Au（111）表面Mo诱导缺陷成核的鸟嘌呤四重网络与石墨烯纳米带的室温自组装
Room temperature self-assembly of cation-free guanine quartet network nucleated from Mo-induced defect on decorated Au(111) with graphene nanoribbons
摘要：
鸟嘌呤四链体是由多个鸟嘌呤四联体（GQs）堆叠而成的一类重要的新型分子靶点，其应用范围从纳米电子器件到抗癌药物。金属阳离子引入GQ结构中形成稳定的G-四链体，而其他通道尚未报道。本文报道了Au（111）表面上广泛的无金属GQ网络的室温分子自组装。在Au（111）表面注入钼原子所引起的表面缺陷被用来成核和稳定无阳离子的GQ网络。此外，用7-扶手椅型石墨烯纳米带（7-AGNR）修饰的Au（111）表面通过在空间上和化学上固化从Au台阶边缘成核的无序相而导致更广泛的GQ网络。扫描隧道显微镜/光谱（STM/STS）和密度泛函理论（DFT）计算证实了GQ网络的形成，并解开了成核和生长机制。这种方法刺激无阳离子的G-四重网络的形成在RT和可以导致稳定的新出现的分子自组装。
英文摘要：
Guanine-quadruplex, consisting of several stacked guanine-quartets (GQs), has emerged as an important category of novel molecular targets with applications from nanoelectronic devices to anticancer drugs. Incorporation of metal cations into GQ structure is utilized to form stable G-quadruplexes, while no other passage has been reported yet. Here we report the room temperature (RT) molecular self-assembly of extensive metal-free GQ networks on Au(111) surface. Surface defect induced by an implanted molybdenum atom within Au(111) surface is used to nucleate and stabilize the cation-free GQ network. Additionally, the decorated Au(111) surface with 7-armchair graphene nanoribbons (7-AGNRs) results in more extensive GQ networks by curing the disordered phase nucleated from Au step edges spatially and chemically. Scanning tunneling microscopy/spectroscopy (STM/STS) and density functional theory (DFT) calculations confirm GQ networks' formation and unravel the nucleation and growth mechanism. This method stimulates cation-free G-quartet network formation at RT and can lead to stabilizing new emerging molecular self-assembly.
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