相干成像中分辨率增强的OCT和信息容量和分辨率的扩展框架
Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging
摘要：
光学显微镜中的空间分辨率传统上被视为光学系统的固定参数。在这里，我们提出了一种方法，以提高横向分辨率光束扫描光学相干断层扫描（OCT）超过其无像差的分辨率限制，没有任何修改的光学系统。基于信息容量不变性原理，分辨率增强（RE）-OCT通过相干平均和简单的计算带宽扩展过程利用有效的噪声抑制来导航分辨率和信噪比（SNR）之间的信息交换。我们证明了相对于无像差极限的1.5倍的分辨率增强，同时在硅胶体模中保持相当的SNR。我们表明，RE-OCT可以显着增强胶原蛋白凝胶和离体小鼠大脑中的精细显微结构特征的可视化。除了RE-OCT，我们在空间频率域的分析导致了一个扩展的框架，信息容量和分辨率的相干成像，有助于新的影响相干成像的理论。RE-OCT可以很容易地在全球大多数OCT系统上实现，立即解锁超出其当前成像能力的信息，因此在OCT使用的众多领域（包括基础科学和转化医学）具有广泛影响的潜力。
英文摘要：
Spatial resolution in optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting efficient noise suppression via coherent averaging and a simple computational bandwidth expansion procedure. We demonstrate a resolution enhancement of 1.5 times relative to the aberration-free limit while maintaining comparable SNR in silicone phantom. We show that RE-OCT can significantly enhance the visualization of fine microstructural features in collagen gel and ex vivo mouse brain. Beyond RE-OCT, our analysis in the spatial-frequency domain leads to an expanded framework of information capacity and resolution in coherent imaging that contributes new implications to the theory of coherent imaging. RE-OCT can be readily implemented on most OCT systems worldwide, immediately unlocking information that is beyond their current imaging capabilities, and so has the potential for widespread impact in the numerous areas in which OCT is utilized, including the basic sciences and translational medicine.
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