Learning Whole-Slide Segmentation from Inexact and Incomplete Labels using Tissue Graphs
IBM Zurich Research Lab（IBM苏黎世研究实验室）；EPFL（洛桑联邦理工学院）；APHP. Centre（巴黎公立医院中心）；Cochin hospital（科钦医院）；Université de Paris（巴黎大学）；ETH Zurich（苏黎世联邦理工学院）；Uppsala University（乌普萨拉大学）
Valentin Anklin, Pushpak Pati, Guillaume Jaume, Behzad Bozorgtabar, Antonio Foncubierta-Rodríguez, Jean-Philippe Thiran, Mathilde Sibony, Maria Gabrani, Orcun Goksel
Segmenting histology images into diagnostically relevant regions is imperative to support timely and reliable decisions by pathologists. To this end, computer-aided techniques have been proposed to delineate relevant regions in scanned histology slides. However, the techniques necessitate task-specific large datasets of annotated pixels, which is tedious, time-consuming, expensive, and infeasible to acquire for many histology tasks. Thus, weakly-supervised semantic segmentation techniques are proposed to utilize weak supervision that is cheaper and quicker to acquire. In this paper, we propose SegGini, a weakly supervised segmentation method using graphs, that can utilize weak multiplex annotations, i.e. inexact and incomplete annotations, to segment arbitrary and large images, scaling from tissue microarray (TMA) to whole slide image (WSI). Formally, SegGini constructs a tissue-graph representation for an input histology image, where the graph nodes depict tissue regions. Then, it performs weakly-supervised segmentation via node classification by using inexact image-level labels, incomplete scribbles, or both. We evaluated SegGini on two public prostate cancer datasets containing TMAs and WSIs. Our method achieved state-of-the-art segmentation performance on both datasets for various annotation settings while being comparable to a pathologist baseline.
Tissue segmentation is an important pre-requisite for efficient and accurate diagnostics in digital pathology. However, it is well known that whole-slide scanners can fail in detecting all tissue regions, for example due to the tissue type, or due to weak staining because their tissue detection algorithms are not robust enough. In this paper, we introduce two different convolutional neural network architectures for whole slide image segmentation to accurately identify the tissue sections. We also compare the algorithms to a published traditional method. We collected 54 whole slide images with …
Khalifa University（哈利法大学）；Beihang University（北京航空航天大学）；University of Louisville（路易斯维尔大学）
Prostate cancer (PCa) is the second deadliest form of cancer in males, and it can be clinically graded by examining the structural representations of Gleason tissues. This paper proposes \RV{a new method} for segmenting the Gleason tissues \RV{(patch-wise) in order to grade PCa from the whole slide images (WSI).} Also, the proposed approach encompasses two main contributions: 1) A synergy of hybrid dilation factors and hierarchical decomposition of latent space representation for effective Gleason tissues extraction, and 2) A three-tiered loss function which can penalize different semantic seg…
An Accelerated Pipeline for Multi-label Renal Pathology Image Segmentation at the Whole Slide Image Level
Vanderbilt University（范德堡大学）；The University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Vanderbilt University Medical Center（范德堡大学医学中心）；Georgia State University（佐治亚州立大学）
University of Washington（华盛顿大学）；University of Vermont（佛蒙特大学）
We trained and applied an encoder-decoder model to semantically segment breast biopsy images into biologically meaningful tissue labels. Since conventional encoder-decoder networks cannot be applied directly on large biopsy images and the different sized structures in biopsies present novel challenges, we propose four modifications: (1) an input-aware encoding block to compensate for information loss, (2) a new dense connection pattern between encoder and decoder, (3) dense and sparse decoders to combine multi-level features, (4) a multi-resolution network that fuses the results of encoder-dec…
Radboud University Medical Center（拉德堡德大学医学中心）；Institute of Experimental Immunology, University of Zurich（苏黎世大学实验免疫学研究所）；Center for Medical Image Science and Visualization, Linköping University（林雪平大学医学影像科学与可视化中心）
