Pulmonary fibrosis is a devastating chronic lung disease that causes irreparable lung tissue scarring and damage, resulting in progressive loss in lung capacity and has no known cure. A critical step in the treatment and management of pulmonary fibrosis is the assessment of lung function decline, with computed tomography (CT) imaging being a particularly effective method for determining the extent of lung damage caused by pulmonary fibrosis. Motivated by this, we introduce Fibrosis-Net, a deep convolutional neural network design tailored for the prediction of pulmonary fibrosis progression from chest CT images. More specifically, machine-driven design exploration was leveraged to determine a strong architectural design for CT lung analysis, upon which we build a customized network design tailored for predicting forced vital capacity (FVC) based on a patient's CT scan, initial spirometry measurement, and clinical metadata. Finally, we leverage an explainability-driven performance validation strategy to study the decision-making behaviour of Fibrosis-Net as to verify that predictions are based on relevant visual indicators in CT images. Experiments using a patient cohort from the OSIC Pulmonary Fibrosis Progression Challenge showed that the proposed Fibrosis-Net is able to achieve a significantly higher modified Laplace Log Likelihood score than the winning solutions on the challenge. Furthermore, explainability-driven performance validation demonstrated that the proposed Fibrosis-Net exhibits correct decision-making behaviour by leveraging clinically-relevant visual indicators in CT images when making predictions on pulmonary fibrosis progress. While Fibrosis-Net is not yet a production-ready clinical assessment solution, we hope that its release in open source manner will encourage researchers, clinicians, and citizen data scientists alike to leverage and build upon it.
Brainekt AI Lab（Brainekt AI 实验室）；Khulna University of Engineering & Technology（库尔纳工程技术大学）；Ryerson University（瑞尔森大学）；Vector Institute for AI（向量人工智能研究院）；University Health Network (UHN)（大学健康网络）；University of Toronto（多伦多大学）
Idiopathic pulmonary fibrosis (IPF) is a restrictive interstitial lung disease that causes lung function decline by lung tissue scarring. Although lung function decline is assessed by the forced vital capacity (FVC), determining the accurate progression of IPF remains a challenge. To address this challenge, we proposed Fibro-CoSANet, a novel end-to-end multi-modal learning-based approach, to predict the FVC decline. Fibro-CoSANet utilized CT images and demographic information in convolutional neural network frameworks with a stacked attention layer. Extensive experiments on the OSIC Pulmonary …
Idiopathic Pulmonary Fibrosis (IPF) is an inexorably progressive fibrotic lung disease with a variable and unpredictable rate of progression. CT scans of the lungs inform clinical assessment of IPF patients and contain pertinent information related to disease progression. In this work, we propose a multi-modal method that uses neural networks and memory banks to predict the survival of IPF patients using clinical and imaging data. The majority of clinical IPF patient records have missing data (e.g. missing lung function tests). To this end, we propose a probabilistic model that captures the de…
University College London（伦敦大学学院）；KU Leuven（鲁汶大学）；University Hospitals Leuven（鲁汶大学医院）；University of Antwerp（安特卫普大学）
Several chronic lung diseases, like idiopathic pulmonary fibrosis (IPF) are characterised by abnormal dilatation of the airways. Quantification of airway features on computed tomography (CT) can help characterise disease progression. Physics based airway measurement algorithms have been developed, but have met with limited success in part due to the sheer diversity of airway morphology seen in clinical practice. Supervised learning methods are also not feasible due to the high cost of obtaining precise airway annotations. We propose synthesising airways by style transfer using perceptual losse…
