电纺纳米纤维在癌症研究中的应用：从体外3D癌症模型工程到治疗
Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy
摘要：
静电纺丝在历史上与组织工程相关，因为其能够产生具有与活组织的细胞外基质的机械和功能特性极其相似的机械和功能特性的纳米/微米级纤维材料。电纺纤维基质的普遍兴趣最近已扩展到癌症研究，既作为体外癌症建模的支架，又作为体内治疗递送的贴片。在这篇综述中，我们研究静电纺丝的过程中使用的大多数材料提供了一个简要的描述和概述，在这个过程中，讨论了改变工艺参数对纤维构象和组件的影响。然后，我们描述了两种不同的应用程序的静电纺丝服务的癌症研究：首先，作为三维（3D）的纤维材料，用于产生在体外临床前癌症模型;其次，作为补丁封装抗癌剂在体内传递。
英文摘要：
Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that are extremely similar to those of the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modelling and as patches for in vivo therapeutic delivery. In this review, we examine electrospinning by providing a brief description of the process and overview of most materials used in this process, discussing the effect of changing the process parameters on fiber conformations and assemblies. Then, we describe two different applications of electrospinning in service of cancer research: firstly, as three-dimensional (3D) fibrous materials for generating in vitro pre-clinical cancer models; and secondly, as patches encapsulating anticancer agents for in vivo delivery.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
