外部苍白球:局部思考,全球行动
The external pallidum: think locally, act globally
摘要:
由于对基底神经节苍白球(GPe)的细胞和回路的认识不足,几十年来一直没有得到充分的认识。分子工具的出现引发了对GPe兴趣的复苏。在这里,我们回顾了最近的一系列出版物,揭示了GPe内的分子景观和细胞组成的复杂性。这些发现揭示了GPe神经元显示出许多不符合基底神经节传统观点的回路特征。与其在大脑中广泛的相互连接相一致,新出现的证据表明GPe在运动和非运动功能中起着多方面的作用。总之,最近的数据突出了GPe内的细胞和功能多样性,并提示基底神经节的计算规则的新建议。
英文摘要:
The globus pallidus (GPe) of the basal ganglia has been underappreciated for decades due to poor understanding of its cells and circuits. The advent of molecular tools has sparked a resurgence in interest in the GPe. Here, we review a recent flurry of publications that has unveiled the complexity of the molecular landscape and cellular composition within the GPe. These discoveries have revealed that GPe neurons display a number of circuit features that do not conform to the traditional views of the basal ganglia. Consistent with its broad interconnectivity across the brain, emerging evidence suggests that the GPe plays multifaceted roles in both motor and non-motor functions. Altogether, recent data highlight cellular and functional diversity within the GPe and prompt new proposals for computational rules of the basal ganglia.
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