specifically techniques that utilize Brain-Computer Interfaces (BCIs) to help the patient either restore neurologic pathways or effectively communicate with an electronic prosthetic, show promising results whe…
Epilepsy is a chronic neurological disorder affecting more than 65 million people worldwide and manifested by recurrent unprovoked seizures. The unpredictability of seizures not only degrades the quality of life of the patients, but it can also be life-threatening. Modern systems monitoring electroencephalography (EEG) signals are being currently developed with the view to detect epileptic seizures in order to alert caregivers and reduce the impact of seizures on patients' quality of life. Such seizure detection systems employ state-of-the-art machine learning algorithms that require a conside…
A Hybrid Deep Spatio-Temporal Attention-Based Model for Parkinson's Disease Diagnosis Using Resting State EEG Signals
École de technologie supérieure (ÉTS), Université du Québec（魁北克大学高等技术学院）；Dibrugarh University（Dibrugarh大学）；Vytautas Magnus University（维陶塔斯马格努斯大学）；University of Southern Queensland（南昆士兰大学）
K. N. Toosi University of Technology（K. N. 图西理工大学）；Islamic Azad University（伊斯兰阿扎德大学）；University of La Rioja（拉里奥哈大学）；Deakin University（迪肯大学）；Macquarie University（麦考瑞大学）；Harvard University（哈佛大学）；University of Leicester（莱斯特大学）；Universidad de Granada（格拉纳达大学）；University of Cambridge（剑桥大学）
Schizophrenia (SZ) is a mental disorder whereby due to the secretion of specific chemicals in the brain, the function of some brain regions is out of balance, leading to the lack of coordination between thoughts, actions, and emotions. This study provides various intelligent deep learning (DL)-based methods for automated SZ diagnosis via electroencephalography (EEG) signals. The obtained results are compared with those of conventional intelligent methods. To implement the proposed methods, the dataset of the Institute of Psychiatry and Neurology in Warsaw, Poland, has been used. First, EEG sig…
EEG-Based Inter-Patient Epileptic Seizure Detection Combining Domain Adversarial Training with CNN-BiLSTM Network
Graduate School of Advanced Science and Engineering, Hiroshima University（Hiroshima大学先进科学与工程研究生院）；Department of Pediatric Neurology, Okayama University Hospital（Okayama大学医院儿科神经科）
