arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2104.09269cond-mat.softphysics.app-phphysics.flu-dyn
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反馈控制微泡generator每秒产生一百万个单分散气泡

Feedback-controlled microbubble generator producing one million monodisperse bubbles per second

Benjamin van Elburg, Gonzalo Collado Lara, Gert-Wim Bruggert, Tim Segers, Michel Versluis, Guillaume Lajoinie

摘要:

单分散脂质涂层微泡是一种很有前途的途径,以释放超声造影剂的全部潜力,用于医疗诊断和治疗。在这里,我们提出了一个独立的芯片实验室仪器,允许微泡形成高单分散性,高生产率。在完全控制输出尺寸分布的情况下保持微流体装置的长期稳定、受控和安全操作的关键是基于光学透射的测量技术,其提供关于生产速率和气泡尺寸的实时信息。我们将数据馈送到反馈回路中,并证明该系统可以控制片上气泡半径(2.5至20 $μ$ m)和生产速率高达$10^6$气泡/s。新鲜形成的磷脂包被的气泡在其形成后稳定到比其初始芯片上气泡尺寸小约两倍的尺寸,而不损失单分散性。反馈控制技术允许对试剂的尺寸分布进行完全控制,并且可以帮助开发由非专业终端用户操作的微流体平台。

英文摘要:

Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present a stand-alone lab-on-a-chip instrument that allows microbubbles to be formed with high monodispersity at high production rates. Key to maintaining a long-term stable, controlled, and safe operation of the microfluidic device with full control over the output size distribution is an optical transmission based measurement technique that provides real-time information on production rate and bubble size. We feed the data into a feedback loop and demonstrate that this system can control the on-chip bubble radius (2.5 to 20 $μ$m) and the production rate up to $10^6$ bubbles/s. The freshly formed phospholipid-coated bubbles stabilize after their formation to a size approximately two times smaller than their initial on-chip bubble size without loss of monodispersity. The feedback control technique allows for full control over the size distribution of the agent and can aid the development of microfluidic platforms operated by non-specialist end users.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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