Corti器官的一套灵活的解剖学力学模型
A flexible anatomical set of mechanical models for the organ of Corti
摘要：
我们建立了一个灵活的平台来研究Corti器官（OoC）在基底膜（BM）振动到内毛细胞束（IHB）振动的转换中的机械操作。我们考虑的解剖成分是外毛细胞（OHC），外毛细胞束，Deiters细胞，Hensen细胞，IHB和网状板的各个部分。在每一个组成部分，我们应用牛顿的运动方程。所述组分彼此耦合并且进一步耦合到所述盖下间隙中的内淋巴流体运动。这使我们能够获得作用在IHB上的力，从而研究其运动作为不同部件的参数的函数。一些部件包括非线性机械响应。我们发现，轻微弯曲的OHC的顶端可以有一个显着的影响，从BM到IHB的运动通道，包括关键的振荡器行为。特别是，我们的模型意味着，组件的OoC可以合作，以提高频率选择性，幅度压缩和信噪比的通道从BM到IHB。由于模型是模块化的，因此很容易修改每个组件的假设和参数。
英文摘要：
We built a flexible platform to study the mechanical operation of the organ of Corti (OoC) in the transduction of basilar membrane (BM) vibrations to oscillations of an inner hair cell bundle (IHB). The anatomical components that we consider are the outer hair cells (OHCs), the outer hair cell bundles, Deiters cells, Hensen cells, the IHB and various sections of the reticular lamina. In each of the components we apply Newton's equations of motion. The components are coupled to each other and are further coupled to the endolymph fluid motion in the subtectorial gap. This allows us to obtain the forces acting on the IHB, and thus study its motion as a function of the parameters of the different components. Some of the components include a nonlinear mechanical response. We found that slight bending of the apical ends of the OHCs can have a significant impact on the passage of motion from the BM to the IHB, including critical oscillator behaviour. In particular, our model implies that the components of the OoC could cooperate to enhance frequency selectivity, amplitude compression and signal to noise ratio in the passage from the BM to the IHB. Since the model is modular, it is easy to modify the assumptions and parameters for each component.
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