两种流体动力学效应允许具有与电平无关的导纳的强非线性耳蜗响应
Two hydrodynamic effects allow strongly nonlinear cochlear response with level-independent admittance
摘要：
本文讨论了2-D/3-D耳蜗流体动力学在产生基底膜（BM）和压力响应的大的非线性动态范围中的作用，在耳蜗增益和调谐之间的解耦中的作用，以及在峰值区域中的高增益BM响应的动态稳定中的作用。如果考虑到两种流体动力学效应：与聚焦现象相关的压差放大和BM-流体界面处的粘性阻尼，则BM速度和流体压力增益对刺激水平的较大且密切相关的依赖性（Dong和Olson，2013）与外毛细胞（OHC）机制的生理学导向图式一致。分析的2-D WKB方法的预测进行比较的解决方案的3-D有限元模型，显示这些流体动力学现象产生稳定的高增益响应的峰值区域和平滑过渡的模型与不同的有效性的主动机制，模仿耳蜗的非线性响应在很宽的刺激水平范围。这项研究解释了如何有效的反阻尼非线性OHC力可能会产生大BM和压力的动态范围，以及几乎与水平无关的导纳。
英文摘要：
This paper discusses the role of 2-D/3-D cochlear fluid hydrodynamics in the generation of the large nonlinear dynamical range of the basilar membrane (BM) and pressure response, in the decoupling between cochlear gain and tuning, and in the dynamic stabilization of the high-gain BM response in the peak region. The large and closely correlated dependence on stimulus level of the BM velocity and fluid pressure gain (Dong and Olson, 2013), is consistent with a physiologically-oriented schematization of the outer hair cell (OHC) mechanism if two hydrodynamic effects are accounted for: amplification of the differential pressure associated with a focusing phenomenon, and viscous damping at the BM-fluid interface. The predictions of the analytical 2-D WKB approach are compared to solutions of a 3-D finite element model, showing that these hydrodynamic phenomena yield stable high-gain response in the peak region and a smooth transition among models with different effectiveness of the active mechanism, mimicking the cochlear nonlinear response over a wide stimulus level range. This study explains how an effectively anti-damping nonlinear OHC force may yield large BM and pressure dynamical ranges along with an almost level-independent admittance.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
