纳米开关的定量模型准确预测热致动行为
A quantitative model for a nanoscale switch accurately predicts thermal actuation behavior
摘要：
温度的操纵可用于致动含有金纳米颗粒的DNA折纸纳米铰链。我们开发了一个物理模型，该系统使用配分函数分析的纳米铰链和纳米粒子之间的相互作用，以预测的概率，纳米铰链是在给定的温度下打开。该模型与实验数据吻合良好，并预测实验条件，允许的纳米铰链的致动温度被调谐在从$30$ ${}^{\circ}\mathrm{C}$到$45$ ${}^{\circ}\mathrm{C}$的温度范围内。此外，该模型揭示了系统上令人惊讶的物理约束。这种物理洞察力和预测潜力的结合可能会为未来将纳米颗粒整合到动态DNA折纸结构中的设计提供信息。此外，我们的建模方法可以扩展到考虑整合到核酸装置中的其他类型的功能元件或致动机制的掺入、稳定性和致动。
英文摘要：
Manipulation of temperature can be used to actuate DNA origami nano-hinges containing gold nanoparticles. We develop a physical model of this system that uses partition function analysis of the interaction between the nano-hinge and nanoparticle to predict the probability that the nano-hinge is open at a given temperature. The model agrees well with experimental data and predicts experimental conditions that allow the actuation temperature of the nano-hinge to be tuned over a range of temperatures from $30$${}^{\circ}\mathrm{C}$ to $45$${}^{\circ}\mathrm{C}$. Additionally, the model reveals surprising physical constraints on the system. This combination of physical insight and predictive potential is likely to inform future designs that integrate nanoparticles into dynamic DNA origami structures. Furthermore, our modeling approach could be expanded to consider the incorporation, stability, and actuation of other types of functional elements or actuation mechanisms integrated into nucleic acid devices.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