We propose HookNet, a semantic segmentation model for histopathology whole-slide images, which combines context and details via multiple branches of encoder-decoder convolutional neural networks. Concentricpatches at multiple resolutions with different fields of view are used to feed different branches of HookNet, and intermediate representations are combined via a hooking mechanism. We describe a framework to design and train HookNet for achieving high-resolution semantic segmentation and introduce constraints to guarantee pixel-wise alignment in feature maps during hooking. We show the advan…
Semantic Segmentation Based Quality Control of Histopathology Whole Slide Images
Indian Institute of Technology - Bombay（印度理工学院-博伊斯班加分校）；Department of Electrical Engineering（电气工程系）；Koita Centre for Digital Health（数字健康中心）；Indian Council of Medical Research（印度医学研究委员会）；National Institute for Research in Digital Health and Data Science（数字健康与数据科学国家研究所）；Tata Memorial Centre – ACTREC（塔塔纪念中心–ACTREC）；HBNI
Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Weill Cornell Graduate School for Medical Sciences（威尔康奈尔医学研究生院）
Pathologic analysis of surgical excision specimens for breast carcinoma is important to evaluate the completeness of surgical excision and has implications for future treatment. This analysis is performed manually by pathologists reviewing histologic slides prepared from formalin-fixed tissue. In this paper, we present Deep Multi-Magnification Network trained by partial annotation for automated multi-class tissue segmentation by a set of patches from multiple magnifications in digitized whole slide images. Our proposed architecture with multi-encoder, multi-decoder, and multi-concatenation out…
To achieve minimum DNA input and tumor purity requirements for next-generation sequencing (NGS), pathologists visually estimate macrodissection and slide count decisions. Misestimation may cause tissue waste and increased laboratory costs. We developed an AI-augmented smart pathology review system (SmartPath) to empower pathologists with quantitative metrics for determining tissue extraction parameters. Using digitized H&E-stained FFPE slides as inputs, SmartPath segments tumors, extracts cell-based features, and suggests macrodissection areas. To predict DNA yield per slide, the extracted fea…
Roche Innovation Center Munich（罗氏慕尼黑创新中心）；Technische Universität München（慕尼黑工业大学）；SagivTech LTD.（SagivTech有限公司）
A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable distribution patterns. Drug development requires correlative analysis of various biomarkers in and between the tissue compartments. To enable that, tissue slides are manually annotated by expert pathologists. Manual annotation of tissue slides is a labor intensive, tedious and error-prone task. Automation of this annotation process can improve accuracy and cons…
Yildiz Technical University（耶尔德兹理工大学）；Istanbul Medipol University Hospital（伊斯坦布尔梅迪波尔大学医院）；Istanbul Technical University（伊斯坦布尔理工大学）
The cervical cancer developing from the precancerous lesions caused by the Human Papilloma Virus (HPV) has been one of the preventable cancers with the help of periodic screening. There are two types of grading conventions widely accepted among pathologists. On the other hand, inter-observer variability is an important issue for final diagnosis. In this paper, a whole-slide image grading benchmark for cervical cancer precursor lesions is introduced. The papillae of the cervical epithelium and overlapping cell problems are handled and a tissue classification method with a novel morphological fe…
University Hospital Essen (AöR)（埃森大学医院）；Cancer Research Center Cologne Essen (CCCE)（科隆-埃森癌症研究中心）；West German Cancer Center Essen（埃森西德癌症中心）；Karlsruhe Institute of Technology (KIT)（卡尔斯鲁厄理工学院）；University of Duisburg-Essen（杜伊斯堡-埃森大学）；Hannover Medical School（汉诺威医学院）
The segmentation of histopathological whole slide images into tumourous and non-tumourous types of tissue is a challenging task that requires the consideration of both local and global spatial contexts to classify tumourous regions precisely. The identification of subtypes of tumour tissue complicates the issue as the sharpness of separation decreases and the pathologist's reasoning is even more guided by spatial context. However, the identification of detailed types of tissue is crucial for providing personalized cancer therapies. Due to the high resolution of whole slide images, existing sem…
Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Given the large size of these images and the increase in the number of potential cancer cases, an automated solution as an aid to histopathologists is highly desirable. In the recent past, deep learning-based techniques have provided state of the art results in a wide variety of image analysis tasks, including analysis of digitized slides. However, the size of images and variability in histopathology tasks makes it a challenge to develop an integrated framework for histopathology image analysis. W…
Rutgers University（罗格斯大学）；Rutgers Cancer Institute of New Jersey（新泽西罗格斯癌症研究所）
Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances because of different tissue preparation and staining procedures, thus the predictable model learned from one domain may not be applicable to a new domain directly. Here we propose to adopt unsupervised domain adaptation to transfer the discriminative knowledge obtained from the source domain to the target domain without requiring labeling of images at the target…
Stony Brook University（石溪大学）；University of Brasília（巴西利亚大学）；Emory University（埃默里大学）
An accurate steatosis quantification with pathology tissue samples is of high clinical importance. However, such pathology measurement is manually made in most clinical practices, subject to severe reader variability due to large sampling bias and poor reproducibility. Although some computerized automated methods are developed to quantify the steatosis regions, they present limited analysis capacity for high resolution whole-slide microscopy images and accurate overlapped steatosis division. In this paper, we propose a method that extracts an individual whole tissue piece at high resolution wi…
Tissue Classification and Whole-Slide Images Analysis via Modeling of the Tumor Microenvironment and Biological Pathways
University of Regensburg（雷根斯堡大学）；Beijing Friendship Hospital, Capital Medical University（首都医科大学附属北京友谊医院）；Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg（弗里德里希-亚历山大-埃尔兰根-纽伦堡大学埃尔兰根大学医院）；Comprehensive Cancer Center Erlangen-EMN（埃尔兰根-EMN综合癌症中心）；Bavarian Cancer Research Center（巴伐利亚癌症研究中心）；Hanover Medical School（汉诺威医学院）；University Clinic Freiburg（弗莱堡大学医院）；Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学研究所MEVIS）
We present an algorithm for multi-scale tumor (chimeric cell) detection in high resolution slide scans. The broad range of tumor sizes in our dataset pose a challenge for current Convolutional Neural Networks (CNN) which often fail when image features are very small (8 pixels). Our approach modifies the effective receptive field at different layers in a CNN so that objects with a broad range of varying scales can be detected in a single forward pass. We define rules for computing adaptive prior anchor boxes which we show are solvable under the equal proportion interval principle. Two mechanism…
Queen Mary University of London（伦敦玛丽女王大学）；Karolinska University Hospital（卡罗林斯卡大学医院）
Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue components show low-contrast with varying tones of dark blue and pink, which makes difficult visual assessments, digital image analysis, and quantifications. These limitations can be overcome by IHC staining of target proteins of the tissue slide. IHC provides a selective, high-contrast imaging of cells and tissue components, but their use is largely limited by a …
Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently computationally impossible. The differentiation of cancer subtypes is based on cellular-level visual features observed on image patch scale. Therefore, we argue that in this situation, training a patch-level classifier on image patches will perform better than or similar to an image-level classifier. The challenge becomes how to intelligently combine patch-lev…
Radboud University Medical Center（拉德堡德大学医学中心）；Fraunhofer MEVIS（弗劳恩霍夫医学图像计算研究所）
