自组装氧化还原丝形成能量转换细胞膜的2D电网
Self-assembling redox-wires form the 2D power grid of energy converting cell membranes
摘要：
光合作用的光驱动反应以及线粒体的能量供应都在含有高比例氧化还原脂质的专门膜内。蛋白质的迁移和氧化还原脂质的扩散被认为是沿着这种细胞膜的平面内电荷转移机制。使用膜上的芯片设置，我们表明，氧化还原活性模型膜可以进行和维持惊人的高（mA）电流与典型的半导体电阻率。我们的数据表明，细胞壁内的电荷转移托管电子转移链驱动的自组装分子氧化还原线，有效地耦合氧化还原蛋白质的同时在膜内的平面跳跃的电子和质子。这完全改变了我们对脂质膜作用的理解，具有广泛的影响，表明例如导电膜可能是进化复杂的生命氧化还原机制的前体，并且电化学膜劣化可能在线粒体衰老中起重要作用。此外，这些自组装有机2D导体提供了技术上可利用的特征，允许设计自组装和自适应生物电子器件。
英文摘要：
The light-driven reactions of photosynthesis, as well as the mitochondrial power supply, are hosted within specialized membranes containing a high fraction of redoxactive lipids. Protein mobility and diffusion of redox lipids is believed to be the in plane charge transfer mechanism along such cell membranes. Using a membrane-on-a-chip setup, we show that redox-active model membranes can conduct and sustain surprisingly high (mA) currents with a specific resistivity typical for semiconductors. Our data suggest that charge transfer within cell walls hosting electron-transferchains is driven by self-assembling molecular redox-wires that effectively couple redox-proteins by a simultaneous electron and proton in plane hopping within a membrane. This completely alters our understanding of the role of lipid membranes with wide-range implications suggesting e.g. that conducting membranes may be the precursor for evolving complex redox-machineries of life, and electrochemical membrane deterioration may play an important role in mitochondrial aging. Further, these self-assembling organic 2D-conductors offer technologically exploitable features allowing for designing self-assembling and adaptive bio-electronics.
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