整体和局部突触调节决定了稳态可塑性的稳定性
Global and local synaptic regulation determine the stability of homeostatic plasticity
摘要：
神经元通过局部和全局反馈控制来调节信号成分在扩展的树状细胞结构中的分布。这被假设为允许对神经元的电活动进行稳态控制，并且同时使得能够对从其他细胞接收的输入的分布进行归一化。这些机制的性能和鲁棒性知之甚少，并受到非线性，使其分析困难。首先，我们正式证明了在足够的时间尺度分离下，电活动的全局稳态和局部活动依赖性降解可以共存。两个反馈机制的相互作用也通过模拟分析，这揭示了一个双向的影响（稳定和不稳定）的活动依赖性退化的整体神经元的性能。
英文摘要：
Neurons regulate the distribution of signaling components across an extended tree-like cellular structure using both local and global feedback control. This is hypothesized to allow homeostatic control of the electrical activity of a neuron and at the same time enable normalization of distribution of inputs received from other cells. The performance and robustness of these mechanisms are poorly understood, and are subject to nonlinearities, making their analysis difficult. Firstly, we formally show that global homeostasis of electrical activity and local activity-dependent degradation can coexist under sufficient timescale separation. The interplay of the two feedback mechanisms is also analyzed through simulations, which reveal a bidirectional effect (stabilizing and destabilizing) of activity-dependent degradation on the overall neuron performance.
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