噪声激活DNA在纳米多孔凝胶中的快速运动
Noise Activated Fast Locomotion of DNA through Frictional Landscape of Nanoporous Gel
摘要：
据推测，凝胶基质和DNA分子之间的非线性固体摩擦会抑制DNA在电泳过程中通过凝胶纳米孔的运动。在这篇文章中，它表明，外部噪声可以减轻固体摩擦的影响，从而提高在电泳设置中的DNA的流动性。在存在噪声的情况下，与常规电泳相比，DNA的迁移率增加超过~ 113%。虽然在高噪声功率下，DNA表现出Arrhenius动力学，但在低噪声功率下，超Arrhenius动力学表明DNA分子的激活运动的集体行为。随机模拟修改后的Langevin动力学与不对称的孔径分布的琼脂糖凝胶成功地预测了DNA分子的流动性，并揭示了整体动力学的显着特点。这种“噪音润滑性”可能具有从分子到宏观运动的更广泛的适用性。
英文摘要：
It is hypothesized that nonlinear solid friction between the gel matrix and DNA molecules inhibits the motion of DNA through the nanopores of the gel during electrophoresis. In this article, it is demonstrated that external noise can alleviate the effect of solid friction, thus enhancing the mobility of DNA in an electrophoretic setting. In the presence of noise, the mobility of DNA increases by more than ~113 % compared to conventional electrophoresis. Although at a high power of noise, DNA exhibits Arrhenius kinetics, at a low power of noise, super Arrhenius kinetics suggest the collective behavior of the activated motion of DNA molecules. Stochastic simulation following modified Langevin dynamics with the asymmetric pore size distribution of the agarose gel successfully predicts the mobility of DNA molecules and reveals the salient features of the overall dynamics. This 'noise lubricity' may have broader applicability from molecular to macroscopic locomotion.
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