ViralFP：病毒融合蛋白的网络服务器
ViralFP: A webserver of viral fusion proteins
摘要：
病毒融合蛋白附着在包膜病毒（包括冠状病毒，登革热，HIV和流感病毒）的膜上，并催化病毒和宿主膜之间的融合，使病毒能够将其遗传物质插入宿主细胞。考虑到这些生物分子的重要性，这项工作提出了一个集中的数据库，其中包含病毒融合蛋白的最相关信息，可通过免费使用的Web服务器访问，通过URL https://viralfp.bio.di.uminho.pt/。该Web应用程序包含几种生物信息学工具，如Clustal序列比对和Weblogo，还包括一种基于机器学习的工具，能够预测融合蛋白质序列内融合肽（插入宿主细胞膜的融合蛋白组分）的位置。鉴于这些蛋白质在病毒感染中的关键作用，它们作为我们免疫系统天然靶点的重要性以及它们作为治疗靶点的潜力，这个网络应用程序旨在培养我们对抗致病病毒的能力。
英文摘要：
Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell. Given the importance of these biomolecules, this work presents a centralized database containing the most relevant information on viral fusion proteins, available through a free-to-use web server accessible through the URL https://viralfp.bio.di.uminho.pt/. This web application contains several bioinformatic tools, such as Clustal sequence alignment and Weblogo, including as well a machine learning-based tool capable of predicting the location of fusion peptides (the component of fusion proteins that inserts into the host's cell membrane) within the fusion protein sequence. Given the crucial role of these proteins in viral infection, their importance as natural targets of our immune system and their potential as therapeutic targets, this web application aims to foster our ability to fight pathogenic viruses.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