Pulmonary vessel segmentation is important for clinical diagnosis of pulmonary diseases, while is also challenging due to the complicated structure. In this work, we present an effective framework and refinement process of pulmonary vessel segmentation from chest computed tomographic (CT) images. The key to our approach is a 2.5D segmentation network applied from three orthogonal axes, which presents a robust and fully automated pulmonary vessel segmentation result with lower network complexity and memory usage compared to 3D networks. The slice radius is introduced to convolve the adjacent in…
University of Electronic Science and Technology of China（电子科技大学）；University of Maryland School of Medicine（马里兰大学医学院）；Rutgers, the State University of New Jersey（罗格斯大学（新泽西州立大学））
Computed Tomography (CT) plays an important role in monitoring radiation-induced Pulmonary Fibrosis (PF), where accurate segmentation of the PF lesions is highly desired for diagnosis and treatment follow-up. However, the task is challenged by ambiguous boundary, irregular shape, various position and size of the lesions, as well as the difficulty in acquiring a large set of annotated volumetric images for training. To overcome these problems, we propose a novel convolutional neural network called PF-Net and incorporate it into a semi-supervised learning framework based on Iterative Confidence-…
National Yang Ming Chiao Tung University（阳明交通大学）；National Cheng Kung University Hospital（成功大学附属医院）；National Cheng Kung University（成功大学）
The purpose of this research is to develop a system that generates simulated computed tomography pulmonary angiography (CTPA) images clinically for pulmonary embolism diagnoses. Nowadays, CTPA images are the gold standard computerized detection method to determine and identify the symptoms of pulmonary embolism (PE), although performing CTPA is harmful for patients and also expensive. Therefore, we aim to detect possible PE patients through CT images. The system will simulate CTPA images with deep learning models for the identification of PE patients' symptoms, providing physicians with anothe…
National University of Sciences and Technology（国立科技大学）；Khalifa University（哈利法大学）
Pulmonary diseases can cause severe respiratory problems, leading to sudden death if not treated timely. Many researchers have utilized deep learning systems to diagnose pulmonary disorders using chest X-rays (CXRs). However, such systems require exhaustive training efforts on large-scale data to effectively diagnose chest abnormalities. Furthermore, procuring such large-scale data is often infeasible and impractical, especially for rare diseases. With the recent advances in incremental learning, researchers have periodically tuned deep neural networks to learn different classification tasks w…
4D VQ-GAN: Synthesising Medical Scans at Any Time Point for Personalised Disease Progression Modelling of Idiopathic Pulmonary Fibrosis
Hawkes Institute, University College London（伦敦大学学院霍克斯研究所）；Department of Computer Science, University College London（伦敦大学学院计算机科学系）；Department of Med. Physics & Biomedical Engineering, University College London（伦敦大学学院医学物理与生物医学工程系）；Department of Respiratory Medicine, University Hospitals Leuven（鲁汶大学医院呼吸医学科）；NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton（南安普顿大学NIHR南安普顿生物医学研究中心与临床与实验科学系）；UCL Respiratory, University College London（伦敦大学学院呼吸科）
Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Harvard Medical School（哈佛医学院）；Massachusetts Institute of Technology（麻省理工学院）；Philips Research（飞利浦研究院）
Purpose: To develop a machine learning model to classify the severity grades of pulmonary edema on chest radiographs. Materials and Methods: In this retrospective study, 369,071 chest radiographs and associated radiology reports from 64,581 (mean age, 51.71; 54.51% women) patients from the MIMIC-CXR chest radiograph dataset were included. This dataset was split into patients with and without congestive heart failure (CHF). Pulmonary edema severity labels from the associated radiology reports were extracted from patients with CHF as four different ordinal levels: 0, no edema; 1, vascular conges…
