流动乳状液中液滴极化的触发因素--粘附
Adhesion as a trigger of droplet polarization in flowing emulsions
摘要：
在形态发生过程中，组织受到大的外力作用，并发生整体变形。我们使用合成的类似物的组织，研究细胞间粘附的影响，在这种压力下的响应粘性细胞组件。特别地，我们使用仿生乳液，其中液滴被官能化以表现出特定的液滴-液滴粘附。我们流动这些乳液在微流控收缩，并通过共聚焦显微镜研究他们对这种强制变形的反应。我们发现，雪崩的大小分布之间的排斥和粘附液滴是保守的。然而，粘附局部地削弱了液滴-液滴接触的破裂，这又拉动重新排列的液滴。结果，粘合剂液滴沿着收缩部中的伸长轴变形得更多。这一发现可能有助于阐明形态发生过程中极化过程的起源。
英文摘要：
Tissues are subjected to large external forces and undergo global deformations during morphogenesis. We use synthetic analogues of tissues to study the impact of cell-cell adhesion on the response of cohesive cellular assemblies under such stresses. In particular, we use biomimetic emulsions in which the droplets are functionalized in order to exhibit specific droplet-droplet adhesion. We flow these emulsions in microfluidic constrictions and study their response to this forced deformation via confocal microscopy. We find that the distributions of avalanche sizes are conserved between repulsive and adhesive droplets. However, adhesion locally impairs the rupture of droplet-droplet contacts, which in turn pulls on the rearranging droplets. As a result, adhesive droplets are a lot more deformed along the axis of elongation in the constriction. This finding could shed light on the origin of polarization processes during morphogenesis.
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