Prostate cancer (PCa) is graded by pathologists by examining the architectural pattern of cancerous epithelial tissue on hematoxylin and eosin (H&E) stained slides. Given the importance of gland morphology, automatically differentiating between glandular epithelial tissue and other tissues is an important prerequisite for the development of automated methods for detecting PCa. We propose a new method, using deep learning, for automatically segmenting epithelial tissue in digitized prostatectomy slides. We employed immunohistochemistry (IHC) to render the ground truth less subjective and more p…
MiCo: Multiple Instance Learning with Context-Aware Clustering for Whole Slide Image Analysis
Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University（湖南生物信息省重点实验室，计算机科学与工程学院，中南大学）；Xinjiang Engineering Research Center of Big Data and Intelligent Software, School of Software, Xinjiang University（新疆大数据与智能软件工程研究中心，软件学院，新疆大学）
Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area. In this paper, we present context-aware stacked convolutional neural networks (CNN) for classification of breast WSIs into normal/benign, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). We first train a CNN using high pixel resolution patches to capture cellular level information. The feature responses generated by this model are then fed as input to a second CNN, stacked on top of the first. Training of this stac…
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）；Temple University（天普大学）
There has been a long pursuit for precise and reproducible glomerular quantification on renal pathology to leverage both research and practice. When digitizing the biopsy tissue samples using whole slide imaging (WSI), a set of serial sections from the same tissue can be acquired as a stack of images, similar to frames in a video. In radiology, the stack of images (e.g., computed tomography) are naturally used to provide 3D context for organs, tissues, and tumors. In pathology, it is appealing to do a similar 3D assessment. However, the 3D identification and association of large-scale glomerul…
The impact of tissue detection on diagnostic artificial intelligence algorithms in digital pathology
Karolinska Institutet（卡罗林斯卡学院）；Stavanger University Hospital（斯塔万格大学医院）；University of Stavanger（斯塔万格大学）；University of Bergen（卑尔根大学）；Synlab；Medical University of Lodz（罗兹医科大学）；University of Helsinki（赫尔辛基大学）；Mehiläinen Oy（梅希莱宁公司）；Mehiläinen Länsi-Pohja Hospital（梅希莱宁兰西波赫亚医院）；Aarhus University Hospital（奥胡斯大学医院）；Aarhus University（奥胡斯大学）；Griffith University（格里菲斯大学）；SciLifeLab（瑞典生命科学实验室）
Technische Hochschule Ingolstadt（英戈尔施塔特应用技术大学）；Klinikum Ingolstadt（英戈尔施塔特医院）；University of Regensburg（雷根斯堡大学）；University Hospital Regensburg（雷根斯堡大学医院）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）
Attention-based multiple instance learning (AMIL) algorithms have proven to be successful in utilizing gigapixel whole-slide images (WSIs) for a variety of different computational pathology tasks such as outcome prediction and cancer subtyping problems. We extended an AMIL approach to the task of survival prediction by utilizing the classical Cox partial likelihood as a loss function, converting the AMIL model into a nonlinear proportional hazards model. We applied the model to tissue microarray (TMA) slides of 330 lung cancer patients. The results show that AMIL approaches can handle very sma…
University of Warwick（华威大学）；Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学MEVIS研究所）；The Alan Turing Institute（艾伦·图灵研究所）；University Hospitals Coventry & Warwickshire（考文垂与沃里克郡大学医院）
Cross-slide image analysis provides additional information by analysing the expression of different biomarkers as compared to a single slide analysis. These biomarker stained slides are analysed side by side, revealing unknown relations between them. During the slide preparation, a tissue section may be placed at an arbitrary orientation as compared to other sections of the same tissue block. The problem is compounded by the fact that tissue contents are likely to change from one section to the next and there may be unique artefacts on some of the slides. This makes registration of each sectio…
Imaging Informatics Division（成像信息学部门）；Bioinformatics Institute（生物信息学研究所）；A*STAR（新加坡科技研究局）；Lucence Diagnostics（Lucence诊断公司）；Institute of Bioengineering and Nanotechnology（生物工程与纳米技术研究所）；Singapore General Hospital（新加坡综合医院）；National Cancer Centre Singapore（新加坡国家癌症中心）；Institute of Molecular and Cell Biology（分子与细胞生物学研究所）；National University of Singapore（新加坡国立大学）；Singapore Eye Research Institute（新加坡眼科研究所）；Image and Pervasive Access Lab（图像与普适访问实验室）