With more than 60,000 deaths annually in the United States, Pulmonary Embolism (PE) is among the most fatal cardiovascular diseases. It is caused by an artery blockage in the lung; confirming its presence is time-consuming and is prone to over-diagnosis. The utilization of automated PE detection systems is critical for diagnostic accuracy and efficiency. In this study we propose a two-stage attention-based CNN-LSTM network for predicting PE, its associated type (chronic, acute) and corresponding location (leftsided, rightsided or central) on computed tomography (CT) examinations. We trained ou…
Fuzhou University（福州大学）；Fujian Medical University Union Hospital（福建医科大学附属协和医院）
With the development of medical computer-aided diagnostic systems, pulmonary artery-vein(A/V) separation plays a crucial role in assisting doctors in preoperative planning for lung cancer surgery. However, distinguishing arterial from venous irrigation in chest CT images remains a challenge due to the similarity and complex structure of the arteries and veins. We propose a novel method for automatic separation of pulmonary arteries and veins from chest CT images. The method consists of three parts. First, global connection information and local feature information are used to construct a compl…
Tuberculosis (TB) is a contagious bacterial airborne disease, and is one of the top 10 causes of death worldwide. According to the World Health Organization (WHO), around 1.8 billion people are infected with TB and 1.6 million deaths were reported in 2018. More importantly,95% of cases and deaths were from developing countries. Yet, TB is a completely curable disease through early diagnosis. To achieve this goal one of the key requirements is efficient utilization of existing diagnostic technologies, among which chest X-ray is the first line of diagnostic tool used for screening for active TB.…
The University of British Columbia（不列颠哥伦比亚大学）；Xtract AI；Element AI；SapienML；AWS, Worldwide Public Sector（亚马逊云科技全球公共部门）
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly spread into a global pandemic. A form of pneumonia, presenting as opacities with in a patient's lungs, is the most common presentation associated with this virus, and great attention has gone into how these changes relate to patient morbidity and mortality. In this work we provide open source models for the segmentation of patterns of pulmonary opacification on chest Computed Tomography (CT) scans which have been correlated with various stages and severities of infection. We have collected 663 chest CT scans of COVID-…
Recent works show that Generative Adversarial Networks (GANs) can be successfully applied to chest X-ray data augmentation for lung disease recognition. However, the implausible and distorted pathology features generated from the less than perfect generator may lead to wrong clinical decisions. Why not keep the original pathology region? We proposed a novel approach that allows our generative model to generate high quality plausible images that contain undistorted pathology areas. The main idea is to design a training scheme based on an image-to-image translation network to introduce variation…
Scientific Computing and Imaging Institute, University of Utah（犹他大学科学计算与成像研究所）；Department of Radiology and Imaging Sciences, University of Utah（犹他大学放射学与影像科学系）
Knowledge of what spatial elements of medical images deep learning methods use as evidence is important for model interpretability, trustiness, and validation. There is a lack of such techniques for models in regression tasks. We propose a method, called visualization for regression with a generative adversarial network (VR-GAN), for formulating adversarial training specifically for datasets containing regression target values characterizing disease severity. We use a conditional generative adversarial network where the generator attempts to learn to shift the output of a regressor through cre…
Suppression of thoracic bone shadows on chest X-rays (CXRs) has been indicated to improve the diagnosis of pulmonary disease. Previous approaches can be categorized as unsupervised physical and supervised deep learning models. Nevertheless, with physical models able to preserve morphological details but at the cost of extremely long processing time, existing DL methods face challenges of gathering sufficient/qualitative ground truth (GT) for robust training, thus leading to failure in maintaining clinically acceptable false positive rates. We hereby propose a generalizable yet efficient workfl…
