PET and CT are two modalities widely used in medical image analysis. Accurately detecting and segmenting lymphomas from these two imaging modalities are critical tasks for cancer staging and radiotherapy planning. However, this task is still challenging due to the complexity of PET/CT images, and the computation cost to process 3D data. In this paper, a segmentation method based on belief functions is proposed to segment lymphomas in 3D PET/CT images. The architecture is composed of a feature extraction module and an evidential segmentation (ES) module. The ES module outputs not only segmentation results (binary maps indicating the presence or absence of lymphoma in each voxel) but also uncertainty maps quantifying the classification uncertainty. The whole model is optimized by minimizing Dice and uncertainty loss functions to increase segmentation accuracy. The method was evaluated on a database of 173 patients with diffuse large b-cell lymphoma. Quantitative and qualitative results show that our method outperforms the state-of-the-art methods.
Deep evidential fusion with uncertainty quantification and contextual discounting for multimodal medical image segmentation
Université de technologie de Compiègne（贡比涅技术大学）；CNRS（法国国家科学研究中心）；Université de Rouen Normandie（鲁昂诺曼底大学）；Centre Henri Becquerel（亨利·贝克勒尔中心）；Institut universitaire de France（法国大学研究院）
There has been growing research interest in using deep learning based method to achieve fully automated segmentation of lesion in Positron emission tomography computed tomography(PET CT) scans for the prognosis of various cancers. Recent advances in the medical image segmentation shows the nnUNET is feasible for diverse tasks. However, lesion segmentation in the PET images is not straightforward, because lesion and physiological uptake has similar distribution patterns. The Distinction of them requires extra structural information in the CT images. The present paper introduces a nnUNet based m…
EviPrompt: A Training-Free Evidential Prompt Generation Method for Segment Anything Model in Medical Images
Beijing University of Posts and Telecommunications（北京邮电大学）；National Institute of Health Data Science, Peking University（北京大学健康数据科学研究所）；The Chinese University of Hong Kong（香港中文大学）
Shanghai AI Lab（上海人工智能实验室）；Shanghai Jiao Tong University（上海交通大学）；University of Surrey（萨里大学）；University of Electronic Science and Technology of China（电子科技大学）；Tongji University（同济大学）
Tumor lesion segmentation is one of the most important tasks in medical image analysis. In clinical practice, Fluorodeoxyglucose Positron-Emission Tomography~(FDG-PET) is a widely used technique to identify and quantify metabolically active tumors. However, since FDG-PET scans only provide metabolic information, healthy tissue or benign disease with irregular glucose consumption may be mistaken for cancer. To handle this challenge, PET is commonly combined with Computed Tomography~(CT), with the CT used to obtain the anatomic structure of the patient. The combination of PET-based metabolic and…
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院同济医院）；Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions（深港脑科学创新研究院——深圳基础研究机构）；United Imaging Research Institute of Innovative Medical Equipment（联影创新医疗装备研究院）；Shenzhen Bay Laboratory（深圳湾实验室）
Achieving accurate and automated tumor segmentation plays an important role in both clinical practice and radiomics research. Segmentation in medicine is now often performed manually by experts, which is a laborious, expensive and error-prone task. Manual annotation relies heavily on the experience and knowledge of these experts. In addition, there is much intra- and interobserver variation. Therefore, it is of great significance to develop a method that can automatically segment tumor target regions. In this paper, we propose a deep learning segmentation method based on multimodal positron em…
3D Lymphoma Segmentation on PET/CT Images via Multi-Scale Information Fusion with Cross-Attention
Zhengzhou University of Light Industry（郑州轻工业大学）；Peking University Institute of Hematology（北京大学血液病研究所）；Kennesaw State University（肯尼索州立大学）；Michigan Technological University（密歇根理工大学）
VRVis Zentrum für Virtual Reality und Visualisierung Forschungs-GmbH（VRVis虚拟现实与可视化研究有限公司）；Center for Medical Physics and Biomedical Engineering, Medical University of Vienna（维也纳医科大学医学物理与生物医学工程中心）；Center for Nuclear Medicine, Clinical Center of Serbia（塞尔维亚临床中心核医学中心）
