为什么以及如何冠状病毒已经演变为独特的传染性，独特成功的稳定疫苗
Why and How Coronavirus Has Evolved to Be Uniquely Contagious, with Uniquely Successful Stable Vaccines
摘要：
刺突蛋白由1200个氨基酸组成，分为两个几乎相等的部分，S1和S2。在这里，我们回顾相变理论，实施定量的热力学标度。该理论解释了冠状病毒极高传染性的演变，这是由在S1中数百个中确定的从CoV2003到CoV2019的一些突变引起的。该理论先前预测了基于刺突的疫苗的空前成功。在这里，我们分析了麦克莱伦等人令人印象深刻的成功，2020年，将他们最初的S2P疫苗稳定为Hexapro。Hexapro将S2P的两个脯氨酸突变，2017，扩展到S2中的六个组合脯氨酸突变。他们的四个新突变是在其详细的基于结构的背景下调查100种可能性的结果。我们的分析仅基于稀疏的公开数据，表明新的脯氨酸突变可以将Hexapro组合提高到Octapro或更高。
英文摘要：
Spike proteins, 1200 amino acids, are divided into two nearly equal parts, S1 and S2. We review here phase transition theory, implemented quantitatively by thermodynamic scaling. The theory explains the evolution of Coronavirus extremely high contagiousness caused by a few mutations from CoV2003 to CoV2019 identified among hundreds in S1. The theory previously predicted the unprecedented success of spike-based vaccines. Here we analyze impressive successes by McClellan et al., 2020, in stabilizing their original S2P vaccine to Hexapro. Hexapro has expanded the two proline mutations of S2P, 2017, to six combined proline mutations in S2. Their four new mutations are the result of surveying 100 possibilities in their detailed structure-based context Our analysis, based on only sparse publicly available data, suggests new proline mutations could improve the Hexapro combination to Octapro or beyond.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