Motivation: High resolution 2D whole slide imaging provides rich information about the tissue structure. This information can be a lot richer if these 2D images can be stacked into a 3D tissue volume. A 3D analysis, however, requires accurate reconstruction of the tissue volume from the 2D image stack. This task is not trivial due to the distortions that each individual tissue slice experiences while cutting and mounting the tissue on the glass slide. Performing registration for the whole tissue slices may be adversely affected by the deformed tissue regions. Consequently, regional registratio…
ETH Zurich（苏黎世联邦理工学院）；Uppsala University（乌普萨拉大学）；IBM Research Europe（IBM欧洲研究院）；Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue patches. Such a formulation induces high computational requirements, and constrains the contextualization of the WSI-level representation to a single scale. A few MIL methods extend to multiple scales, but are computationally more demanding. In this paper, inspired by the pathological diagnostic process, we propose ZoomMIL, a method that learns to perform mu…
Sejong University（世宗大学）；University of Warwick（华威大学）；The University of Sheffield（谢菲尔德大学）；Stony Brook University（石溪大学）；National Cancer Institute, National Institutes of Health（美国国立卫生研究院国家癌症研究所）
High-resolution microscopy images of tissue specimens provide detailed information about the morphology of normal and diseased tissue. Image analysis of tissue morphology can help cancer researchers develop a better understanding of cancer biology. Segmentation of nuclei and classification of tissue images are two common tasks in tissue image analysis. Development of accurate and efficient algorithms for these tasks is a challenging problem because of the complexity of tissue morphology and tumor heterogeneity. In this paper we present two computer algorithms; one designed for segmentation of …
Australian National University（澳大利亚国立大学）；North South University（北南大学）
Spatial transcriptomics (ST) is essential for understanding diseases and developing novel treatments. It measures gene expression of each fine-grained area (i.e., different windows) in the tissue slide with low throughput. This paper proposes an Exemplar Guided Network (EGN) to accurately and efficiently predict gene expression directly from each window of a tissue slide image. We apply exemplar learning to dynamically boost gene expression prediction from nearest/similar exemplars of a given tissue slide image window. Our EGN framework composes of three main components: 1) an extractor to str…
Image Data Analytics, Informatics IT, Merck \& Co., Inc., West Point, PA 19486, USA Image Data Analytics, Informatics IT, Merck \& Co., Inc., Rahway, NJ 07065, USA
It is common for pathologists to annotate specific regions of the tissue, such as tumor, directly on the glass slide with markers. Although this practice was helpful prior to the advent of histology whole slide digitization, it often occludes important details which are increasingly relevant to immuno-oncology due to recent advancements in digital pathology imaging techniques. The current work uses a generative adversarial network with cycle loss to remove these annotations while still maintaining the underlying structure of the tissue by solving an image-to-image translation problem. We train…
Digital pathology enables remote access or consults and powerful image analysis algorithms. However, the slide digitization process can create artifacts such as out-of-focus (OOF). OOF is often only detected upon careful review, potentially causing rescanning and workflow delays. Although scan-time operator screening for whole-slide OOF is feasible, manual screening for OOF affecting only parts of a slide is impractical. We developed a convolutional neural network (ConvFocus) to exhaustively localize and quantify the severity of OOF regions on digitized slides. ConvFocus was developed using ou…
Geisel School of Medicine at Dartmouth（达特茅斯盖泽尔医学院）；Dartmouth College（达特茅斯学院）；Dartmouth-Hitchcock Medical Center（达特茅斯-希契科克医疗中心）
