硅羟基磷灰石涂层与VEGF吸附在Ti6Al4V-ELI支架上的协同作用
Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment
摘要：
在体外和体内评价了硅取代羟基磷灰石（SiHA）涂层和血管内皮生长因子（VEGF）修饰的金属大孔支架的成骨和血管生成反应。通过电子束熔融制备Ti6 Al 4V-ELI支架，随后在浸涂方法之后涂覆Ca 10（PO 4）5.6（SiO 4）0.4（OH）1.6。体外研究表明，SiHA刺激MC 3 T3-E1前成骨细胞的增殖，而VEGF的吸附刺激EC 2成熟内皮细胞的增殖。体内研究在骨质疏松绵羊模型中进行，证明只有同时存在两种组分才能导致骨质疏松骨中新组织形成的显著增加。
英文摘要：
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca10(PO4)5.6(SiO4)0.4(OH)1.6 following a dip coating method. In vitro studies demonstrated that SiHA stimulates the proliferation of MC3T3-E1 pre-osteoblastic cells, whereas the adsorption of VEGF stimulates the proliferation of EC2 mature endothelial cells. In vivo studies were carried out in an osteoporotic sheep model, evidencing that only the simultaneous presence of both components led to a significant increase of new tissue formation in osteoporotic bone.
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