金纳米坚果作为光热应用的杰出纳米加热器
Gold nanodoughnut as an outstanding nanoheater for photothermal applications
摘要：
光诱导热疗是一种癌症治疗技术，其通过等离子体纳米颗粒产生的热量诱导癌细胞死亡。虽然以前的研究表明，某些纳米粒子在某些条件下可以有效地杀死癌细胞，但仍然有必要（或需要）提高其加热效率。在这项工作中，我们进行了详细的热等离子体研究，将迄今为止最有效的纳米颗粒几何形状与甜甜圈形状的纳米颗粒进行了比较，证明后者在实际照明条件下表现出优异的可调光热响应，即，非偏振光此外，我们表明，纳米粒子加热流体环境中，即，纳米颗粒经历布朗旋转的运动强烈地取决于相对于照明源的颗粒取向。我们的结论是，nanodoughnuts的加热性能是突出的，与第二个最好的纳米加热器（nanodisks）的温度增量高35%。此外，纳米坚果对方向的依赖性较弱，因此是光热治疗应用的理想候选者。最后，我们提出了一个设计指南，涵盖了广泛的环形设计，这可以帮助其实验实施。
英文摘要：
Photoinduced hyperthermia is a cancer therapy technique that induces death to cancerous cells via heat generated by plasmonic nanoparticles. While previous studies have shown that some nanoparticles can be effective at killing cancer cells under certain conditions, there is still a necessity (or the need) to improve its heating efficiency. In this work, we perform a detailed thermoplasmonic study comparing the most effective nanoparticle geometries up to now with a doughnut-shaped nanoparticle, demonstrating that the latter exhibits a superior tunable photothermal response in practical illumination conditions, i.e., unpolarized light. Furthermore, we show that nanoparticle heating in fluidic environments, i.e., nanoparticles undergoing Brownian rotations, strongly depends on the particle orientation with respect to the illumination source. We conclude that the heating performance of nanodoughnuts is outstanding, with a temperature increment 35% higher than the second best nanoheater (nanodisks). Furthermore, nanodoughnuts feature a weak dependence on orientation, being therefore, ideal candidates for photothermal therapy applications. Finally, we present a designing guide, covering a wide range of toroid designs, which can help on its experimental implementation.
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