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arXiv 2103.02156stat.ME
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脊惩罚自适应Mantel检验及其在影像遗传学中的应用

Ridge-penalized adaptive Mantel test and its application in imaging genetics

Dustin Pluta, Tong Shen, Gui Xue, Chuansheng Chen, Hernando Ombao, Zhaoxia Yu

摘要:

我们提出了一个脊惩罚自适应曼特尔测试(AdaMant)评估两个高维集的功能的关联。通过引入岭惩罚,AdaMant同时测试了多个指标之间的关联。我们展示了如何脊惩罚桥梁欧氏距离和马氏距离和相应的线性模型的角度关联测量和测试。这一结果不仅在理论上是有趣的,而且在惩罚性假设检验中也有重要的意义,特别是在高维环境中,如成像遗传学。将所提出的方法应用于健康成年人视觉工作记忆的成像遗传研究,我们确定了脑连接(通过EEG相干性测量)与选定遗传特征的有趣关联。

英文摘要:

We propose a ridge-penalized adaptive Mantel test (AdaMant) for evaluating the association of two high-dimensional sets of features. By introducing a ridge penalty, AdaMant tests the association across many metrics simultaneously. We demonstrate how ridge penalization bridges Euclidean and Mahalanobis distances and their corresponding linear models from the perspective of association measurement and testing. This result is not only theoretically interesting but also has important implications in penalized hypothesis testing, especially in high dimensional settings such as imaging genetics. Applying the proposed method to an imaging genetic study of visual working memory in health adults, we identified interesting associations of brain connectivity (measured by EEG coherence) with selected genetic features.

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