通过增材/先进制造设计损伤弹性人工骨和骨植入物的材料观点
A materials perspective on the design of damage-resilient artificial bones and bone implants through additive/advanced manufacturing
摘要：
经过五十多年的研究，骨植入物的失效仍然是我们老龄化人口中日益迫切需要解决的问题。在失败的原因中，灾难性脆性断裂是与植入物的材料和制造直接相关的事件之一，值得更多的关注。事实上，临床上可用的植入物在再现我们天然骨骼的分层和异质微观结构组织方面苍白无力，最终无法再现其机械强度和韧性。尽管如此，增材制造和先进制造的最新进展为仿生骨植入物的制造开辟了新的视野，同时对其表征，测试和建模提出了挑战。这篇重要的综述从材料的角度介绍了骨植入物研究的最新成果，旨在阐明这一多学科领域中一些最紧迫的问题。
英文摘要：
After more than five decades of research, the failure of bone implants is still an issue that becomes increasingly urgent to solve in our ageing population. Among the reasons for failure, catastrophic brittle fracture is one event that is directly related to the implant s material and fabrication and that deserves more attention. Indeed, clinically available implants pale at reproducing the hierarchical and heterogeneous microstructural organization of our natural bones, ultimately failing at reproducing their mechanical strength and toughness. Nevertheless, the recent advances in additive and advanced manufacturing open new horizons for the fabrication of biomimetic bone implants, challenging at the same time their characterization, testing and modelling. This critical review covers selected recent achievements in bone implant research from a materials standpoint and aims at deciphering some of the most urgent issues in this multidisciplinary field.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
