热激光-组织相互作用过程中的组织光学特性识别：一种基于集合卡尔曼滤波的方法
Identification of Tissue Optical Properties During Thermal Laser-Tissue Interactions: An Ensemble Kalman Filter-Based Approach
AI总结：
本研究提出基于集合卡尔曼滤波的计算框架，通过组织热响应观测估计激光照射下的组织光学等特性，可跟踪时变参数，适用于临床场景。
摘要：
本文提出了一种计算框架，用于估计支配激光照射组织热响应的物理特性。我们特别关注吸收系数和散射系数这两个量，它们描述了组织对光的光学吸收，掌握这些参数对正确规划医疗激光治疗至关重要。为执行估计，我们采用了集合卡尔曼滤波（Ensemble Kalman Filter，EnKF）的实现方案，这是一种用于数据同化的贝叶斯滤波算法。与现有方法不同，本研究基于组织对激光照射的热响应观测来估计组织光学特性。该方法有望在临床环境中直接实施，因为它仅需简单的热传感器，例如微型红外相机。由于组织的光学特性在激光照射期间可能发生变化，我们采用了一种能够跟踪时变参数的EnKF变体。通过模拟实验研究，我们证明了所提技术能够识别组织光学特性并跟踪其在激光照射期间的动态变化，同时还能跟踪表面下方位置的组织温度变化。我们进一步证明了该框架能够估计额外的未知组织特性（即体积热容和热导率）以及目标光学特性。
英文摘要：
In this paper, we propose a computational framework to estimate the physical properties that govern the thermal response of laser-irradiated tissue. We focus in particular on two quantities, the absorption and scattering coefficients, which describe the optical absorption of light in the tissue and whose knowledge is vital to correctly plan medical laser treatments. To perform the estimation, we utilize an implementation of the Ensemble Kalman Filter (EnKF), a type of Bayesian filtering algorithm for data assimilation. Unlike prior approaches, in this work we estimate the tissue optical properties based on observations of the tissue thermal response to laser irradiation. This method has the potential for straightforward implementation in a clinical setup, as it would only require a simple thermal sensor, e.g., a miniaturized infrared camera. Because the optical properties of tissue can undergo shifts during laser exposure, we employ a variant of EnKF capable of tracking time-varying parameters. Through simulated experimental studies, we demonstrate the ability of the proposed technique to identify the tissue optical properties and track their dynamic changes during laser exposure, while simultaneously tracking changes in the tissue temperature at locations beneath the surface. We further demonstrate the framework's capability in estimating additional unknown tissue properties (i.e., the volumetric heat capacity and thermal conductivity) along with the optical properties of interest.
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