超声调控微泡外泌体治疗COVID-19肺损伤
Ultrasound-based Control of Micro-Bubbles for Exosome Delivery in Treating COVID-19 Lung Damage
摘要：
最近的COVID-19大流行导致高死亡率，尤其是患有潜在健康问题的患者。患有急性COVID-19感染的患者表现出的更严重的症状之一是呼吸困难和呼吸短促，这主要是由于过多的液体（细胞渗漏和细胞因子风暴）和粘液碎片填充了肺泡，并降低了表面活性剂张力，导致肺部沉重和僵硬。在这篇论文中，我们提出了使用充满外泌体的微泡，这些外泌体可以在暴露于超声信号时释放，作为可能的补救疗法，用于治疗病情恶化的COVID-19患者。最近的研究表明，外泌体可用于修复和治疗患有病毒感染的患者的肺损伤。我们已经进行了模拟，以显示超声信号的功效，该超声信号将穿透组织层到达包含微泡的肺泡。我们的研究结果表明，具有低频率的超声信号需要振荡和破裂的聚合物基微泡。我们提出的系统可用于需要立即抢救治疗肺损伤的患者，以及可能患有病毒复发感染的康复患者，其中微泡将在临时治疗窗口内保持休眠状态，直到它们暴露于超声信号。
英文摘要：
The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and cytokine storm) and mucoid debris that have filled lung alveoli, and reduced the surfactant tension resulting in heavy and stiff lungs. In this paper, we propose the use of micro-bubbles filled with exosomes that can be released upon exposure to ultrasound signals as possible rescue therapy in deteriorating COVID-19 patients. Recent studies have shown that exosomes can be used to repair and treat lung damage for patients who have suffered from viral infection. We have conducted simulations to show the efficacy of the ultrasound signals that will penetrate through layers of tissues reaching the alveoli that contain the micro-bubbles. Our results have shown that ultrasound signals with low frequencies are required to oscillate and rupture the polymer-based micro-bubbles. Our proposed system can be used for patients who require immediate rescue treatments for lung damage, as well as for recovered patients who may suffer from viral relapse infection, where the micro-bubbles will remain dormant for a temporary therapeutic window until they are exposed to the ultrasound signals.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
