含甘氨酸、铁和锂的陨石蛋白质
Meteoritic Proteins with Glycine, Iron and Lithium
摘要：
我们报告了CV 3陨石Acfer 086、Allanum和KABA中存在主要由甘氨酸单元和铁组成的蛋白质骨架的聚合物酰胺[1]。这方面的证据来自于这些陨石在Folch提取后的颗粒，这些颗粒通过MALDI质谱法进行分析，以及在各种Folch溶剂相中形成的3D物理结构。我们观察到的两种物理形态是100微米尺度上的分支棒和捕获球。本文提出了两种可能的聚合物酰胺的分子结构。其中一种为2320 Da的血石素，含甘氨酸、羟基甘氨酸、铁、氧、锂等。另一种为甘氨酸、羟基甘氨酸、铁和氧的血红蛋白，分子量为1494 Da。血甘氨酸通过硅以三联体共价连接以形成三聚体。对每个分子碎片相关同位素的完整光谱的分析显示，2 H在地球上的增强非常高，平均为千分之25，700（sigma = 3，500，n=15），证实了这些分子来自地外，因此这些分子存在于CV 3陨石类的小行星母体中。血甘肽三聚体通过硅键连接成扩展的晶格，如在m/z 4641及以上的晶格碎片的质谱中所见[2]。鉴定血石素和血甘氨酸需要在室温下采用最少步骤进行质谱分析，以确保只有激光步骤才能使分子碎片化。通过永久封闭的Folch提取V形瓶以10倍放大率对3D结构进行成像。
英文摘要：
We report that polymer amide [1] with a protein backbone of mainly glycine units and iron is present in the CV3 meteorites Acfer 086, Allende and KABA. The evidence for this is from particles of these meteorites after Folch extraction being analyzed by MALDI mass spectrometry and from the 3D physical structures that form in the various Folch solvent phases. The two physical forms we observe are branching rods and entrapping spheres on the 100micron scale. Two potential molecular structures of polymer amide are presented in this report. One we term hemolithin of mass 2320Da, contains glycine, hydroxy-glycine, Fe, O and Li. The other, we term hemoglycin of mass 1494Da is of glycine, hydroxy-glycine, Fe and O. Hemoglycin is connected covalently in triplets by silicon to form a triskelion. Analysis of the complete spectrum of isotopes associated with each molecular fragment shows very high 2H enhancement above terrestrial averaging 25,700 parts per thousand (sigma = 3,500, n=15), confirming extra-terrestrial origin and hence the existence of these molecules within the asteroid parent body of the CV3 meteorite class. The hemoglycin triskelia join via silicon bonds into an extended lattice, as seen in mass spectrometry of lattice fragments at m/z 4641 and above [2]. The identification of hemolithin and hemoglycin required careful methodology at room temperature with the minimum of steps up to mass spectrometry analysis ensuring that only the laser step fragmented the molecules. The 3D structures were imaged through permanently closed Folch extraction V-vials at a magnification of 10.
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