不同栓塞材料对伽玛刀治疗脑动静脉畸形剂量分布影响的统计分析
A Statistical Analysis of the Effect of Different Embolization Materials on Gamma Knife Arteriovenous Malformation Dose Distributions
摘要：
伽玛刀放射外科（GKRS）是血管内介入术后新诊断AVM和残留AVM的治疗选择。本研究的目的是确定市售液体栓塞剂是否会因60 Co射束的衰减而降低靶点的辐射剂量。分析了三种不同栓塞材料（即Onyx、氰基丙烯酸酯和聚乙烯醇（PVA））的累积剂量。在Geant 4仿真工具包中实现的蒙特卡罗模拟中采用了8 mm尺寸的准直器头盔。对获得的剂量累积进行了评价，结果表明计算的剂量测定存在统计学显著差异。
英文摘要：
Gamma Knife Radiosurgery (GKRS) is a treatment choice in newly diagnosed AVMs and residual AVMs following endovascular interventions. Aim of this study is to determine if commercially available liquid embolic agents reduce the radiation dose to the target due to the attenuation of the 60Co beam. Doses accumulated by three different embolization materials, namely: Onyx, cyanoacrylate and polyvinyl alcohol (PVA) were analysed. A collimator helmet size of 8mm was employed in a Monte-Carlo simulation implemented in Geant4 simulation toolkit. Obtained dose accumulations were evaluated and results demonstrated statistically significant differences in the dosimetries calculated.
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