In the context of the current global pandemic and the limitations of the RT-PCR test, we propose a novel deep learning architecture, DFCN (Denoising Fully Connected Network). Since medical facilities around the world differ enormously in what laboratory tests or chest imaging may be available, DFCN is designed to be robust to missing input data. An ablation study extensively evaluates the performance benefits of the DFCN as well as its robustness to missing inputs. Data from 1088 patients with confirmed RT-PCR results are obtained from two independent medical facilities. The data includes results from 27 laboratory tests and a chest x-ray scored by a deep learning model. Training and test datasets are taken from different medical facilities. Data is made publicly available. The performance of DFCN in predicting the RT-PCR result is compared with 3 related architectures as well as a Random Forest baseline. All models are trained with varying levels of masked input data to encourage robustness to missing inputs. Missing data is simulated at test time by masking inputs randomly. DFCN outperforms all other models with statistical significance using random subsets of input data with 2-27 available inputs. When all 28 inputs are available DFCN obtains an AUC of 0.924, higher than any other model. Furthermore, with clinically meaningful subsets of parameters consisting of just 6 and 7 inputs respectively, DFCN achieves higher AUCs than any other model, with values of 0.909 and 0.919.
Diagnosis of COVID-19 at point of care is vital to the containment of the global pandemic. Point of care ultrasound (POCUS) provides rapid imagery of lungs to detect COVID-19 in patients in a repeatable and cost effective way. Previous work has used public datasets of POCUS videos to train an AI model for diagnosis that obtains high sensitivity. Due to the high stakes application we propose the use of robust and explainable techniques. We demonstrate experimentally that robust models have more stable predictions and offer improved interpretability. A framework of contrastive explanations based…
Fudan University（复旦大学）；Shanghai AI Laboratory（上海人工智能实验室）；Children’s Hospital of Fudan University（复旦大学附属儿科医院）；National Children’s Medical Center（国家儿童医学中心）
This paper presents our solution for the 2nd COVID-19 Competition, occurring in the framework of the AIMIA Workshop at the European Conference on Computer Vision (ECCV 2022). In our approach, we employ the winning solution last year which uses a strong 3D Contrastive Mixup Classifcation network (CMC v1) as the baseline method, composed of contrastive representation learning and mixup classification. In this paper, we propose CMC v2 by introducing natural video priors to COVID-19 diagnosis. Specifcally, we adapt a pre-trained (on video dataset) video transformer backbone to COVID-19 detection. …
Towards Automated COVID-19 Presence and Severity Classification
Faculty of Applied Computer Science, University of Augsburg（奥格斯堡大学应用计算机科学学院）；Institute for Digital Medicine, University Hospital Augsburg（奥格斯堡大学医院数字医学研究所）
University of South Florida（南佛罗里达大学）；University of California, San Francisco（加州大学旧金山分校）
Identifying who is infected with the Covid-19 virus is critical for controlling its spread. X-ray machines are widely available worldwide and can quickly provide images that can be used for diagnosis. A number of recent studies claim it may be possible to build highly accurate models, using deep learning, to detect Covid-19 from chest X-ray images. This paper explores the robustness and generalization ability of convolutional neural network models in diagnosing Covid-19 disease from frontal-view (AP/PA), raw chest X-ray images that were lung field cropped. Some concerning observations are made…
Coronavirus disease 2019 (COVID-19) is a Public Health Emergency of International Concern infecting more than 40 million people across 188 countries and territories. Chest computed tomography (CT) imaging technique benefits from its high diagnostic accuracy and robustness, it has become an indispensable way for COVID-19 mass testing. Recently, deep learning approaches have become an effective tool for automatic screening of medical images, and it is also being considered for COVID-19 diagnosis. However, the high infection risk involved with COVID-19 leads to relative sparseness of collected la…
Rutgers University（罗格斯大学）；Rutgers New Jersey Medical School（罗格斯新泽西医学院）；Rutgers Cancer Institute of New Jersey（罗格斯新泽西癌症研究所）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特·伍德·约翰逊医学院）