National Yang Ming Chiao Tung University（国立阳明交通大学）；National Cheng Kung University Hospital（国立成功大学医院）；National Cheng Kung University（国立成功大学）
The clinical symptoms of pulmonary embolism (PE) are very diverse and non-specific, which makes it difficult to diagnose. In addition, pulmonary embolism has multiple triggers and is one of the major causes of vascular death. Therefore, if it can be detected and treated quickly, it can significantly reduce the risk of death in hospitalized patients. In the detection process, the cost of computed tomography pulmonary angiography (CTPA) is high, and angiography requires the injection of contrast agents, which increase the risk of damage to the patient. Therefore, this study will use a deep learn…
Hunting imaging biomarkers in pulmonary fibrosis: Benchmarks of the AIIB23 challenge
Imperial College London（帝国理工学院）；Royal Brompton Hospital（皇家布朗普顿医院）；University of Parma（帕尔马大学）；Shanghai MicroPort MedBot (Group) Co., Ltd.（上海微创医疗机器人（集团）股份有限公司）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司）；Shanghai Jiao Tong University（上海交通大学）；Fudan University（复旦大学）；Cambridge International Exam Centre in Shanghai Experimental School（上海实验学校剑桥国际考试中心）；InferVision Medical Technology Co., Ltd.（推想医疗科技股份有限公司）；Shanghai MediWorks Precision Instruments Co., Ltd（上海美沃克斯精密仪器有限公司）；Sanmed Biotech Ltd.（三曼生物科技有限公司）；University of Cambridge（剑桥大学）；University of Palermo（巴勒莫大学）；IRCCS Istituto delle Scienze Neurologiche di Bologna（IRCCS博洛尼亚神经科学研究所）；Istituto Italiano di Tecnologia（意大利技术研究院）；University of Oxford（牛津大学）；Hong Kong University of Science and Technology (Guangzhou)（香港科技大学（广州））；INSA Rouen Normandie（鲁昂国立应用科学学院）；Univ Rouen Normandie（鲁昂诺曼底大学）；Université Le Havre Normandie（勒阿弗尔诺曼底大学）；Henri Becquerel Cancer Center（亨利·贝克勒尔癌症中心）；Wake Forest University School of Medicine（维克森林大学医学院）；University College London（伦敦大学学院）；King's College London（伦敦国王学院）
University of Cambridge（剑桥大学）；Indian Institute of Technology Madras（马德拉斯印度理工学院）；Indian Institute of Technology Patna（巴特那印度理工学院）；Kalinga Institute of Industrial Technology Bhubaneswar（布巴内斯瓦尔卡林加工业技术学院）
This paper introduces a paradigm of smartphone application based disease diagnostics that may completely revolutionise the way healthcare services are being provided. Although primarily aimed to assist the problems in rendering the healthcare services during the coronavirus pandemic, the model can also be extended to identify the exact disease that the patient is caught with from a broad spectrum of pulmonary diseases. The app inputs Chest X-Ray images captured from the mobile camera which is then relayed to the AI architecture in a cloud platform, and diagnoses the disease with state of the a…
National Research Council Canada（加拿大国家研究委员会）；University of Waterloo（滑铁卢大学）；Ford Motor Company（福特汽车公司）
Chest radiography is an effective screening tool for diagnosing pulmonary diseases. In computer-aided diagnosis, extracting the relevant region of interest, i.e., isolating the lung region of each radiography image, can be an essential step towards improved performance in diagnosing pulmonary disorders. Methods: In this work, we propose a deep learning approach to enhance abnormal chest x-ray (CXR) identification performance through segmentations. Our approach is designed in a cascaded manner and incorporates two modules: a deep neural network with criss-cross attention modules (XLSor) for loc…
Seoul National University Hospital（首尔大学医院）；Massachusetts General Hospital（麻省总医院）；Kyungpook National University（庆北国立大学）；Yeungnam University College of Medicine（岭南大学医学院）；Catholic University of Daegu School of Medicine（大邱加图立大学医学院）；Keimyung University School of Medicine（启明大学医学院）