Tumor segmentation in multimodal medical images has seen a growing trend towards deep learning based methods. Typically, studies dealing with this topic fuse multimodal image data to improve the tumor segmentation contour for a single imaging modality. However, they do not take into account that tumor characteristics are emphasized differently by each modality, which affects the tumor delineation. Thus, the tumor segmentation is modality- and task-dependent. This is especially the case for soft tissue sarcomas, where, due to necrotic tumor tissue, the segmentation differs vastly. Closing this …
HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland（瑞士西部应用科学与艺术大学瓦莱州分校）；Centre Hospitalier Universitaire Vaudois (CHUV)（沃州大学中心医院）；Centre Hospitalier Universitaire de Poitiers (CHUP)（普瓦捷大学中心医院）；Univ Brest（布雷斯特大学）；INSERM（法国国家健康与医学研究院）；LaTIM（医学信息处理实验室）；Cleveland Clinic Foundation（克利夫兰医学中心基金会）；University of Sherbrooke（舍布鲁克大学）
This paper presents an overview of the second edition of the HEad and neCK TumOR (HECKTOR) challenge, organized as a satellite event of the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) 2021. The challenge is composed of three tasks related to the automatic analysis of PET/CT images for patients with Head and Neck cancer (H&N), focusing on the oropharynx region. Task 1 is the automatic segmentation of H&N primary Gross Tumor Volume (GTVt) in FDG-PET/CT images. Task 2 is the automatic prediction of Progression Free Survival (PFS) from the s…
Multimodal Interactive Lung Lesion Segmentation: A Framework for Annotating PET/CT Images based on Physiological and Anatomical Cues
HIDSS4Health - Helmholtz Information and Data Science School for Health（亥姆霍兹信息与健康数据科学学院（HIDSS4Health））；Institute for AI in Medicine (IKIM), University Hospital Essen（埃森大学医院医学人工智能研究所（IKIM））
LaTIM, INSERM, UMR 1101, University Brest（拉蒂姆研究所、法国国家健康与医学研究院、布雷斯特大学）
Development of robust and accurate fully automated methods for medical image segmentation is crucial in clinical practice and radiomics studies. In this work, we contributed an automated approach for Head and Neck (H&N) primary tumor segmentation in combined positron emission tomography / computed tomography (PET/CT) images in the context of the MICCAI 2020 Head and Neck Tumor segmentation challenge (HECKTOR). Our model was designed on the U-Net architecture with residual layers and supplemented with Squeeze-and-Excitation Normalization. The described method achieved competitive results in cro…
The Positron Emission Tomography (PET) scan image requires expertise in the segmentation where clustering algorithm plays an important role in the automation process. The algorithm optimization is concluded based on the performance, quality and number of clusters extracted. This paper is proposed to study the commonly used K Means clustering algorithm and to discuss a brief list of toolboxes for reproducing and extending works presented in medical image analysis. This work is compiled using AForge .NET framework in windows environment and MATrix LABoratory (MATLAB 7.0.1)
RADIANT-PET: Reasoning-Augmented PET/CT Lesion Segmentation with Large Language Models and Reinforcement Learning
Division of Hematology, The Ohio State University Comprehensive Cancer Center（血液科，俄亥俄州立大学综合癌症中心）；Department of Radiology, Mahidol University（医学放射科，玛希多大学）；Department of Radiology, Mettapracharak Hospital（医学放射科，Mettapracharak医院）；Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center（放射肿瘤科，俄亥俄州立大学综合癌症中心）
Sathyabama University（萨蒂亚巴马大学）；Narasu’s Sarathy Institute of Technology（纳拉苏萨拉蒂技术学院）
Medical image segmentation is referred to the segmentation of known anatomic structures from different medical images. Normally, the medical data researches are more complicated and an exclusive structures. This computer aided diagnosis is used for assisting doctors in evaluating medical imagery or in recognizing abnormal findings in a medical image. To integrate the specialized knowledge for medical data processing is helpful to form a real useful healthcare decision making system. This paper studies the different symmetry based distances applied in clustering algorithms and analyzes symmetry…
AdaMSS: Adaptive Multi-Modality Segmentation-to-Survival Learning for Survival Outcome Prediction from PET/CT Images
