正弦和噪声输入下工作记忆群体模型的活动稳定性
Activity stabilization in a population model of working memory by sinusoidal and noisy inputs
摘要：
根据工作记忆的机制理论，信息是通过皮层神经网络的持续放电活动而被保存的。然而，这种活动是如何与WM任务中观察到的振荡轮廓的变化仍然是一个悬而未决的问题。我们探讨了输入的伽玛波段振荡和噪声的联合影响的几个射击率模型的WM的动力学。所考虑的模型有一个亚稳态的活动制度，即他们表现出持久的瞬态刺激后放电率升高。我们从单个兴奋-抑制电路开始，并证明γ波段或噪声输入都可以稳定活动状态，从而支持WM保留。然后，我们考虑一个系统的两个电路与兴奋性相互耦合。我们发现，快速耦合允许更好的稳定，由共同的噪声相比，独立的噪声和更强的放大这种效果，由同相伽马输入相比，反相输入。最后，我们考虑一个多电路系统，由两个集群，每个集群包含一组电路接收一个共同的噪声输入和一组电路接收独立的噪声。每个集群都与自己的本地伽马发生器相关联，因此其所有电路都以相同的相位接收伽马波段输入。我们发现，伽马波段输入差分稳定的活动相比，“独立噪声”组的“共同噪声”组。如果集群间连接速度很快，则当伽马波段输入以相同相位而不是反相位传递到集群时，这种效应更加明显。假设共同噪声来自大规模分布式WM表示，我们的研究结果表明，本地伽马振荡可以稳定该表示的相应部分的活动，快速远程连接和同步伽马振荡的效果更强。
英文摘要：
According to mechanistic theories of working memory (WM), information is retained as persistent spiking activity of cortical neural networks. Yet, how this activity is related to changes in the oscillatory profile observed during WM tasks remains an open issue. We explore joint effects of input gamma-band oscillations and noise on the dynamics of several firing rate models of WM. The considered models have a metastable active regime, i.e. they demonstrate long-lasting transient post-stimulus firing rate elevation. We start from a single excitatory-inhibitory circuit and demonstrate that either gamma-band or noise input could stabilize the active regime, thus supporting WM retention. We then consider a system of two circuits with excitatory intercoupling. We find that fast coupling allows for better stabilization by common noise compared to independent noise and stronger amplification of this effect by in-phase gamma inputs compared to anti-phase inputs. Finally, we consider a multi-circuit system comprised of two clusters, each containing a group of circuits receiving a common noise input and a group of circuits receiving independent noise. Each cluster is associated with its own local gamma generator, so all its circuits receive gamma-band input in the same phase. We find that gamma-band input differentially stabilizes the activity of the "common-noise" groups compared to the "independent-noise" groups. If the inter-cluster connections are fast, this effect is more pronounced when the gamma-band input is delivered to the clusters in the same phase rather than in the anti-phase. Assuming that the common noise comes from a large-scale distributed WM representation, our results demonstrate that local gamma oscillations can stabilize the activity of the corresponding parts of this representation, with stronger effect for fast long-range connections and synchronized gamma oscillations.
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