Purpose. Imaging plays an important role in assessing severity of COVID 19 pneumonia. However, semantic interpretation of chest radiography (CXR) findings does not include quantitative description of radiographic opacities. Most current AI assisted CXR image analysis framework do not quantify for regional variations of disease. To address these, we proposed a four region lung segmentation method to assist accurate quantification of COVID 19 pneumonia. Methods. A segmentation model to separate left and right lung is firstly applied, and then a carina and left hilum detection network is used, wh…
Tsinghua University（清华大学）；Z 2 Sky Technologies Inc.（Z2天空科技公司）；Affiliated Hospital of Guizhou Medical University（贵州医科大学附属医院）；Naval Medical University（海军军医大学）；Changzheng Hospital（长征医院）；University of Science and Technology of China（中国科学技术大学）
Digital chest tomosynthesis (DCT) is a technique to produce sectional 3D images of a human chest for pulmonary disease screening, with 2D X-ray projections taken within an extremely limited range of angles. However, under the limited angle scenario, DCT contains strong artifacts caused by the presence of ribs, jamming the imaging quality of the lung area. Recently, great progress has been achieved for rib suppression in a single X-ray image, to reveal a clearer lung texture. We firstly extend the rib suppression problem to the 3D case at the software level. We propose a $\textbf{T}$omosynthesi…
Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
Accurately and precisely characterizing the morphology of small pulmonary structures from Computed Tomography (CT) images, such as airways and vessels, is becoming of great importance for diagnosis of pulmonary diseases. The smaller conducting airways are the major site of increased airflow resistance in chronic obstructive pulmonary disease (COPD), while accurately sizing vessels can help identify arterial and venous changes in lung regions that may determine future disorders. However, traditional methods are often limited due to image resolution and artifacts. We propose a Convolutional Neur…
Detection of pulmonary pathologies using convolutional neural networks, Data Augmentation, ResNet50 and Vision Transformers
Universidad Abierta Interamericana（泛美开放大学）；Faculty of Information Technology（信息技术学院）；Center for Advanced Studies in Information Technology（信息技术高级研究中心）；Interamerican Open University（泛美开放大学）
MEDPSeg: Hierarchical polymorphic multitask learning for the segmentation of ground-glass opacities, consolidation, and pulmonary structures on computed tomography
School of Electrical and Computer Engineering, Universidade Estadual de Campinas（坎皮纳斯州立大学电气与计算机工程学院）；University of Iowa（爱荷华大学）
Google Health（谷歌健康）；Advanced Clinical（先进临床）；Apollo Radiology International（阿波罗国际放射学）；Center of Infectious Disease Research in Zambia（赞比亚传染病研究中心）；Sibanye Stillwater（斯班耶-斯蒂尔沃特）；Clickmedix
Tuberculosis (TB) is a top-10 cause of death worldwide. Though the WHO recommends chest radiographs (CXRs) for TB screening, the limited availability of CXR interpretation is a barrier. We trained a deep learning system (DLS) to detect active pulmonary TB using CXRs from 9 countries across Africa, Asia, and Europe, and utilized large-scale CXR pretraining, attention pooling, and noisy student semi-supervised learning. Evaluation was on (1) a combined test set spanning China, India, US, and Zambia, and (2) an independent mining population in South Africa. Given WHO targets of 90% sensitivity an…
AirMorph: Topology-Preserving Deep Learning for Pulmonary Airway Analysis
Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学医疗机器人研究院）；Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University（上海交通大学图像处理与模式识别研究所）；Shanghai Chest Hospital（上海市胸科医院）
Data Science Institute（数据科学研究所）；University of Arizona（亚利桑那大学）
We propose a deep learning based method for classification of commonly occurring pathologies in chest X-ray images. The vast number of publicly available chest X-ray images provides the data necessary for successfully employing deep learning methodologies to reduce the misdiagnosis of thoracic diseases. We applied our method to the classification of two example pathologies, pulmonary nodules and cardiomegaly, and we compared the performance of our method to three existing methods. The results show an improvement in AUC for detection of nodules and cardiomegaly compared to the existing methods.