The University of Sydney（悉尼大学）；Shanghai Jiao Tong University（上海交通大学）；Fudan University Shanghai Cancer Center（复旦大学附属肿瘤医院）；Fudan University（复旦大学）；Royal Prince Alfred Hospital（皇家阿尔弗雷德亲王医院）
Institut universitaire de France（法国大学研究院）；CHB Hospital（CHB医院）；University of Rouen Normandy（鲁昂诺曼底大学）
Lymphoma detection and segmentation from whole-body Positron Emission Tomography/Computed Tomography (PET/CT) volumes are crucial for surgical indication and radiotherapy. Designing automatic segmentation methods capable of effectively exploiting the information from PET and CT as well as resolving their uncertainty remain a challenge. In this paper, we propose an lymphoma segmentation model using an UNet with an evidential PET/CT fusion layer. Single-modality volumes are trained separately to get initial segmentation maps and an evidential fusion layer is proposed to fuse the two pieces of ev…
Imperial College London（帝国理工学院）；TECNALIA（TECNALIA（西班牙技术中心））；University of the Basque Country (UPV/EHU)（巴斯克大学）；Royal Brompton Hospital（皇家布朗普顿医院）
Despite recent advances in the accuracy of brain tumor segmentation, the results still suffer from low reliability and robustness. Uncertainty estimation is an efficient solution to this problem, as it provides a measure of confidence in the segmentation results. The current uncertainty estimation methods based on quantile regression, Bayesian neural network, ensemble, and Monte Carlo dropout are limited by their high computational cost and inconsistency. In order to overcome these challenges, Evidential Deep Learning (EDL) was developed in recent work but primarily for natural image classific…
Multi-modal Evidential Fusion Network for Trustworthy PET/CT Tumor Segmentation
Soochow University（苏州大学）；the University of Hong Kong（香港大学）；Southern University of Science and Technology（南方科技大学）；Changshu Institute of Technology（常熟理工学院）；the First Affiliated Hospital of Soochow University（苏州大学附属第一医院）
INSA Rouen Normandie, Univ Rouen Normandie, Université Le Havre Normandie, Normandie Univ, LITIS UR 4108, F-76000 Rouen, France（法国诺曼底 Rouen 大学）；Nuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, France（亨利·贝克勒尔癌症中心核医学部）；Radiotherapy Department, Henri Becquerel Cancer Center, Rouen, France（亨利·贝克勒尔癌症中心放射治疗部）；Siemens Healthineers（西门子医疗）
Uncertainty-Error correlations in Evidential Deep Learning models for biomedical segmentation
Gryphon Center for Artificial Intelligence and Theoretical Sciences, Singapore University of Pennsylvania, Perelman School of Medicine, Department of Radiation Oncology（格雷芬人工智能与理论科学中心，新加坡大学匹兹堡大学，佩尔曼医学学院，放射肿瘤学系）；Georgia Institute of Technology（佐治亚理工学院）；University of Pennsylvania, Perelman School of Medicine, Department of Radiation Oncology（宾夕法尼亚大学，佩尔曼医学学院，放射肿瘤学系）
Efficient Parameter Adaptation for Multi-Modal Medical Image Segmentation and Prognosis
Department of Computer Vision, Mohamed bin Zayed University of Artificial Intelligence（计算机视觉系，Mohamed bin Zayed人工智能大学）；Department of Machine Learning, Mohamed bin Zayed University of Artificial Intelligence（机器学习系，Mohamed bin Zayed人工智能大学）；Michigan State University（密歇根州立大学）；M42 Health（M42健康）
Mutual Evidential Deep Learning for Medical Image Segmentation
Key Laboratory of High Confidence Software Technologies (MOE) School of Computer Science Peking University（高可信软件技术重点实验室（MOE）计算机科学学院，北京大学）；College of Computer and Information Science School of Software Southwest University（计算机与信息科学学院 软件学院 西南大学）；Department of Computer and Information Science University of Macau（计算机与信息科学系 澳门大学）
Sliding Window FastEdit: A Framework for Lesion Annotation in Whole-body PET Images
HIDSS4Health - Helmholtz Information and Data Science School for Health（亥姆霍兹信息与健康数据科学学院）；Institute for AI in Medicine (IKIM), University Hospital Essen（埃森大学医院医学人工智能研究所）
Towards Reliable Medical Image Segmentation by Modeling Evidential Calibrated Uncertainty
National Key Laboratory of Fundamental Science on Synthetic Vision, the College of Computer Science, Sichuan University（国家基础科学合成视觉重点实验室、计算机科学学院、四川大学）；Department of Radiology, West China Hospital, Sichuan University（放射科、西昌医院、四川大学）；Saw Swee Hock School of Public Health, National University of Singapore（Saw Swee Hock 公共卫生学院、新加坡国立大学）；Department of Mathematics, Sichuan University（数学系、四川大学）；Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR)（高性能计算研究所（IHPC）、科学、技术与研究局（A*STAR））；Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore（创新与精准眼健康中心、 Yong Loo Lin 医学院、新加坡国立大学）；Singapore Eye Research Institute, Singapore National Eye Centre（新加坡眼研究所、新加坡国家眼科中心）