Recently, the outbreak of the novel Coronavirus disease 2019 (COVID-19) pandemic has seriously endangered human health and life. Due to limited availability of test kits, the need for auxiliary diagnostic approach has increased. Recent research has shown radiography of COVID-19 patient, such as CT and X-ray, contains salient information about the COVID-19 virus and could be used as an alternative diagnosis method. Chest X-ray (CXR) due to its faster imaging time, wide availability, low cost and portability gains much attention and becomes very promising. Computational methods with high accurac…
Inception Institute of Artificial Intelligence（起源人工智能研究院）；Indian Institute of Technology, Kanpur（印度理工学院坎普尔分校）
While medical image segmentation is an important task for computer aided diagnosis, the high expertise requirement for pixelwise manual annotations makes it a challenging and time consuming task. Since conventional data augmentations do not fully represent the underlying distribution of the training set, the trained models have varying performance when tested on images captured from different sources. Most prior work on image synthesis for data augmentation ignore the interleaved geometric relationship between different anatomical labels. We propose improvements over previous GAN-based medical…
Purdue University（普渡大学）；Etsy, Inc（Etsy公司）；University at Albany, State University of New York（纽约州立大学奥尔巴尼分校）；University of South Australia（南澳大学）；Sapienza University of Rome（罗马大学）
Hangzhou Dianzi University（杭州电子科技大学）；Communication University of Zhejiang（浙江传媒学院）；University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Shanghai Jiao Tong University（上海交通大学）
Coronavirus disease 2019 (COVID-19) is one of the most destructive pandemic after millennium, forcing the world to tackle a health crisis. Automated lung infections classification using chest X-ray (CXR) images could strengthen diagnostic capability when handling COVID-19. However, classifying COVID-19 from pneumonia cases using CXR image is a difficult task because of shared spatial characteristics, high feature variation and contrast diversity between cases. Moreover, massive data collection is impractical for a newly emerged disease, which limited the performance of data thirsty deep learni…
The recent outbreak of COVID-19 has halted the whole world, bringing a devastating effect on public health, global economy, and educational systems. As the vaccine of the virus is still not available, the most effective way to combat the virus is testing and social distancing. Among all other detection techniques, the Chest X-ray (CXR) based method can be a good solution for its simplicity, rapidity, cost, efficiency, and accessibility. In this paper, we propose CovMUNET, which is a multiple loss deep neural network approach to detect COVID-19 cases from CXR images. Extensive experiments are p…
Coronavirus (COVID-19) has shown an unprecedented global crisis by the detrimental effect on the global economy and health. The number of COVID-19 cases has been rapidly increasing, and there is no sign of stopping. It leads to a severe shortage of test kits and accurate detection models. A recent study demonstrated that the chest X-ray radiography outperformed laboratory testing in COVID-19 detection. Therefore, using chest X-ray radiography analysis can help to screen suspected COVID-19 cases at an early stage. Moreover, the patient data is sensitive, and it must be protected to avoid reveal…
Sun Yat-sen University（中山大学）；Shuguang Hospital, Shanghai University of Traditional Chinese Medicine（上海中医药大学附属曙光医院）；University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
As the COVID-19 pandemic puts pressure on healthcare systems worldwide, the computed tomography image based AI diagnostic system has become a sustainable solution for early diagnosis. However, the model-wise vulnerability under adversarial perturbation hinders its deployment in practical situation. The existing adversarial training strategies are difficult to generalized into medical imaging field challenged by complex medical texture features. To overcome this challenge, we propose a Contour Attention Preserving (CAP) method based on lung cavity edge extraction. The contour prior features are…
Advancing Diagnostic Precision: Leveraging Machine Learning Techniques for Accurate Detection of Covid-19, Pneumonia, and Tuberculosis in Chest X-Ray Images
The infection of respiratory coronavirus disease 2019 (COVID-19) starts with the upper respiratory tract and as the virus grows, the infection can progress to lungs and develop pneumonia. The conventional way of COVID-19 diagnosis is reverse transcription polymerase chain reaction (RT-PCR), which is less sensitive during early stages; especially if the patient is asymptomatic, which may further cause more severe pneumonia. In this context, several deep learning models have been proposed to identify pulmonary infections using publicly available chest X-ray (CXR) image datasets for early diagnos…