Indian Institute of Technology Kharagpur（印度理工学院卡哈拉格普尔分校）；Apollo Gleneagles Hospital（阿波罗格伦伊格尔斯医院）；Intel Technology India Pvt. Ltd.（英特尔技术印度私人有限公司）
Chest radiographs are primarily employed for the screening of cardio, thoracic and pulmonary conditions. Machine learning based automated solutions are being developed to reduce the burden of routine screening on Radiologists, allowing them to focus on critical cases. While recent efforts demonstrate the use of ensemble of deep convolutional neural networks(CNN), they do not take disease comorbidity into consideration, thus lowering their screening performance. To address this issue, we propose a Graph Neural Network (GNN) based solution to obtain ensemble predictions which models the dependen…
Objectives: To compare artificial intelligence (AI) as a second reader in detecting lung nodules on chest X-rays (CXR) versus radiologists of two binational institutions, and to evaluate AI performance when using two different modes: automated versus assisted (additional remote radiologist review). Methods: The CXR public database (n = 247) of the Japanese Society of Radiological Technology with various types and sizes of lung nodules was analyzed. Eight radiologists evaluated the CXR images with regard to the presence of lung nodules and nodule conspicuity. After radiologist review, the AI so…
Charité Universitätsmedizin Berlin（柏林夏里特医学院）；Technische Universität München（慕尼黑工业大学）
Segmentation of pulmonary infiltrates can help assess severity of COVID-19, but manual segmentation is labor and time-intensive. Using neural networks to segment pulmonary infiltrates would enable automation of this task. However, training a 3D U-Net from computed tomography (CT) data is time- and resource-intensive. In this work, we therefore developed and tested a solution on how transfer learning can be used to train state-of-the-art segmentation models on limited hardware and in shorter time. We use the recently published RSNA International COVID-19 Open Radiology Database (RICORD) to trai…
In this paper, a 3D-RegNet-based neural network is proposed for diagnosing the physical condition of patients with coronavirus (Covid-19) infection. In the application of clinical medicine, lung CT images are utilized by practitioners to determine whether a patient is infected with coronavirus. However, there are some laybacks can be considered regarding to this diagnostic method, such as time consuming and low accuracy. As a relatively large organ of human body, important spatial features would be lost if the lungs were diagnosed utilizing two dimensional slice image. Therefore, in this paper…
School of Electrical and Automation Engineering, East China Jiaotong University（华东交通大学电气与自动化工程学院）；School of Computer Science, Northwestern Polytechnical University（西北工业大学计算机学院）；School of Software, East China Jiaotong University（华东交通大学软件学院）；College of Biology, Hunan University（湖南大学生物学院）
Priori knowledge of pulmonary anatomy plays a vital role in diagnosis of lung diseases. In CT images, pulmonary fissure segmentation is a formidable mission due to various of factors. To address the challenge, an useful approach based on ODoS filter and shape features is presented for pulmonary fissure segmentation. Here, we adopt an ODoS filter by merging the orientation information and magnitude information to highlight structure features for fissure enhancement, which can effectively distinguish between pulmonary fissures and clutters. Motivated by the fact that pulmonary fissures appear as…
Zebra Medical Vision Ltd（斑马医疗视觉有限公司）；Rabin Medical Center（拉宾医疗中心）
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide. Identifying those at highest risk of deterioration would allow more effective distribution of preventative and surveillance resources. Secondary pulmonary hypertension is a manifestation of advanced COPD, which can be reliably diagnosed by the main Pulmonary Artery (PA) to Ascending Aorta (Ao) ratio. In effect, a PA diameter to Ao diameter ratio of greater than 1 has been demonstrated to be a reliable marker of increased pulmonary arterial pressure. Although clinically valuable and readily vis…
Total lung volume is an important quantitative biomarker and is used for the assessment of restrictive lung diseases. In this study, we investigate the performance of several deep-learning approaches for automated measurement of total lung volume from chest radiographs. 7621 posteroanterior and lateral view chest radiographs (CXR) were collected from patients with chest CT available. Similarly, 928 CXR studies were chosen from patients with pulmonary function test (PFT) results. The reference total lung volume was calculated from lung segmentation on CT or PFT data, respectively. This dataset …