University of Sydney（悉尼大学）；Royal Prince Alfred Hospital（阿尔弗雷德王子医院）
The analysis of multi-modality positron emission tomography and computed tomography (PET-CT) images for computer aided diagnosis applications requires combining the sensitivity of PET to detect abnormal regions with anatomical localization from CT. Current methods for PET-CT image analysis either process the modalities separately or fuse information from each modality based on knowledge about the image analysis task. These methods generally do not consider the spatially varying visual characteristics that encode different information across the different modalities, which have different priori…
Uncertainty-informed Mutual Learning for Joint Medical Image Classification and Segmentation
Sichuan University（四川大学）；West China Hospital, Sichuan University（四川大学华西医院）；Institute of High Performance Computing, Agency for Science, Technology and Research（新加坡科技研究局高性能计算研究所）
A Generalist Foundation Model for Total-body PET/CT Enables Diagnostic Reporting and System-wide Metabolic Profiling
Shandong First Medical University & Shandong Academy of Medical Sciences（山东第一医科大学（山东省医学科学院））；Shandong Provincial Hospital, Shandong First Medical University（山东第一医科大学附属省立医院）；Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院附属湖北肿瘤医院）；The Second Affiliated Hospital of Shandong First Medical University（山东第一医科大学第二附属医院）；The first Affiliated Hospital of Shandong First Medical University（山东第一医科大学第一附属医院）
Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesions with different shapes, sizes, and uptake intensity may be distributed in different anatomical contexts throughout the body, and there is also significant uptake in healthy organs. Therefore, building a systemic PET/CT tumor lesion segmentation model is a challenging task. In this paper, we propose a novel step-by-step 3D segmentation method to address this problem. We achieved Dice score of 0.92, false positive volume of 0.89 and false negative volume …
University of Sydney（悉尼大学）；Royal Prince Alfred Hospital（皇家阿尔弗雷德王子医院）
Sequential whole-body 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) scans are regarded as the imaging modality of choice for the assessment of treatment response in the lymphomas because they detect treatment response when there may not be changes on anatomical imaging. Any computerized analysis of lymphomas in whole-body PET requires automatic segmentation of the studies so that sites of disease can be quantitatively monitored over time. State-of-the-art PET image segmentation methods are based on convolutional neural networks (CNNs) given their ability to leverage annotated…
Nanjing University of Science and Technology（南京理工大学）；Nanjing University（南京大学）
Automatic segmentation of head and neck tumors plays an important role in radiomics analysis. In this short paper, we propose an automatic segmentation method for head and neck tumors from PET and CT images based on the combination of convolutional neural networks (CNNs) and hybrid active contours. Specifically, we first introduce a multi-channel 3D U-Net to segment the tumor with the concatenated PET and CT images. Then, we estimate the segmentation uncertainty by model ensembles and define a segmentation quality score to select the cases with high uncertainties. Finally, we develop a hybrid …
Head and neck tumor segmentation challenge (HECKTOR) 2022 offers a platform for researchers to compare their solutions to segmentation of tumors and lymph nodes from 3D CT and PET images. In this work, we describe our solution to HECKTOR 2022 segmentation task. We re-sample all images to a common resolution, crop around head and neck region, and train SegResNet semantic segmentation network from MONAI. We use 5-fold cross validation to select best model checkpoints. The final submission is an ensemble of 15 models from 3 runs. Our solution (team name NVAUTO) achieves the 1st place on the HECKT…
TMF-RSE: Tri-Modal Fusion with Regional Semantics and Evidential Uncertainty for Lung Severity Scoring
Institute of Applied Sciences and Intelligent Systems (ISASI), CNR（应用科学与智能系统研究所（ISASI），CNR）；Department of Computer Science and Artificial Intelligence, University of the Basque Country (UPV/EHU)（巴斯克国家大学计算机科学与人工智能系）；University of Salento（萨莱nton大学）
