Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, with around 50 million patients worldwide. Accessible and non-invasive methods of diagnosing and characterising AD are therefore urgently required. Electroencephalography (EEG) fulfils these criteria and is often used when studying AD. Several features derived from EEG were shown to predict AD with high accuracy, e.g. signal complexity and synchronisation. However, the dynamics of how the brain transitions between stable states have not been properly studied in the case of AD and EEG data. Energy landscape analysis is a method that can be used to quantify these dynamics. This work presents the first application of this method to both AD and EEG. Energy landscape assigns energy value to each possible state, i.e. pattern of activations across brain regions. The energy is inversely proportional to the probability of occurrence. By studying the features of energy landscapes of 20 AD patients and 20 healthy age-matched counterparts, significant differences were found. The dynamics of AD patients' brain networks were shown to be more constrained - with more local minima, less variation in basin size, and smaller basins. We show that energy landscapes can predict AD with high accuracy, performing significantly better than baseline models.
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Ferrara（费拉拉大学）
Transcranial Magnetic Stimulation (TMS) combined with EEG recordings (TMS-EEG) has shown great potential in the study of the brain and in particular of Alzheimer's Disease (AD). In this study, we propose an automatic method of determining the duration of TMS induced perturbation of the EEG signal as a potential metric reflecting the brain's functional alterations. A preliminary study is conducted in patients with Alzheimer's disease (AD). Three metrics for characterizing the strength and duration of TMS evoked EEG (TEP) activity are proposed and their potential in identifying AD patients from …
The diagnosis of Alzheimer's disease (AD) in routine clinical practice is most commonly based on subjective clinical interpretations. Quantitative electroencephalography (QEEG) measures have been shown to reflect neurodegenerative processes in AD and might qualify as affordable and thereby widely available markers to facilitate the objectivization of AD assessment. Here, we present a novel framework combining Riemannian tangent space mapping and elastic net regression for the development of brain atrophy markers. While most AD QEEG studies are based on small sample sizes and psychological test…
Alzheimers disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the early stages would be useful for early diagnosis of AD, but this would involve dealing with large numbers of people because up to 50% of dementia sufferers do not receive a formal diagnosis. Thus, there is a need for accurate, low-cost, and easy-to-use biomarkers that could be used to detect AD in its early stages. Potentially, electroencephalogram (EEG) based …
Leveraging a Foundation Model for the EEG-Based Diagnosis of Alzheimer's Disease
University of California, San Diego（加利福尼亚大学圣地亚哥分校）；HippoScreen Neurotech Corp.（HippoScreen神经科技公司）；Swartz Center for Computational Neuroscience（Swartz计算神经科学中心）
Emerging evidence shows that cognitive deficits in Alzheimer disease (AD) are associated with disruptions in brain functional connectivity. Thus, the identification of alterations in AD functional networks has become a topic of increasing interest. However, to what extent AD induces disruption of the balance of local and global information processing in the human brain remains elusive. The main objective of this study is to explore the dynamic topological changes of AD networks in terms of brain network segregation and integration. We used electroencephalography (EEG) data recorded from 20 par…
Medical University of Vienna（维也纳医科大学）；University of Oxford（牛津大学）；Medical University of Innsbruck（因斯布鲁克医科大学）；Kepler University Hospital（开普勒大学医院）
As societies around the world are ageing, the number of Alzheimer's disease (AD) patients is rapidly increasing. To date, no low-cost, non-invasive biomarkers have been established to advance the objectivization of AD diagnosis and progression assessment. Here, we utilize Bayesian neural networks to develop a multivariate predictor for AD severity using a wide range of quantitative EEG (QEEG) markers. The Bayesian treatment of neural networks both automatically controls model complexity and provides a predictive distribution over the target function, giving uncertainty bounds for our regressio…
A Synchronous EEG-fNIRS BCI: A Proof-of-Concept for Multimodal Avalanche Analysis of Motor Cognition in Older Adults
Shanghai Jiao Tong University（上海交通大学）；CenBRAIN Neurotech, School of Engineering, Westlake University（西湖大学工学院 CenBRAIN 神经技术）；Department of Neurology, Affiliated Hangzhou First People’s Hospital, Westlake University, School of Medicine（西湖大学医学院附属杭州市第一人民医院神经内科）
Alzheimer's disease (AD) is a neurodegenerative disease known to affect brain functional connectivity (FC). Linear FC measures have been applied to study the differences in AD by splitting neurophysiological signals such as electroencephalography (EEG) recordings into discrete frequency bands and analysing them in isolation. We address this limitation by quantifying cross-frequency FC in addition to the traditional within-band approach. Cross-bispectrum, a higher-order spectral analysis, is used to measure the nonlinear FC and is compared with the cross-spectrum, which only measures the linear…
Sleep change is commonly reported in Alzheimer's disease (AD) patients and their brain wave studies show decrease in dreaming and non-dreaming stages. Although sleep disturbance is generally considered as a consequence of AD, it might also be a risk factor of AD as new biological evidence shows. Leveraging National Sleep Research Resource (NSRR), we built a unique cohort of 83 cases and 331 controls with clinical variables and EEG signals. Supervised tensor factorization method was applied for this temporal dataset to extract discriminative sleep patterns. Among the 30 patterns extracted, we i…
Kingston University（金斯顿大学）；Digital Information Research Centre（数字信息研究中心）；Faculty of Science, Engineering and Computing（科学、工程与计算学院）
Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function. High rate of deaths and high cost for detection, treatments and patient's care count amongst its consequences. Early detection of AD is considered of high importance for improving the quality of life of patients and their families. The aim of this thesis is to introduce novel non-invasive early diagnosis methods in order to speed the diagnosis, reduce the assoc…
Brain-MGF: Multimodal Graph Fusion Network for EEG-fMRI Brain Connectivity Analysis Under Psilocybin
School of Information Technology, Monash University Malaysia（信息技术学院，墨尔本大学马来西亚分校）；Department of Data Science and AI, Faculty of Information Technology, Monash University（数据科学与人工智能系，信息科技学院，墨尔本大学）；Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University（脑与心理健康研究所，心理学科学学院，墨尔本大学）
Complexity and Stability of Neural Activity Across Aging and Neurodegenerative Disease
Southern University of Science and Technology（南方科技大学）；Shenzhen People’s Hospital, The Second Affiliated Hospital of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology（深圳市人民医院，暨南大学附属第二医院，南方科技大学附属第一医院）；Tianjin Huanhu Hospital（天津市环湖医院）；Shenzhen Bay Laboratory（深圳湾实验室）
