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arXiv 2106.04285stat.AP
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基于回归校正和模拟外推的随机测量误差的敏感性分析

Sensitivity analysis for random measurement error using regression calibration and simulation-extrapolation

Linda Nab, Rolf H. H. Groenwold

摘要:

在没有验证数据的情况下,可通过回归校准和模拟外推法对测量误差进行敏感性分析。没有为此目的进行比较。在多变量模型中进行了模拟研究,比较了回归校准和模拟外推的性能。根据偏倚、均方误差(MSE)和置信区间覆盖率、易错测量的范围可靠性(0.2-0.9)、样本量(125- 1,000)、重复次数(2-10)和R平方(0.03-0.75)评价了两种方法的性能。假设没有关于无误差测量的验证数据,而正确估计了测量误差方差。在各种情况下,回归校准无偏,而模拟外推有偏:中位偏倚分别为1.4%(四分位距(IQR):0.8;2%)和-12.8%(IQR:-13.2;-11.0%)。观察到模拟外推(中位MSE:0.005,IQR:0.004;0.006)与回归校准(中位MSE:0.006,IQR:0.004;0.007)相比,效率略有提高。回归校准的置信区间覆盖率为95%的标称水平,模拟外推的置信区间覆盖率小于95%(中位覆盖率:92%,IQR:85;94%)。在没有验证数据的情况下,建议使用回归校准进行测量误差的敏感性分析。

英文摘要:

Sensitivity analysis for measurement error can be applied in the absence of validation data by means of regression calibration and simulation-extrapolation. These have not been compared for this purpose. A simulation study was conducted comparing the performance of regression calibration and simulation-extrapolation in a multivariable model. The performance of the two methods was evaluated in terms of bias, mean squared error (MSE) and confidence interval coverage, for ranging reliability of the error-prone measurement (0.2-0.9), sample size (125-1,000), number of replicates (2-10), and R-squared (0.03-0.75). It was assumed that no validation data were available about the error-free measures, while measurement error variance was correctly estimated. In various scenarios, regression calibration was unbiased while simulation-extrapolation was biased: median bias was 1.4% (interquartile range (IQR): 0.8;2%), and -12.8% (IQR: -13.2;-11.0%), respectively. A small gain in efficiency was observed for simulation-extrapolation (median MSE: 0.005, IQR: 0.004;0.006) versus regression calibration (median MSE: 0.006, IQR: 0.004;0.007). Confidence interval coverage was at the nominal level of 95% for regression calibration, and smaller than 95% for simulation-extrapolation (median coverage: 92%, IQR: 85;94%). In the absence of validation data, the use of regression calibration is recommended for sensitivity analysis for measurement error.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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