PAII Inc.（PAII公司）；Chang Gung Memorial Hospital（长庚纪念医院）；Ping An Technology（平安科技）
Gross tumor volume (GTV) segmentation is a critical step in esophageal cancer radiotherapy treatment planning. Inconsistencies across oncologists and prohibitive labor costs motivate automated approaches for this task. However, leading approaches are only applied to radiotherapy computed tomography (RTCT) images taken prior to treatment. This limits the performance as RTCT suffers from low contrast between the esophagus, tumor, and surrounding tissues. In this paper, we aim to exploit both RTCT and positron emission tomography (PET) imaging modalities to facilitate more accurate GTV segmentati…
Multimodal positron emission tomography-computed tomography (PET-CT) is used routinely in the assessment of cancer. PET-CT combines the high sensitivity for tumor detection with PET and anatomical information from CT. Tumor segmentation is a critical element of PET-CT but at present, there is not an accurate automated segmentation method. Segmentation tends to be done manually by different imaging experts and it is labor-intensive and prone to errors and inconsistency. Previous automated segmentation methods largely focused on fusing information that is extracted separately from the PET and CT…
Recent progress in automated PET/CT lesion segmentation using deep learning methods has demonstrated the feasibility of this task. However, tumor lesion detection and segmentation in whole-body PET/CT is still a chal-lenging task. To promote research on machine learning-based automated tumor lesion segmentation on whole-body FDG-PET/CT data, Automated Lesion Segmentation in Whole-Body FDG-PET/CT (autoPET) challenge is held, and a large, publicly available training dataset is provided. In this report, we present our solution to the autoPET challenge. We employ multi-modal residual U-Net with de…
Autopet III challenge: Incorporating anatomical knowledge into nnUNet for lesion segmentation in PET/CT
Institute for AI in Medicine (IKIM)（医学人工智能研究所）；University Hospital Essen (AöR)（埃森大学医院）；Department of Nuclear Medicine（核医学科）；Cancer Research Center Cologne Essen (CCCE)（科隆埃森癌症研究中心）；West German Cancer Center Essen University Hospital Essen (AöR)（埃森大学医院西德癌症中心）；TU Dortmund（多特蒙德工业大学）；German Cancer Consortium (DKTK, Partner site Essen)（德国癌症联盟（埃森合作站点））
本研究针对 PET/CT 病变分割，提出基于示踪剂分类和集成 nnUNet 的方法，融合解剖标签，在 autoPET III 挑战中取得高 Dice 分数。
Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesion with different shapes, sizes, and uptake intensity may be distributed in different anatomical contexts throughout the body, and there is also significant uptake in healthy organs. Therefore, building a systemic PET/CT tumor lesion segmentation model is a challenging task. In this paper, we propose a novel training strategy to build deep learning models capable of systemic tumor segmentation. Our method is validated on the training set of the AutoPET 202…
Self is the Best Learner: CT-free Ultra-Low-Dose PET Organ Segmentation via Collaborating Denoising and Segmentation Learning
School of Biomedical Engineering, Southern Medical University（生物医学工程学院，南方医科大学）；School of Biomedical Engineering, Shanghai Jiao Tong University（生物医学工程学院，上海交通大学）；Nanfang PET Center, Nanfang Hospital Southern Medical University（南芳PET中心，南方医科大学南芳医院）；Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University（广东省医学图像处理重点实验室，南方医科大学）；Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University（广东省医学影像与诊断技术工程实验室，南方医科大学）；Pazhou Lab（琶洲实验室）
Background: A crucial initial processing step for quantitative PET/CT analysis is the segmentation of tumor lesions enabling accurate feature ex-traction, tumor characterization, oncologic staging, and image-based therapy response assessment. Manual lesion segmentation is however associated with enormous effort and cost and is thus infeasible in clinical routine. Goal: The goal of this study was to report the performance of a deep neural network designed to automatically segment regions suspected of cancer in whole-body 18F-FDG PET/CT images in the context of the AutoPET challenge. Method: A c…
H2ASeg: Hierarchical Adaptive Interaction and Weighting Network for Tumor Segmentation in PET/CT Images
School of Science, Harbin Institute of Technology (Shenzhen)（哈尔滨工业大学（深圳）理学院）；School of Computer Science and Technology, Harbin Institute of Technology (Shenzhen)（哈尔滨工业大学（深圳）计算机科学与技术学院）