To develop a deep-learning model that integrates radiomics analysis for enhanced performance of COVID-19 and Non-COVID-19 pneumonia detection using chest X-ray image, two deep-learning models were trained based on a pre-trained VGG-16 architecture: in the 1st model, X-ray image was the sole input; in the 2nd model, X-ray image and 2 radiomic feature maps (RFM) selected by the saliency map analysis of the 1st model were stacked as the input. Both models were developed using 812 chest X-ray images with 262/288/262 COVID-19/Non-COVID-19 pneumonia/healthy cases, and 649/163 cases were assigned as …
The issue of COVID-19, increasing with a massive mortality rate. This led to the WHO declaring it as a pandemic. In this situation, it is crucial to perform efficient and fast diagnosis. The reverse transcript polymerase chain reaction (RTPCR) test is conducted to detect the presence of SARS-CoV-2. This test is time-consuming and instead chest CT (or Chest X-ray) can be used for a fast and accurate diagnosis. Automated diagnosis is considered to be important as it reduces human effort and provides accurate and low-cost tests. The contributions of our research are three-fold. First, it is aimed…
JP Morgan Chase（摩根大通）；University of Cambridge（剑桥大学）
Chest Computational Tomography (CT) scans present low cost, speed and objectivity for COVID-19 diagnosis and deep learning methods have shown great promise in assisting the analysis and interpretation of these images. Most hospitals or countries can train their own models using in-house data, however empirical evidence shows that those models perform poorly when tested on new unseen cases, surfacing the need for coordinated global collaboration. Due to privacy regulations, medical data sharing between hospitals and nations is extremely difficult. We propose a GAN-augmented federated learning m…
University of Assiut（艾斯尤特大学）；Birmingham City University（伯明翰城市大学）
Due to the high availability of large-scale annotated image datasets, knowledge transfer from pre-trained models showed outstanding performance in medical image classification. However, building a robust image classification model for datasets with data irregularity or imbalanced classes can be a very challenging task, especially in the medical imaging domain. In this paper, we propose a novel deep convolutional neural network, we called Self Supervised Super Sample Decomposition for Transfer learning (4S-DT) model. 4S-DT encourages a coarse-to-fine transfer learning from large-scale image rec…
ETH Zurich（苏黎世联邦理工学院）；Medizinische Hochschule Brandenburg Theodor Fontane（勃兰登堡特奥多尔·冯塔纳医学院）
Controlling the COVID-19 pandemic largely hinges upon the existence of fast, safe, and highly-available diagnostic tools. Ultrasound, in contrast to CT or X-Ray, has many practical advantages and can serve as a globally-applicable first-line examination technique. We provide the largest publicly available lung ultrasound (US) dataset for COVID-19 consisting of 106 videos from three classes (COVID-19, bacterial pneumonia, and healthy controls); curated and approved by medical experts. On this dataset, we perform an in-depth study of the value of deep learning methods for differential diagnosis …
Under the epidemic of the novel coronavirus disease 2019 (COVID-19), chest X-ray computed tomography imaging is being used for effectively screening COVID-19 patients. The development of computer-aided systems based on deep neural networks (DNNs) has been advanced, to rapidly and accurately detect COVID-19 cases, because the need for expert radiologists, who are limited in number, forms a bottleneck for the screening. However, so far, the vulnerability of DNN-based systems has been poorly evaluated, although DNNs are vulnerable to a single perturbation, called universal adversarial perturbatio…
Halfway to 3D: Ensembling 2.5D and 3D Models for Robust COVID-19 CT Diagnosis
VNUHCM University of Science, Vietnam National University, Vietnam（越南国家大学科学大学）；Ho Chi Minh University of Technology, Vietnam National University, Vietnam（胡志明技术大学，越南国家大学）；The University of Alabama at Birmingham, United States（美国伯明翰大学）
Concordia University（康考迪亚大学）；McGill University（麦吉尔大学）；Tehran University of Medical Sciences（德黑兰医科大学）；University of Montreal（蒙特利尔大学）；University of Toronto（多伦多大学）
The objective of this study is to develop a robust deep learning-based framework to distinguish COVID-19, Community-Acquired Pneumonia (CAP), and Normal cases based on chest CT scans acquired in different imaging centers using various protocols, and radiation doses. We showed that while our proposed model is trained on a relatively small dataset acquired from only one imaging center using a specific scanning protocol, the model performs well on heterogeneous test sets obtained by multiple scanners using different technical parameters. We also showed that the model can be updated via an unsuper…