Deep learning-based methods, such as the sliding window approach for cropped-image classification and heuristic aggregation for whole-slide inference, for analyzing histological patterns in high-resolution microscopy images have shown promising results. These approaches, however, require a laborious annotation process and are fragmented. This diagnostic study collected deidentified high-resolution histological images (N = 379) for training a new model composed of a convolutional neural network and a grid-based attention network, trainable without region-of-interest annotations. Histological im…
From slides to AI-ready maps: Standardized multi-layer tissue maps as metadata for artificial intelligence in digital pathology
Medical University of Graz（格拉茨医科大学）；Graz University of Technology（格拉茨工业大学）；University of Maribor（马里博尔大学）；Masaryk University（马萨里克大学）；Masaryk Memorial Cancer Institute（马萨里克纪念癌症研究所）；University of Natural Resources and Life Sciences Vienna（维也纳自然资源与生命科学大学）；BBMRI-ERIC（欧洲生物样本库与生物分子资源研究基础设施联盟）；University Hospital RWTH Aachen（亚琛工业大学医院）；Charité - Universitätsmedizin Berlin（柏林夏里特医学院）；Freie Universität Berlin（柏林自由大学）；Humboldt-Universität zu Berlin（柏林洪堡大学）；EMPAIA International e.V.（EMPAIA国际协会）；European Society of Digital and Integrative Pathology（欧洲数字与整合病理学会）
Radboud University Medical Center（拉德堡德大学医学中心）；Canisius-Wilhelmina Hospital（卡尼修斯-威廉明娜医院）；Jeroen Bosch Hospital（耶伦博斯医院）
Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect mitotic figures in breast cancer tissue sections based on convolutional neural networks (CNNs). Application of CNNs to hematoxylin and eosin (H&E) stained histological tissue sections is hampered by: (1) noisy and expensive reference standards established by pathologists, (2) lack of generalization due to staining variation across laboratories, and (3) high compu…
WSI-INR: Implicit Neural Representations for Lesion Segmentation in Whole-Slide Images
Graduate School of Informatics, Nagoya University（名古屋大学信息科学研究生院）；Technical University of Munich (TUM)（慕尼黑技术大学）；TUM University Hospital（慕尼黑技术大学医院）；School of Computation and Information Technology（计算与信息科技学院）；Technical University of Munich（慕尼黑技术大学）；Information Technology Center, Nagoya University（名古屋大学信息技术中心）；Munich Center for Machine Learning（慕尼黑机器学习中心）；Department of Computing, Imperial College London（伦敦帝国理工学院计算系）；Research Center for Medical Bigdata（医学大数据研究中心）
A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools
Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China（北京清华长庚医院病理科，临床医学学院，清华大学医学院，清华大学，北京，中国）；Shenzhen International Graduate School, Tsinghua University, Shenzhen, China（深圳国际研究生院，清华大学，深圳，中国）
Deep learning methods are widely applied in digital pathology to address clinical challenges such as prognosis and diagnosis. As one of the most recent applications, deep models have also been used to extract molecular features from whole slide images. Although molecular tests carry rich information, they are often expensive, time-consuming, and require additional tissue to sample. In this paper, we propose tRNAsfomer, an attention-based topology that can learn both to predict the bulk RNA-seq from an image and represent the whole slide image of a glass slide simultaneously. The tRNAsfomer use…
Oxford NIHR Biomedical Research Centre (BRC)（牛津国家健康研究所生物医学研究中心）；John Radcliffe Hospital（约翰·拉德克利夫医院）
While challenging, the dense segmentation of histology images is a necessary first step to assess changes in tissue architecture and cellular morphology. Although specific convolutional neural network architectures have been applied with great success to the problem, few effectively incorporate visual context information from multiple scales. With this paper, we present a systematic comparison of different architectures to assess how including multi-scale information affects segmentation performance. A publicly available breast cancer and a locally collected prostate cancer datasets are being …
Rethinking Attention-Based Multiple Instance Learning for Whole-Slide Pathological Image Classification: An Instance Attribute Viewpoint
School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen（哈尔滨工业大学（深圳）计算机科学与技术学院）；Faculty of Computing, Harbin Institute of Technology（哈尔滨工业大学计算学部）；School of Science, Harbin Institute of Technology, Shenzhen（哈尔滨工业大学（深圳）理学院）