With COVID-19 cases rising rapidly, deep learning has emerged as a promising diagnosis technique. However, identifying the most accurate models to characterize COVID-19 patients is challenging because comparing results obtained with different types of data and acquisition processes is non-trivial. In this paper we designed, evaluated, and compared the performance of 20 convolutional neutral networks in classifying patients as COVID-19 positive, healthy, or suffering from other pulmonary lung infections based on Chest CT scans, serving as the first to consider the EfficientNet family for COVID-…
New York University（纽约大学）；The University of Alabama（阿拉巴马大学）；Université Quisqueya（基斯克亚大学）；NYU Grossman School of Medicine（纽约大学格罗斯曼医学院）
Chest computed tomography (CT) imaging adds valuable insight in the diagnosis and management of pulmonary infectious diseases, like tuberculosis (TB). However, due to the cost and resource limitations, only X-ray images may be available for initial diagnosis or follow up comparison imaging during treatment. Due to their projective nature, X-rays images may be more difficult to interpret by clinicians. The lack of publicly available paired X-ray and CT image datasets makes it challenging to train a 3D reconstruction model. In addition, Chest X-ray radiology may rely on different device modaliti…
X-ray2CTPA: Leveraging Diffusion Models to Enhance Pulmonary Embolism Classification
Faculty of Engineering, Tel Aviv University（工程学院，特拉维夫大学）；Division of Data-Driven and Digital Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai（数据驱动与数字医学部，医学部，Mount Sinai医学院）；Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Israel（诊断影像科，Sheba 医疗中心，Ramat Gan，以色列）；Department of Radiology, Icahn School of Medicine, Mount Sinai（放射科，Icahn医学院，Mount Sinai）
University of Copenhagen（哥本哈根大学）；Cerebriu AS（Cerebriu公司）；Technical University of Denmark（丹麦技术大学）
Pulmonary opacification is the inflammation in the lungs caused by many respiratory ailments, including the novel corona virus disease 2019 (COVID-19). Chest X-rays (CXRs) with such opacifications render regions of lungs imperceptible, making it difficult to perform automated image analysis on them. In this work, we focus on segmenting lungs from such abnormal CXRs as part of a pipeline aimed at automated risk scoring of COVID-19 from CXRs. We treat the high opacity regions as missing data and present a modified CNN-based image segmentation network that utilizes a deep generative model for dat…
Université de Haute-Alsace（上阿尔萨斯大学）；Université de Strasbourg（斯特拉斯堡大学）；University of Lille（里尔大学）；YNCREA-ISEN Lille（里尔YNCREA-ISEN工程学院）；University of the Basque Country（巴斯克大学）；IKERBASQUE, Basque Foundation for Science（伊克尔巴斯克巴斯克科学基金会）；The University of Tokyo（东京大学）；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；CHU Lille（里尔大学医院）
Coronavirus disease 2019 (COVID-19) is an infectious disease with first symptoms similar to the flu. COVID-19 appeared first in China and very quickly spreads to the rest of the world, causing then the 2019-20 coronavirus pandemic. In many cases, this disease causes pneumonia. Since pulmonary infections can be observed through radiography images, this paper investigates deep learning methods for automatically analyzing query chest X-ray images with the hope to bring precision tools to health professionals towards screening the COVID-19 and diagnosing confirmed patients. In this context, traini…
COVID-19 is a new pulmonary disease which is driving stress to the hospitals due to the large number of cases worldwide. Imaging of lungs can play a key role in monitoring of the healthy status. Non-contrast chest computed tomography (CT) has been used for this purpose, mainly in China, with a significant success. However, this approach cannot be used massively mainly for both high risk and cost and in some countries also because this tool is not extensively available. Alternatively, chest X-ray, although less sensitive than CT-scan, can provide important information about the evolution of pul…
Yale University（耶鲁大学）；IBM Almaden Research Center（IBM阿尔马登研究中心）；New York University（纽约大学）
Pulmonary Embolism (PE) is a life-threatening disorder associated with high mortality and morbidity. Prompt diagnosis and immediate initiation of therapeutic action is important. We explored a deep learning model to detect PE on volumetric contrast-enhanced chest CT scans using a 2-stage training strategy. First, a residual convolutional neural network (ResNet) was trained using annotated 2D images. In addition to the classification loss, an attention loss was added during training to help the network focus attention on PE. Next, a recurrent network was used to scan sequentially through the fe…
