紧凑型核-壳3D手性超材料的毫微微摩尔生物检测
Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial
摘要：
用于实时识别特定生物标志物的高灵敏度和选择性的无标记装置预计将显著影响生物传感领域。等离子体激元系统将光限制在纳米体积内并通过调整纳米结构的尺寸、形状和材料特征来操纵光的能力，使得这些系统成为生物医学设备的有希望的候选者。在这项工作中，我们展示了一个紧凑的三维金属介电核壳手性超材料阵列的工程传感能力。纳米螺旋的固有手性使系统具有圆偏振依赖性，不受背景干扰的影响，即使在复杂的环境中也能工作。核壳结构增强了手性超材料在远场和近场的传感特性，也为分子固定提供了大的表面。使用我们的系统，我们记录了约800 nm/RIU的灵敏度和FOM= 1276 RIU-1。通过检测TAR DNA结合蛋白43（TDP-43）（一种用于筛选神经退行性疾病的关键生物标志物），证明了该系统的传感能力。特别是，该传感器在不同的环境中进行了测试，例如人类血清，浓度范围从1 pM到10 fM，为新型诊断工具开辟了新的前景。
英文摘要：
Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and to manipulate it by tuning the size, shape and material features of the nanostructures, makes these systems promising candidates for biomedical devices. In this work we demonstrate the engineered sensing capabilities of a compact array of 3D metal dielectric core-shell chiral metamaterial. The intrinsic chirality of the nano-helices makes the system circular polarization dependent and unaffected by the background interferences, allowing to work even in complex environment. The core-shell architecture enhances the sensing properties of the chiral metamaterial on both in the far and near field, offering also a large surface to molecular immobilization. With our system we recorded sensitivity of about 800nm/RIU and FOM= 1276 RIU-1. The sensing abilities of the system is demonstrated with the detection of the of the TAR DNA-binding protein 43 (TDP-43) , a critical biomarker for the screening of neurodegenerative diseases. In particular, the sensor was tested in different environments, such as human serum, with concentrations ranging from 1pM down to 10fM, opening new perspectives for novel diagnostic tools.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
